[S] (-) COG2106 Uncharacterized conserved protein 9 genomes BUD0702 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1688 rrnAC1612 HVO_2565 Hbo2288 Hmu2039 Hut3008 hla0833 NP4852A HQ2843A

Pairwise sequence scores
Consensus score	2117	hla0833	HQ2843A	HVO_2565	Hbo2288	VNG1688	NP4852A	rrnAC1612	Hmu2039	Hut3008
1393	hla0833	2152	1243	1257	1267	1219	1198	1241	1260	1189
1511	HQ2843A	1243	2258	1441	1559	1298	1269	1350	1318	1316
1613	HVO_2565	1257	1441	2124	1666	1416	1326	1380	1367	1378
1657	Hbo2288	1267	1559	1666	2084	1441	1354	1429	1406	1440
1618	VNG1688	1219	1298	1416	1441	2117	1386	1430	1413	1446
1609	NP4852A	1198	1269	1326	1354	1386	2100	1422	1506	1529
1730	rrnAC1612	1241	1350	1380	1429	1430	1422	2118	1699	1551
1723	Hmu2039	1260	1318	1367	1406	1413	1506	1699	2127	1539
1691	Hut3008	1189	1316	1378	1440	1446	1529	1551	1539	2275

324 symbols
consensus       ----MTLSVLVPSSLVREAEDKREATRKLGYVARAAAVFRVDRLVVFPDRDGE-RRWGDG
#oth            11111222211...13.....3......1..1..1.2.1.2121211..23.21233122
hla0833         MRTEDG:TIC::::V::::::A::::::::::::::::::A:::::::::E:::::R:GE
HQ2843A         ::::::::::I:::V::::::::::::::::I::S:T:::::H:I:::::G:::::L:GE
HVO_2565        :::::K:::::::::::::::Q::::::::::::::::::ANE::::::E::::NN::GE
Hbo2288         ::::::::::::::::::::::::::::::::::::T:::A:::I:::::E:::::::RK
VNG1688         ::::::R:::::::::::::::::::::::::::::::::I::V:::::E:::::Q::G:
NP4852A         ::::::R::::::::T::::::::::::::::::::T:::::::::Y:::::DDG:F:::
rrnAC1612       ::::::T::::::::A:::::R::::::::::::::::Y:::::T:Y::P::A:GK:E::
Hmu2039         ::::::T::::::::::::::R::::::::::::::V:::::::TI:::PA:A:GK:E::
Hut3008         :::::::NA::::::C::::::::::::I:::::::T:::::::I:Y::P::A:G:::::

consensus       FVETVLRYAATPPYLRKEVWGRRDELEYVGVLPPLRVRSQTGSGSDGSGSLRQGIVTEVG
#oth            1.2...2..1..12...24124.1..311.1...111323.113132121121.1..1..
hla0833         Y:R:::G::::::E:::DL::E::::R::::::::::PWR:::TPS:EE:KT::L:::::
HQ2843A         :::::::::::::H:::KI::::::::::::::::::S:T:::E:TD::::T::::::::
HVO_2565        :::::::::::::::::::::K::::R:A:I:::VL:A:T:ADD::E:PA::E:::::::
Hbo2288         :::::::::V:::::::::::H:::::::::::::L:S:T:::E::D::::Q::::::::
VNG1688         ::::::::::::::::::AFDT::::A:A:::::::LS:W:::D:S:::::::::::Q::
NP4852A         ::S:::E:::::A:::::::D::G::::A:I:::::::::::::::::::::::::::::
rrnAC1612       :::::::::::::H::::M::K:::::::::::::::::::::::E::::::::::::::
Hmu2039         :::::::::::::::::::::K:::::::::::::::::::::::E::::::::::::::
Hut3008         ::::::::::::::::::A:E:::::GC:::::::::AT:::::::D:::::::::::::

consensus       PDGRVRVNCGM-QHPISLPVPPDMEV-EEGERVTIRVSSREPVRAKIVDEPLPGFDVDRA
#oth            211.....12111..1..52.43252152.1..11.1...1....11115143.14.343
hla0833         :E::::::SPLRE:::::L::SG:::::Q::::::::::::::::R:TGK:EE::Q:VE:
HQ2843A         ::D::::::EL::::V::H::ESVS::R::T::A::I::::::::R:::T::S::::SCL
HVO_2565        ::D:::::::::::::::F:::G:DL:T:::::AV:I::::::::R:::::::::::S:M
Hbo2288         ::::::::::::::::::YT:S::M::K:::::A::I::::::::R:::::V:::::S:M
VNG1688         SE::::::::::::::::HE::G:A::S::::::::::::R:::::L::D:::::S:E:T
NP4852A         ::::::::::::::::::::::S::::GK:::::::::::::::::L:::SP:::A::C:
rrnAC1612       A::::::::::::::::::::A::D:::Q:::::V:::::R:::::L::A:TT::::VA:
Hmu2039         A:::::::::L::::::::::SA:::PG::::::V:::::R:::::L:::::T:YV::T:
Hut3008         S:::::::::::::::::A::G:RTI:K::::::V:I:::R::::::::Q:P::YQ::::

consensus       DLDAALERADAGVRIATSRHGEPLSVDRLGDLAER-DAAGGMTVAFGAPERGLPAILG--
#oth            32531.52321.321.2..2.2312263.3424423562424.11..1.1....511111
hla0833         ::SE::--:GD:LAV:::::::E:::S::::IVSDARK:::Y:::::S::::::EM::::
HQ2843A         ::VD:::H:A::ITV::::::DTVTTG::PE::A::VNRA:A:I:::::G::::V:::DD
HVO_2565        ::TE::G:P::::::::::Y::::::PT::::TA:ITD::::::V::S:G::::DM::::
Hbo2288         ::EE::G:::::IT:::::F::S:T:PK:A::SP::IERE:A::V::S:G::::D:::::
VNG1688         G:GD::D:S:::::::::::::::::AS::GYR:::I:RD:V::::::::::::PM::::
NP4852A         TIE:S:A:P:::::::A:::::T::::::DGIVG::TT:N:F::::::::::::E:::::
rrnAC1612       ::::::S:D:::LT::S::Y:::VTST:::Q::::R::E:::::::::::::::S::D::
Hmu2039         :V:T::::S:::FA::A:::::E:G:::::Q:V::R:D::H:::::::::::::::F:::
Hut3008         N:::::S:P:::::::A::::QS:TTE:::R::GTIAS::D:::::::::::::::::::

consensus       -------------VSPDAVDP---------------------DEPSDGP-GFDLWLNTIP
#oth            111111111111144144376323111111111122122222353524231..1....1.
hla0833         :::::::::::::L:::GIRAAVAD:::::::::::::::::GRSVEPDP::::::::::
HQ2843A         NAPDSQTQTDEKT:::AN::TT::::::::::::GDNTASEVV::NVD::::::::::::
HVO_2565        :::::::::::::MP:ED:AD:::::::::::::::::::::V:::V:::::::::::::
Hbo2288         :::::::::::::IDAEE:T-:::::::::::::::::::::V:::::::::::::::::
VNG1688         :::::::::::::::A:::NESVT:::::::::::::::::::SSA:A:AR::A::::::
NP4852A         :::::::::::::CE:REE--:::::::::::::::::::::AIGDEPEAR:::::::V:
rrnAC1612       ::::::::::::::A::::GG::::::::::::::::::::::QT::E:E::::::::V:
Hmu2039         :::::::::::::LD::DAV:::::::::::::::::::::::GTG:DDA::::::::V:
Hut3008         ::::::::::::::E:G::::STVDELAAAVDAAERNDETVTGSG:::::R:::::::V:

consensus       NQGSEVVRTEEAMFATLASLTLTE
#oth            4.1.........2111.23..111
hla0833         A:A:::::::::L:V::G::::::
HQ2843A         Q::::::::::::::S::L::I::
HVO_2565        R::::::::::::::S::::::::
Hbo2288         R::::::::::::::S::::::::
VNG1688         D:::::::::::VL:::G::::::
NP4852A         ::::::::::::L:::::P:::E-
rrnAC1612       ::::::::::::L::S:TC:::::
Hmu2039         ::::::::::::::::::::::::
Hut3008         :::::::::::::::::GP:::::