[S] (-) COG2138 Uncharacterized conserved protein 9 genomes BUD0666 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1093 rrnAC1289 HVO_1128 Hbo0432 Hmu1689 Hut2464 hla0272 NP1588A HQ1656A

Pairwise sequence scores
Consensus score	2248	Hut2464	VNG1093	hla0272	NP1588A	rrnAC1289	Hmu1689	HVO_1128	Hbo0432	HQ1656A
1195	Hut2464	3994	1129	1078	1122	1133	1093	1124	1145	1134
1825	VNG1093	1129	2259	1630	1724	1748	1731	1725	1689	1682
1898	hla0272	1078	1630	2229	1762	1725	1732	1782	1797	1740
2003	NP1588A	1122	1724	1762	2286	1792	1763	1881	1855	1809
1954	rrnAC1289	1133	1748	1725	1792	2256	1960	1766	1824	1769
1901	Hmu1689	1093	1731	1732	1763	1960	2245	1702	1781	1717
1995	HVO_1128	1124	1725	1782	1881	1766	1702	2243	1950	1892
2047	Hbo0432	1145	1689	1797	1855	1824	1781	1950	2237	1977
1985	HQ1656A	1134	1682	1740	1809	1769	1717	1892	1977	2240

535 symbols
consensus       --MQALVIVAHGSHLNPDSSTPTYDHADTIRATGAFDEVRTGFWKEEPSFREVLRTVEAD
#oth            12211..111....1112113.144.1111.2422.11.212....1.13.21...2121
Hut2464         MTE::::VA:::::R::::AL::LS:VEA::DR:C::Q:::A::::S::V:D::::ID:E
VNG1093         :::::::::G:::::::G::E:A:T::::::ES:::::::EA:::::::::N::::L:S:
hla0272         ::::S::::::::::::G::A::::::::::::::::::K::::::::H:::::::::G:
NP1588A         ::::::::::::::::::A::::::::::::E::V::::Q:A::::::::::A:::::S:
rrnAC1289       :MDE::::A:::::::AE::::::::::::::::::A:::ES::::::::::A::::D::
Hmu1689         ::::::::A::::::SAG:::::F::::::::VS::::::ES::::::H::::::::D::
HVO_1128        ::::::::::::::::::::A::::::::V:EA::::::::::::::::I::::::::::
Hbo0432         :::::::::::::::::::::::QR::::::::D:::::K:::::::::L::::::::S:
HQ1656A         :::::::::::::::::::::::HQ:::::::S::::::::::::::::L::::::::::

consensus       EVYVVPLFISEGYFTEQVIPRELRLDGWDVSEWDSDGLSADHATLTAEDT-DQTIHYCGP
#oth            1211....1.1...111.1...11.2321344121112213421.31412143121.11.
Hut2464         TA::::::V:Q:::VD::L:::FD:GKD:---------------:AG:P::APEMV:TD:
VNG1093         ::::::::::::::::::::::::::DF:PDD:::::TD:::V::E:D:V:EK:::::::
hla0272         :I:::::::::::::::::::::::::::::::N:::::::Q:::I:::I::REV:::::
NP1588A         ::::::::::::::::E:::::::::::ETA::::::T::T::::::A:V::K:V:::::
rrnAC1289       :::L::::::::::::::::::F::ED::PEL:::::T::TN:::A::::::::V:::::
Hmu1689         :::L::::::::::::::::::F:::E:EPEL:::::T:::T:::::::::G::::::::
HVO_1128        ::::::::::::::::::::::::::::::AD::::::::S:V::::S:VPEK:::::::
Hbo0432         ::F::::::::::::::::::::::::::::Q:::::::::T:::::::::S::V:::::
HQ1656A         :I:L:::::::::::::::::::::::::::::N:::::::T:::E:T:::G::::::::

consensus       VGTHDAMTDVIVRRAESVTGDPDVGDGFGLAVVGHGTERNENSAKAIEYHADRIREMDRF
#oth            1...41.11.212..321112452112211..........1...1.121.112222322.
Hut2464         ::::P:::::VAA::RRYLD:VP-EEDAA:::::::::::P:::D:VYD:VEAL:DHTA:
VNG1093         :::::S:SE:::Q::S::::REEF::D::::::::::::::::::::Y::::Q::::GV:
hla0272         ::::R:::::::::::::::NS:::E::::::::::::::::::::VQ::::::A:R:::
NP1588A         ::::::::::V:::::T::D::G::::::::::::::::::::::::::::::VA:::::
rrnAC1289       :::::S:S::::Q::::::::::::::::::::::::::::::::::Q::::::::R:::
Hmu1689         A::::::S::::Q::Q:::::R::::::::::::::::::::::::::::::::G:R:::
HVO_1128        ::::A:::E:L:::::T:::::N::E::::::::::::::::::::::::::::::::::
Hbo0432         ::::ES::::L:::::T::::::::E:::F:::::::::::::::::::::::V:Q::::
HQ1656A         ::::E:::::L:::::T:::::S:::EC:F:::::::::::::::::::::::V:DL:::

consensus       DEVQALFMDEDPEVDDVTDFFESDDIVVVPLFIADGFHTQEDIPEDMGLTDDYRTGYDVP
#oth            2..2111...2.111.2312.122.111....11..1..211...12.111.212.122.
Hut2464         A::D::::::A:A:E:IL:E:DA:::A::::::::::::RDE:::LL:I:::P:S::P::
VNG1093         G::::V:::::::::::::::DT:::::::::VS::::::::::::::::::::::::I:
hla0272         :::K::Y:::::::::LPE::::::V:L::::::::Y:::::::::V::CE:HTE:::::
NP1588A         :::K:::::::::I::::::::T:::::::::V:::Y:::::::::::::::::::WET:
rrnAC1289       ::::S::::::::::::A:Y::::::::::::::::::::::::::::::::::::::::
Hmu1689         :::::::::::::I::::EY::::::::::::V:::Y::E::::::::::::::::::::
HVO_1128        ::::::Y:::E::::::::Y:D:E:V::::::::::::::::::::::::::::::::::
Hbo0432         ::::::Y:::E::::::::Y::::::::::::::::::::::::::::::::::::::::
HQ1656A         ::::::Y::::::::::::::DTT::::::::V:::::::::::::::::::::::::::

consensus       ATVDGHRIWYAGAVGTEGLMADVILERAADAGADVG------------------------
#oth            23.1122...21....12.31..21...1....122111111111111111111111111
Hut2464         G::::R::::TS::::DR:VP:::::::G:::::LDRDVEQDQPVRPDAAEAFLSWLDTA
VNG1093         TA::::D:::S::::::P:A:::V:::::::::P::::::::::::::::::::::::::
hla0272         TE:::T:::::::::::P::::::::::::::::L:::::::::::::::::::::::::
NP1588A         :D::::H:::::::::::::::::I:::::::::::::::::::::::::::::::::::
rrnAC1289       T::E::D::::::::::P:::::V:::::::::::S::::::::::::::::::::::::
Hmu1689         T:::::D:::S::::::P:::::L::::::::::::::::::::::::::::::::::::
HVO_1128        :E:E:::::::::::::::::::V::::::::::I:::::::::::::::::::::::::
Hbo0432         :A:::::::::::::::::::::V::::::::::ID::::::::::::::::::::::::
HQ1656A         ::::D::::::::::::::T::::::::::::::IS::::::::::::::::::::::::

consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
Hut2464         PAENGSHSREWGDLLVTVEKDTYELRHRDDHGAAQATLTEQDAETFRWFVRTDDDGRFRP
VNG1093         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla0272         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP1588A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC1289       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu1689         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_1128        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo0432         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HQ1656A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
Hut2464         FAGERSLPTGWVLPGLNARELLRAVAAVYPAGIEMWADEPAPVSFRDVAARQTGMYAGVS
VNG1093         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla0272         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP1588A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC1289       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu1689         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_1128        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo0432         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HQ1656A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
Hut2464         DLSNTELDNLTTAVCGNCAKRREWEDGDGDLSADTAERAAVATQTTTSDLPCREPCSFVV
VNG1093         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla0272         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP1588A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC1289       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu1689         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_1128        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo0432         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HQ1656A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       ---------DAIEEVREETR----G-TAAAGD-----------------------
#oth            1111111114123611341311114344442111111111111111111111111
Hut2464         AAAREILAT:S:D:Q:PDQP::::DADVPP::LTQPANRYRVRYRQARGVTQISD
VNG1093         :::::::::::VDA:::Q:::::::AN::::::::::::::::::::::::::::
hla0272         :::::::::T:LDD:::T::::::-:-V:T:::::::::::::::::::::::::
NP1588A         ::::::::::::::::RR:KVATTDVN:S::::::::::::::::::::::::::
rrnAC1289       :::::::::S:::Q:::::G:::::G:T:::::::::::::::::::::::::::
Hmu1689         ::::::::::::QR:KS::G::::::AE:R:::::::::::::::::::::::::
HVO_1128        :::::::::NSL:V:::R::::::K::PQEAN:::::::::::::::::::::::
Hbo0432         :::::::::E::AT::::::::::E::P:::::::::::::::::::::::::::
HQ1656A         :::::::::T:::T:::Q::::::E::TL:D::::::::::::::::::::::::