[J] (NOP1) COG1889 Fibrillarin-like rRNA methylase 9 genomes BUD0691 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1176 rrnAC0865 HVO_1669 Hbo3168 Hmu1625 Hut1100 hla2286 NP2062A HQ2567A

Pairwise sequence scores
Consensus score	1587	HQ2567A	hla2286	HVO_1669	Hbo3168	rrnAC0865	Hmu1625	NP2062A	Hut1100	VNG1176
1169	HQ2567A	1635	1070	1119	1161	936	992	1060	1029	1041
1317	hla2286	1070	1608	1204	1175	1105	1103	1153	1143	1151
1371	HVO_1669	1119	1204	1659	1333	1158	1080	1157	1136	1146
1341	Hbo3168	1161	1175	1333	1614	1137	1095	1140	1111	1110
1252	rrnAC0865	936	1105	1158	1137	1603	1229	1136	1097	1095
1211	Hmu1625	992	1103	1080	1095	1229	1623	1107	1116	1067
1283	NP2062A	1060	1153	1157	1140	1136	1107	1597	1152	1099
1250	Hut1100	1029	1143	1136	1111	1097	1116	1152	1579	1156
1234	VNG1176	1041	1151	1146	1110	1095	1067	1099	1156	1584

225 symbols
consensus       MS---------LPDGVERRDFGGEER-LATRGEPVYGEPT-ADGWRAWDPGRSKLGAMFE
#oth            12333111111..3..2.161123421.2.4.311...321522..3.113.....1112
HQ2567A         :KASSS::::::::::Q::Q:DNRS:::T:H:TT:::::RDT::::L::A:::::::::K
hla2286         ::EPN::::::::A:::::EI:::T:::::::P:::::::::::::::::::::::G:::
HVO_1669        ::DDGSAADAA::::::::T:::R::::S::::::::::VDS:::::::A::::::::L:
Hbo3168         :TD::::::::::S:::::P:D:R::::S:H::T:::::RDE:::::::A::::::::::
rrnAC0865       :T:::::::::::S::::H:::::TS::::Q:Q:::::R::DGD::R:::H:::::::LA
Hmu1625         VT::::::::::::::::H:::::TG::::::::::::A::DGA::R:::D:::::::LA
NP2062A         :::::::::::::K::Q:::::DG::::::E:P:::::::::::::Q:::R:::::::L:
Hut1100         ::::::::::::::::T::A:D:TQS::::T:::::::S::SE:::Q:V:D:::::::::
VNG1176         :::::::::::::A::Q::S::D:DGV:::::::A::::V:V::::R::AH::::::T::

consensus       LGMDTGLVGGETVLYLGAASGTTVSHVADFAGPTYAVEFAPRPVRDLLEVAEPRDNLFPL
#oth            3141...4.2121......2..........1.....1...1..211.141.34.31.1..
HQ2567A         :DIE:::T:::SI:::::::::::::::::::::::I::::::::::::::TT:P::I::
hla2286         ::FE:::S:::::::::::::::::::::::::::::::::::A:::V:A:::::R::::
HVO_1669        :::::::::::S:::::::::::::::::::::::::::::::::::VG:::D:::::::
Hbo3168         Y::::::::D::::::::::::::::::::::::::::::A:::::::G:::A:::::::
rrnAC0865       H::::::G:::::::::::A::::::::::G::::::::::::::E::DA::S:R:::::
Hmu1625         :::E:::A:S:::::::::A::::::::::::::::::::::::::::DA:D::P:::::
NP2062A         TDI::::::::::::::::A::::::::::::::::::::A::A::::TA::::P::I::
Hut1100         ::V::::A:::::::::::::::::::::::::::::::::::M:::::::AD::R::::
VNG1176         ::L::::S::DA:::::::N::::::::::::::::::::::::T:::A::DS:ER::::

consensus       LKDARKPETYAHVVEP-VDAIVQDVATRGQATVALRNRQFLADDGRLLLAIKARSEDVTA
#oth            .1...5.22.1.1..32313211........5..33.21..21..1.2232.......13
HQ2567A         :C:::Q:::::::::TDIEYLI::::::::::::::::::::P::K:I:M::::::::LS
hla2286         :::::T:KR::::::SD::::::::::::::E::V::AR::::::::::::::::::::V
HVO_1669        :::::D:DS::::::AGI:CL:M:::::::::::V:::::::::::::M:V:::::::::
Hbo3168         ::::::::::::I::ADL:C::::::::::::::N::::::R::::::AV::::::::::
rrnAC0865       ::::::::S::::::::::VV::::::::::R::TL:K:::T::::::A:::::::::::
Hmu1625         :::::E::S::::::::A:VL::::::::::L::N::AR::RP::::::S::::::::::
NP2062A         :::::::D::T::::::::VLI:::::::::K:::A::R::R::::::::::::::::::
Hut1100         :::::A:::::::::::::::I:::::::::D:::S::R::R:::::VM::::::::::R
VNG1176         :::::A:::::::::SG::::::::::::::D:::S:::::::::::VA:L:::::::::

consensus       DPDAVFDDVLAELREGYEILETARLDRFHDDHLGVVARPR-----
#oth            1.22..233252.544.22432411212.2...111.2.341111
HQ2567A         ::ED:::TIIST:::::I:QTRQ::::::::::A:::T:NM::::
hla2286         E:ET::EGA:DR:::T::::::Q::::::E:::::::T:K:::::
HVO_1669        E::D:::::I:::DSA::L::::::::::A::::I::::K:::::
Hbo3168         :::D::E:::T::::A::::::T::::::::::::::::K:::::
rrnAC0865       :::::::S:R:::SAE::L:::::::PY:E::::I:::::KD:::
Hmu1625         ::A:::E:::TT:E:R:::EASES:APH::::::::::::RDGTF
NP2062A         ::::::::::E::TT::D:V::RS:E:::E:::A:::E:SGD:::
Hut1100         E:::::A::IDR:KT:::::DRQS:EPY:::::A:I:::::::::
VNG1176         ::A:::E:L:GR::D:::VRA:::MEP::E:::A:::T:::::::