8 genomes BUD0799 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0153 rrnAC1481 HVO_1202 Hbo0357 Hmu1925 Hut0545 hla0047 NP2546A NP2684A -

Pairwise sequence scores
Consensus score	2711	HVO_1202	VNG0153	NP2546A	NP2684A	hla0047	Hbo0357	Hut0545	rrnAC1481	Hmu1925
1496	HVO_1202	2754	1219	1197	1210	1289	1393	1334	1314	1295
1983	VNG0153	1219	2718	1653	1717	1641	1748	1730	1704	1770
1995	NP2546A	1197	1653	2684	1819	1705	1728	1802	1736	1789
2065	NP2684A	1210	1717	1819	3239	1660	1804	1876	1799	1882
1915	hla0047	1289	1641	1705	1660	2638	1776	1766	1773	1781
2135	Hbo0357	1393	1748	1728	1804	1776	2676	1885	1846	1908
2251	Hut0545	1334	1730	1802	1876	1766	1885	2798	2106	2131
2195	rrnAC1481	1314	1704	1736	1799	1773	1846	2106	2719	2270
2283	Hmu1925	1295	1770	1789	1882	1781	1908	2131	2270	2748

439 symbols
consensus       ------------MSDDAADDDGGDDTEESVDE----------------------------
#oth            111111111112132153236746466466554533111111111111111111111111
HVO_1202        :::::::::::::TN:::TAN:T:A:P::GER::::::::::::::::::::::::::::
VNG0153         ::::::::::::::::TE::S::ES:ADMEFG::::::::::::::::::::::::::::
NP2546A         ::::::::::::::::STEEPDE:T:::PDEDTTEA::::::::::::::::::::::::
NP2684A         MTPNEEPAGRGLST::T:EGERTR:GH:TATGEQPQDHYGTTDGNVTSGRDRAERGRTRT
hla0047         :::::::::::::::EEST:IN:T:-------::::::::::::::::::::::::::::
Hbo0357         :::::::::::::AE:GT:E:ASF:D:TA---::::::::::::::::::::::::::::
Hut0545         :::::::::::MSD::ET:::PPS:A::TT::SADA::::::::::::::::::::::::
rrnAC1481       :::::::::::::::ED::::T:SESDAG:SSDG::::::::::::::::::::::::::
Hmu1925         ::::::::::::::::::::ASTG:QS:::::ESPV::::::::::::::::::::::::

consensus       -------------------------------EAPVPVGVKLGSTRTVIAFPGDDG-EDET
#oth            1111111111111111111111132222222544412...2..1..22662454224633
HVO_1202        :::::::::::::::::::::::::::::::D::TA::::F::A::TLV:--:::DAAT:
VNG0153         ::::::::::::::::::::::::::::::::Q:A:L:::V::::::V:--E::ADSPSV
NP2546A         :::::::::::::::::::::::::::::::TEGAA:::::::::::LKT-----:D:TV
NP2684A         ADEVTEPAGRTSGEAQRRDDVGTAKAEEAAD:SV::I:::::::::::TY:SQS:DGM:V
hla0047         :::::::::::::::::::::::::::::::-G:EA:::::::::::LDI:DGR::GR:R
Hbo0357         :::::::::::::::::::::::::::::::KG:T:::::::::::ILQ:YDG:::DL::
Hut0545         :::::::::::::::::::::::TDESTDEDAETL:::::::::::::SY:::::::M::
rrnAC1481       :::::::::::::::::::::::::::::::A:A:::::::::::::::L::EH:T:NQI
Hmu1925         :::::::::::::::::::::::GD:::::A::A::I:::::::::::SV::AR:T:::I

consensus       IRTLTCLATYEDALTGEERVLYGEEAAREYPDRVEFMLRSGLPEDDDRAELAERFFEALV
#oth            43311.11111.111.2.3122122.15111.3121.....1.13225224222.13234
HVO_1202        VQVPS::VDG::::P:D:::SDD:G:V:RSG::A:::::::V:ATARD:::F:::VRE:C
VNG0153         TQ::::::::D:::::::H:I::A:::T::::::R::::::::::EETTG::K::::EFA
NP2546A         DKM::::::::::::::::I::::::::::::T:RY::::::::::EN::A:AK::Q:V:
NP2684A         VQS:::::::::L:::R:QI::::::::::::E:::::::::::S::SV:S:AT::SE:L
hla0047         HS:::::::::::I::D:K::F:H:::I::::T:R:::::::::::ESVAD:::::::V:
Hbo0357         V:::::::::::::::D:::::::Q::Q::::S::Y::::::::N::G::::KK::SE::
Hut0545         :::::::::::::::::::::::::::E::::::Q::::::::::E:G:A:T:::::S::
rrnAC1481       :K::::M:::::::::::KI:::::::::::::::Y:::::::::A::::MTKT::::II
Hmu1925         ::::::::::::::::::K::::::::A::::::Q::::::::::E:::::T:T::Q::I

consensus       EANDLPEDSAVVYAIPTIDNEAGLANLESVIENSPIGDALVRSYPESLCGAIPAFGDDLE
#oth            44112134.2....2..21124.2511752115332.5532222.....112.1212322
HVO_1202        :RH:::AE::::::M::V:DRV::::FGTAVGECGL:GT:T:GL:::::AS:::L::GI:
VNG0153         S::G:DT::V::::::::::::::DR:AEI::DG:V:ERRIA:::::::::V::L::G:D
NP2546A         ::::V::A:G::::V::ME::::IR:::::::SAA:::VFT:A::::::::V:V::-GV:
NP2684A         A:::V::N:V::::::::::::::S:::A:V:K::::E:::::::::::::L:::EER:A
hla0047         D:H:V:::::::::V::::::::VN::K::::G:S::QVET:::::::::::::Y::::D
Hbo0357         N::G:DG::::::::::::::P::R::NR:::E::V:::::::F:::::::::::::E::
Hut0545         :VH:I::::G:::::::::::::::::R::V:::A::G:FIE::::::::::::::::::
rrnAC1481       :EH:I:AN:G::::::::::PT::E::QN:::::S::LD::E::::::::S:::::::::
Hmu1925         DQ:::::Y::::::::::::PQ::E::T::::G:S::KH::E::::::::::::::::::

consensus       AIDEIFVAINMGSTNLEACAYRRGEQLAPFSTGAVTGNEVDRRIANYVEEETQGRVNIDL
#oth            .2222.32211.1.1...1.1.1.12.3.2311321.311..2.2311.1.11..121.4
HVO_1202        :V::V:::LDL:P:::::::::H:TR:L::VSAE:S:DR::::::EA::A::E::AT::P
VNG0153         ::EDT:::::::::::::::::::::::::::::I::T::::::::::::::::::::::
NP2546A         :L::::LS::L:::::::::F::::A:::YA::G:::S::::::VS:I:::::::::V::
NP2684A         ::ND::IT:::::::::::::::::::V:L::::T::::A:::::::::::::::::::R
hla0047         ::::V::S::::::T::::::::::::S:::::S::::::::::VAA::::S::::H::R
Hbo0357         :::SV:A:::::::::::S:::H::::S::VS::::::::::::::A:::::::::::::
Hut0545         ::N:::I:::::::::::S:::::::::::T:::::::::::Q:T::::A:::::::::T
rrnAC1481       ::::::::V:::::::::S::::::::S::T:::::::::::M::::::::::::::::N
Hmu1925         ::::::L:V:::::::::S:::::::::::T:::::::::::M::::::::::::::::T

consensus       TTAREYKEEHADFDDFEPFTDVIQQP----GGGSHEFTIERSVMDAVDEYLDDAVDEVAN
#oth            2.......3..11531.1.1.211111111.1.31...1122.12121212.21.22211
HVO_1202        D:::::::T::::GG::::::AVERGDGDG:D:V::::V::G::EPL:D::::::T:LSD
VNG0153         ::::::::Q::::N:Y:::S:I:::::::::::TY:::::DA:::::::FV:A:::::::
NP2546A         :::::::::::N::A::::::::::::::::::A::::::D:::::C:::::EV::A:::
NP2684A         ::::::::K:::::S::::::::::::::::::T::::::E:::K:C:::::EV::::::
hla0047         ::::::::::::VY::::::::::::::::::::::::VD:G:REP::R:I:E:::V:::
Hbo0357         :::::::::::::::::A::::::::::::::::::::::::::EPL:D:::::::::::
Hut0545         Q::::::::::::EG:::::::::::::::::::::::::::::::::::V:EV:::F::
rrnAC1481       Q::::::::::::V:::::::I:::::::::::::::::::::::::N:::::::::L::
Hmu1925         Q::::::::::::V:::::::I:::::::::::::::::::::::::::::::::E::::

consensus       TFLPELANDYMKVYQLALDRPIVLTGGMACIPGIVDEFERRLSEELDRDVEAIAADRPDL
#oth            5.123..1211.3..2.1331113....1....213.114.122112.213233214.32
HVO_1202        -:FSR::SSH::T::::RA::L:V:::::::::L:A:L:S::AA::::P:DVVVP:D:TT
VNG0153         V:::D::S::V:I::Q:::N::::::::G::::::S:::T::G::I::E:::TT::E:ET
NP2546A         E::::::::::::::I:::ET::::::::::::L:::::::::D::Q::IK:D:::::::
NP2684A         G:::::::N::::::::::K:L:::::::::::V:::::::::D::Q:::T:VS::::::
hla0047         E::::::::H::P:::::G:::AA:::::::::LTE:::K:::A:::::::VVSP:D:AT
Hbo0357         N::AQ::::H::P:::::SK:::::::::::::::E:::T:::::::::::C::::::::
Hut0545         :::::::::H::::::::::::::::::::::::::::AE:V::A:N::::V::SEN:::
rrnAC1481       ::::::::::::::::::::::AI:::::::::::::::E:::A::N::IDV::::E::I
Hmu1925         :::::::::::::::::::::::::::::::::::E::::::::::N:EI::::::Q::I

consensus       AAAEGAQRIAERLADSN--
#oth            .115..411.62.546532
HVO_1202        :::A::H:L:V::R:R:AT
VNG0153         :::R::H::::::V:LGEY
NP2546A         ::::::HE::SQ:LKHQS:
NP2684A         :::Q::YE::DH::Q:L::
hla0047         ::::::G:::G::I---::
Hbo0357         :P::::R:::::::K--::
Hut0545         ::TV::::::T:::::Q::
rrnAC1481       :PTI::::::A::VET:::
Hmu1925         :PTI:::::::::GENA::