9 genomes BUD0645 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG2656 rrnAC2415 HVO_0355 Hbo1125 Hmu0154 Hut0528 hla0142 NP0128A HQ3389A

Pairwise sequence scores
Consensus score	1901	VNG2656	Hut0528	rrnAC2415	Hmu0154	NP0128A	HQ3389A	HVO_0355	hla0142	Hbo1125
1362	VNG2656	1967	1093	1189	1123	1225	1107	1180	1138	1147
1220	Hut0528	1093	1895	1244	1217	1061	1024	1033	974	1065
1396	rrnAC2415	1189	1244	2046	1387	1261	1145	1173	1118	1165
1398	Hmu0154	1123	1217	1387	1916	1229	1098	1192	1116	1181
1435	NP0128A	1225	1061	1261	1229	1896	1203	1237	1161	1305
1439	HQ3389A	1107	1024	1145	1098	1203	2202	1291	1188	1356
1489	HVO_0355	1180	1033	1173	1192	1237	1291	1902	1273	1350
1405	hla0142	1138	974	1118	1116	1161	1188	1273	1846	1276
1538	Hbo1125	1147	1065	1165	1181	1305	1356	1350	1276	1948

308 symbols
consensus       MDLRVRGGAPAAPFLSAADLFETEYDLDRPVTVRVREDPDERTWAGHYDDRHVLNISRQA
#oth            .12215.43.22..11.1121411331461.5.41222..1..212.2325.4.21.23.
VNG2656         :EI::S:AG:::::F::R:V::PSH:::L::D:HI:SN::::::::::::H::::::Q::
Hut0528         :::QFD:TG:T::::G:R:::R::H:::::::::ITSE:::::RVS:DA:G:Q:T:::H:
rrnAC2415       ::VH:Q::-::E:::G:R:::S::H::K:::::::::::::::RVS:S::A:R:T:::::
Hmu0154         ::VH::::-::::::::::::A:::EI:GD:::::C:::::::RVS:DEES:C:T:::::
NP0128A         ::I::::DG::::::::R:MLD:::G:E:::V:DI:D::::::MV:::::::E:VV::R:
HQ3389A         ::V::::A:::E:::G::E::::::::NS::Y:D:::N:::::::A::E::::::::QK:
HVO_0355        :::::V:::::D::::::::::::FE:SY::F::::D:::S:::::::Q:H:::::::::
hla0142         :::::Q:DV:PD:::G::::::::WS::D::H:K:::::::::::::::GY::::V:KR:
Hbo1125         :::::L:S::TD::::::::::::::::K::H:T::D::::::::A::::::E:::::::

consensus       ATSAMARELALHELAHMARYEEGHPSHTQSTEEALYLALAGRSVERRKLAHCYQIANHMK
#oth            ...111..121..21..213.32.2..61112.121.1.2.321.112221.......31
VNG2656         :::V:::::::::F:::H:H:R::::::L:MD:V:F:::T::E::Q:V:T::::::::V:
Hut0528         ::::L:::II:::F:::HHA:R:::::SL::::V:F:::S:::::::TVTQ:::::::AR
rrnAC2415       :::::::::::::Y:::HHH:C:::::::::R::I::::::::::Q:::T::::::::::
Hmu0154         :::::::::::::F:::H::::A::::::::R::I::::::Q:::::T:S::::::::::
NP0128A         :::::::::::::F:::::::QA::::L:::::::F:::::::::Q:::S::::::::::
HQ3389A         :::::::::VV::::::::N::::V::HLA:::::::::::E:I::H:I:::::::::::
HVO_0355        ::::::::::::::S::::N::::V::Y:::R::VF::::::T:::::::::::::::C:
hla0142         ::::::::::V:::S:::::::::A::V:::::::::G:S:ET:::::::::::::::::
Hbo1125         :::::G:::V:::::::V::::Q:A::I:::::::::::S:K::::::::::::::::::

consensus       DIYADDITLSVAPADKLVDFLESELAAAV--ADRPADSPRPG---------------RRV
#oth            .1....212323233..36...141.1.211.2515524644111111111111112421
VNG2656         :::::::::::G:T:::RS:::::::::I::::Q:::RQQA::::::::::::::::H:L
Hut0528         ::::::VWID::::A:::::::AGV:::::::::QP::VTWE:::::::::::::::-::
rrnAC2415       :V:::::WMP:V:G::::P:::AS:::::::::::G:P:TWDRSTSSTRVRQPSEPAA:L
Hmu0154         ::::::VW:D:V::::::A::::S:::::::::T:R:RGAWD:::::::::::::::-:L
NP0128A         :::::::::DIG:T::::S::::S::R:L::::S:PSP:ED::::::::::::::::::L
HQ3389A         :::::::::A:TAPT::I::::::::R::AS:SA::L::::N::::::::::::::S:::
HVO_0355        ::::::L:::::::::::Q::::Q::::L::::::QA:G:::::::::::::::::S:L:
hla0142         :::::::::::::::::LG::::T:::::::::::EV:RDGA:::::::::::::::PP:
Hbo1125         ::::::::::LGL:E:::H:::::::R:I:::AN:GP::W:N::::::::::::::S:L:

consensus       TAGADPEITAVNAAFALALVERHDLIGPDHRLYDLAHAAADDAPSVDLDAFKRRFRSLSD
#oth            2242..2111...1.....2...122451.11....3..25.12513343.221.22.33
VNG2656         ::::::SM:::::::::::L::::A:PG:::::::::::GQ:::EI:V:G:R:::AT:GP
Hut0528         S:TS::D::::::::::::::::G:V:D::::::::Y::ET:::HIGF:E:RE::::::R
rrnAC2415       :PA:::D::::::::::::C:::::VET::::::::::::Q::E::::TE:::H:AA::P
Hmu0154         :PAT::D:N::::::::::::::::V::::PI::::::::E:::H:SFEG::::::T:AR
NP0128A         RP:::::::V:::::::::L::::A:DA::::::::S:::A:::::S:S:::::::::E:
HQ3389A         :VD:::::::::::::::::::::::SA::::::::::::::::TI:MK::TQH::::EA
HVO_0355        :::S:::::::::G:::::::::::VES:::::::::::G::::::S:ET::EH::T:A:
hla0142         ::::::::::::::::::::::::IA::N::I::::R::GS:TDA::V::::E::LA:GP
Hbo1125         ::N::::::::::::::::::::G::D::::I::::::::::::D:E:S:::E:::::::

consensus       DPDESEYRKALVDVTRAYAVGT-----PRAAD----------------------------
#oth            2122.22.33..13313.155733332663111111111111111111111111111111
VNG2656         :::::DC:RG:::TI:T::DAQTTTTG:-:::::::::::::::::::::::::::::::
Hut0528         ::T:::F:AE:::LV:T::SR::::::T:V::::::::::::::::::::::::::::::
rrnAC2415       E:::::F::::::::::::G:G:::::S::::::::::::::::::::::::::::::::
Hmu0154         :T::::::::::::::::::ASNG:::DS:::::::::::::::::::::::::::::::
NP0128A         :::::A:::::::A::E:VLSDT::::GQ:::::::::::::::::::::::::::::::
HQ3389A         N:TT::::SE:::A:::::L:ESGLAQSET::EEQKCGQRIDSNKTLTPQSQSQSRSQSQ
HVO_0355        ::SK::::RT::::VKR:V:NP:::::RM:::::::::::::::::::::::::::::::
hla0142         ::S::D::::::AAA:::::--:::::-----::::::::::::::::::::::::::::
Hbo1125         ::T::D::::::::::E::I::NDRGG:A:::::::::::::::::::::::::::::::

consensus       --------
#oth            11111111
VNG2656         ::::::::
Hut0528         ::::::::
rrnAC2415       ::::::::
Hmu0154         ::::::::
NP0128A         ::::::::
HQ3389A         FQFGPASD
HVO_0355        ::::::::
hla0142         ::::::::
Hbo1125         ::::::::