[K] (-) COG1709 Predicted transcriptional regulator 9 genomes BUD0663 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1616 rrnAC1742 HVO_2421 Hbo2122 Hmu2120 Hut0423 hla1280 NP4796A HQ2869A

Pairwise sequence scores
Consensus score	1754	Hut0423	VNG1616	NP4796A	rrnAC1742	Hmu2120	hla1280	HQ2869A	HVO_2421	Hbo2122
1219	Hut0423	1737	1050	1115	1188	1159	1165	1099	1122	1115
1315	VNG1616	1050	2007	1177	1165	1160	1178	1210	1249	1232
1341	NP4796A	1115	1177	1740	1200	1219	1227	1186	1265	1217
1395	rrnAC1742	1188	1165	1200	1746	1389	1278	1198	1247	1252
1381	Hmu2120	1159	1160	1219	1389	1747	1250	1172	1268	1240
1450	hla1280	1165	1178	1227	1278	1250	1733	1376	1373	1391
1459	HQ2869A	1099	1210	1186	1198	1172	1376	1744	1512	1486
1558	HVO_2421	1122	1249	1265	1247	1268	1373	1512	1769	1538
1542	Hbo2122	1115	1232	1217	1252	1240	1391	1486	1538	1736

269 symbols
consensus       ----------------------------------MTAAPRDELARRIAGEITLSDDPGAT
#oth            111111111111111111111111111111122335552.23.13111..111.121.1.
Hut0423         :::::::::::::::::::::::::::::::::MDRGSD::R::N::::::AT::R::E:
VNG1616         MPAPSSRRGLAVAVRAGVVLDGFFPGVSQTEGMDTDDD::EG::V::S::V:::::::::
NP4796A         ::::::::::::::::::::::::::::::::::-MRE::A:::E:::::V:::::::::
rrnAC1742       :::::::::::::::::::::::::::::::::::AGGA::D::EKM:::VA::::::::
Hmu2120         :::::::::::::::::::::::::::::::::::VRG::A:::EKM::::A:::A::E:
hla1280         ::::::::::::::::::::::::::::::::::-MSDA:E::S::::::::::::::::
HQ2869A         :::::::::::::::::::::::::::::::::MT::::::D::::::::V:::N:::::
HVO_2421        :::::::::::::::::::::::::::::::VFA:::::::D::::::::::::::::::
Hbo2122         ::::::::::::::::::::::::::::::::::::EV::::::::::::::::::A:::

consensus       LRKWRTDFDVSQTALADQLDVSSSVVSDYESGRRESPGIGVVRRMVEALLDIDERRGGDR
#oth            21...11.111.13..22....2..1........21...2213.3.51..21.12...51
Hut0423         IS::::::EIA:SE::AE::::P:::::::::::DN:::A::D:T:T:::A::Q::::RH
VNG1616         :::::::::::::::::E:::::::I:::::::::::::AL:S:L:N:::::::::::TH
NP4796A         :::::EE:::A::T:::E::::A:::::::::::GN:::QI:Q:V::G::TV::::::::
rrnAC1742       ::::::::::A::E:::E::::P:::::::::::DN::::::::L:V:::::::N::::H
Hmu2120         V:::::::E::::G:::A::::P:::::::::::DN::::::Q:V:S:::::::::::EH
hla1280         :::::::::::::E::::::::::::::::::::::::::::::T:DG::::::::::G:
HQ2869A         :::::::::I:::T:::::::::::I::::::::::::::::::::::::::::A:::G:
HVO_2421        :::::::::I::::::E::::::::::::::::::::::::I::::::::::::A:::S:
Hbo2122         :::::::::I::::::E::::::::I:::::::::::::::::::::::::::QA:::S:

consensus       IRQHARVLSAGFDSDIVQDLREYPAAVPLERFYDAIDATELVRGDQDTVSGHTVINSIEA
#oth            21.2...1....1111.4..1.111322245321.22.12234.331213...1.1.13.
Hut0423         :::::::I:::::NT::S::::FS::::ID:YFE::E::K:AD:SRE::V:::::D::::
VNG1616         :G:F:::::::::::V:L:::::::::E:DAL:::V::::V:P::R:::::::::D::K:
NP4796A         V::::::::::::::V:Y:::::::T::IP::HE::G:EPVTE:QAE::A:::::::V::
rrnAC1742       :::::::::::::::V:H:::::S:N:GV::V::::::E::F::S::::A::::::::A:
Hmu2120         :::::::::::::::V:H::G::::NL::AD:::::::::::G::A:::A::::::::A:
hla1280         L::Y::::::::E::::H:::::ST:::::E::E:MG:::I:::E::H:N::::::::::
HQ2869A         :::Y:::I::::E:::::::::::T:I:::TL:E:MG:::I::::H:RI::::I::::::
HVO_2421        :::Y::::::::E:::::::::::TSI::NS:::::G::PI:D::::RI:::::::::Q:
Hbo2122         :::Y:::I::::E::::::::::STSI::::L:::M:::::::::H:H::::::::::Q:

consensus       ITRLSSEEFYRLYGQSTNRALVFTNVTRGESPLVAMRVVTPTPNAVVLHGLEDDDLWEHA
#oth            .2...111..1.....11.1.2..211........1...3...1..2...235321.11.
Hut0423         ::::::::::::::::S::::::::::::::::::::::N::::::::::I:SE:V::R:
VNG1616         :Q:::GDG:::::::::S:V:G::::S::::::::::::D:::S::L::::SP:::::::
NP4796A         :K::::::::::::::::::::::D::::::::::L:::::::S::I::::DA:::::::
rrnAC1742       ::::::D:::Q::::::::::::::::::::::::L:::S::::::I::::::EAV::::
Hmu2120         ::::::D:::Q:::::::::::::D::::::::::L::::::::::::::::S:A::D::
hla1280         :::::::::::::::::::::::::::::::::::L:::S::::::::::I::G:::D::
HQ2869A         :::::::::::::::::S::::::GI:::::::::::::N::::::::::VTEAE:::::
HVO_2421        :::::::::::::::::S::::::G::::::::::::::::::::::::::SK:::::::
Hbo2122         :::::::::::::::::S:::I::D:S:::::::::::::::::::I::::TE:::::::

consensus       PALARIDGFSLAITDRDLDAMLADLRELP
#oth            32..33.111..42352213213412535
Hut0423         AD:::V:::A::A:TL::::::DR:A:QF
VNG1616         ::::KR::::::V:EMPVED:::S::QHA
NP4796A         :::::A::V:::T:TMP:E:L:EE::SF:
rrnAC1742       QD:::::D:::::::IE:EDL:GG:::::
Hmu2120         VD::::::::::VA:AEM:E:::G::::R
hla1280         AD:::V:::::::ST::::DC::::QA:-
HQ2869A         ::::T:::::::LSNQ::ET:ID:V:R:V
HVO_2421        ::::T::::A::V::::::E::E:::K::
Hbo2122         :S::S::::::::SN:::::::E:::A::