[R] (-) COG1407 Predicted ICC-like phosphoesterases 9 genomes BUD0713 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1252 rrnAC1137 HVO_1336 Hbo0215 Hmu1441 Hut1238 hla2673 NP3964A HQ2403A

Pairwise sequence scores
Consensus score	1908	HQ2403A	NP3964A	hla2673	VNG1252	Hut1238	rrnAC1137	Hbo0215	HVO_1336	Hmu1441
1215	HQ2403A	2217	946	1026	954	937	1049	1127	1004	1001
1225	NP3964A	946	1865	995	949	1062	1043	996	1028	1104
1357	hla2673	1026	995	2082	1054	1101	1066	1182	1175	1084
1252	VNG1252	954	949	1054	1901	1080	1083	1022	1059	1155
1372	Hut1238	937	1062	1101	1080	1909	1205	1156	1193	1256
1362	rrnAC1137	1049	1043	1066	1083	1205	1914	1168	1179	1189
1461	Hbo0215	1127	996	1182	1022	1156	1168	2041	1268	1155
1469	HVO_1336	1004	1028	1175	1059	1193	1179	1268	2007	1179
1403	Hmu1441	1001	1104	1084	1155	1256	1189	1155	1179	1899

305 symbols
consensus       --------------PLVEPVPGEPAAVADTGD----ERALVVADYHAGIEAGLRYE-GVE
#oth            11111112333344351..2325.1.2144452222214.21..1.....31..321.1.
HQ2403A         MPTDTDTDTDAATG:::::L:SV:::I:RIET:::::T:::I::::::::I:::::R:::
NP3964A         ::::::::::::::-ML:::F:::L::::C:P::::::V:::::::::::V:::AD::::
hla2673         ::::::::MAPGAS:A::::V::::::::L::::::R:L:L:::V:::::V:::::R:::
VNG1252         :::::::::::::MA:::::L:::::::E::G::::G:::::::::::::VS::RK::L:
Hut1238         ::::::::::::::MA::::::A:::TVEVP:::::G:::::::V:::::::::K:::::
rrnAC1137       ::::::::::::::MR:::L::V:::TV::DG::::::L:A:::::::::::::::::::
Hbo0215         :::::::MARRGDG:I::::::D:::::HL:PNAGD:T::::::::::::::::::R:::
HVO_1336        :::::::::::VPE:::::I::H:::::R:SRRGFP::S:::::::::::::::::R:::
Hmu1441         ::::::::::::::MG:::::DS:::::T::E::::::C:::::::::::R:::R:::::

consensus       LDSAADVRRERLLSLLAETDADRLVVLGDLGHRIGAPAGDEREELRALFDAVTDRVPVTV
#oth            1515135.1311252243362..1221..2112.14.643.23.26514533542114.1
HQ2403A         :::N:ED::R:::E::TQHPV:::II:::A:::::N::DE:TQ::MS::TS:LN:::I::
NP3964A         :R:::EK::K::::AIESELV::CLF:::::DS::S:SRT::A:::E:LS::::H:::::
hla2673         :::R::E:::::CG:I:::::::::I::::A:::A::E:::::::VE:IR:::::::M:L
VNG1252         VEGRGPQ::R::RR:VR:EG:::::::::V::A::::EEA:::::A::::::D--::A::
Hut1238         :A:G::Q:::NV:::V::::P:::I:::::::A::T:QR:::::IDR:VSEI:E:::L:L
rrnAC1137       :Q:::EA::::::TC:RRAR::::::I:::::A::D:FA:::A::ET::::LD--::::L
Hbo0215         :::D::::LA:::R::D::NP::::::::::::::::K:::AD::ETFVERTVA:::I:L
HVO_1336        :P:K:A::::::::::DR:::::::::::::::::D:D:::A::::D:AA::A::TEL::
Hmu1441         :A:D:::::A:::D:::::AP:::::::::A:S::D:::A::::VT::L:::E--:::::

consensus       VRGNHDGGIEEVFADD----------VNVTDGSGVRLG--------------SVGFAHGH
#oth            14....212234552533211111112412234.432.111111111111114..13...
HQ2403A         ::::::A:::S:ATTVETDSTQIEHTI::::A::IKC:::::::::::::::H:::V:::
NP3964A         TK::::::::SITEAFDA:::::::::::V::R:TTI:::::::::::::::::::C:::
hla2673         :E::::A:VA:A::::::::::::::LD:IGAG:GV::GDGGERDDDTTTGTG::VL:::
VNG1252         :V::::S:::D:VPA::::::::::::T::PSD:AV::::::::::::::::D:::::::
Hut1238         :K:::::E::SLL::REG:::::::::AI:::::::::::::::::::::::::::::::
rrnAC1137       :K::::::L:P:LS:LDAD::::::::E::P:H:T:::::::::::::::::::::::::
Hbo0215         :::::::::A:A:G:R::::::::::ID::::::I:::::::::::::::::R:::V:::
HVO_1336        :P::::::LADF:G:::::::::::::E:::PG:::::::::::::::::::D:::C:::
Hmu1441         :::::::::D:LC::AATP::::::::T::PSD:::I:::::::::::::::::::::::

consensus       TWPSREVLEADVVCVGHEHPAVRLEDEVGGSRKERAWLRGPLDPAPFAEHDD--------
#oth            1..3441232112141....31.12.4...4132.1....433243.6456333111111
HQ2403A         S::DET::DC::L:::::::QL:VA:H::::QQT:::::::::WT::KNKLGIERSFDSP
NP3964A         ::::AS:IG::::V::::::L:::::::::G:T::V::::RI:::G:PDN:T::::::::
hla2673         :::NP:L:D:::::M:::::Q:::::A:::::V:::::::E:::TA:VKDGEVD::::::
VNG1252         :::::A::::ET::I:::::::::T:D:::T:VQ:::::::::::::TD:YG::::::::
Hut1238         :::APD::A:ET::I:::::V:::::::::R::::V::::AI::V::R::::::::::::
rrnAC1137       :::APD::::::::::::::V:::::S:::AQ::::::::S:VTE::::QF:::::::::
Hbo0215         ::::C::V:SE:::AA::::::::A:S::::::::::::::MN:D::::ALGLD::::::
HVO_1336        ::::::::A:::::SA::::::::::::::A::::V::::A:A:EV::::HEVV::::::
Hmu1441         :::::A::G:::I:::::::V:::::::::R:V:::::::RV:::::ESQS:::::::::

consensus       ----EAARADPDLVVFPAFNDRSGGTWVNVDGQEFLSPFLPDGLAD--GDAYLLDGTRLG
#oth            1135654755322211....12....21.23222..1....21432112211.1......
HQ2403A         DNTQNVN:DP::VIL:::::E:::::Q::T:-EG:::::::AAFEKNHT:::::::::::
NP3964A         ::::----VGDR:::C::::E:::::RI:-ERD:::::::::::::::::::::::::::
hla2673         :::PA::TDP:E::::::::E::::::::::::S::A:::::A:PA::::::::::::::
VNG1252         ::::::VD:HG::A:::::::L:::::::::::G::A::::A:CP:::AEL::Q::::::
Hut1238         :::DTRLQV:GE:::::::::L:::::I::A::S:::::::E:::::::T::::::::::
rrnAC1137       ::::QPVENA::I:::::::::::::::::::::::A::::E:M::::TE:F::::::::
Hbo0215         ::VV:L:WQS:E::::::::::::::::::E::::::::::::VF:::A:::::::::::
HVO_1336        ::PA:V::::AE:::::::::T::::::::P::G:::::::::::::::E::::::::::
Hmu1441         ::::G:LGI:A::::C::::::::::::::A::::::::::A:::::::E::::::::::

consensus       PYRSV
#oth            31241
HQ2403A         ::Q::
NP3964A         :::D:
hla2673         DF:RI
VNG1252         RFDR:
Hut1238         ::DQI
rrnAC1137       A::Q:
Hbo0215         :::::
HVO_1336        D::N:
Hmu1441         R:::I