[H] (ApbA) COG1893 Ketopantoate reductase 8 genomes BUD0813 8 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0730 rrnAC3068 HVO_0068 Hbo1432 Hmu2767 Hut1596 hla0243 NP0942A -

Pairwise sequence scores
Consensus score	2181	VNG0730	NP0942A	Hut1596	rrnAC3068	Hmu2767	hla0243	HVO_0068	Hbo1432
1050	VNG0730	2200	805	887	815	841	783	816	832
1503	NP0942A	805	2202	1208	1223	1249	1115	1224	1209
1489	Hut1596	887	1208	2147	1295	1334	1150	1232	1223
1515	rrnAC3068	815	1223	1295	2147	1398	1047	1192	1248
1576	Hmu2767	841	1249	1334	1398	2217	1138	1220	1287
1480	hla0243	783	1115	1150	1047	1138	2275	1281	1281
1634	HVO_0068	816	1224	1232	1192	1220	1281	2160	1500
1587	Hbo1432	832	1209	1223	1248	1287	1281	1500	2182

318 symbols
consensus       MRIVVFGAGSLGSLVGGLLA-REHDVTLVGRDP-HVSRVREDGLRI---DGAIEAHVRPA
#oth            .21213.1.1..1.1.11..12213.1.111221.3542433.1411115.245343524
VNG0730         ::V::Q:P:::::::::V::GG:TA:::L:HQSE:LT::::::::VVQP::TTRVTRPSV
NP0942A         :::TI:::::::::::::::::::::V:::::::::::S:DS::T::::::ELATT:QLD
Hut1596         :DV:::::::::::I:::::::::V::::::ED:::HA:Q:::::::::T:E:Q:V:::R
rrnAC3068       :D:::V:::::::::::::::::::::::::E:::::Q:T:R::SV:::V::E:FR:H:N
Hmu2767         :E::::::::::::I:::::::S::::::::E::::GT:ERS::A::::E:::D::::::
hla0243         :EVL:Y:::A::::::::::::V:E::::::::::MR:I::::::::::::E:::::::R
HVO_0068        :::L::::::::T::::::::SV::::::A:::::AA::SAA::D::::I::GS::IS::
Hbo1432         :DVL::::::::T:::A:::::V::::::::::::::H:::R:VTV:::S:::::QTA:D

consensus       ATTTSPG-RADLAVVTVKAYDTAAAAAALS-DCDLDAVLSLQNGLGNEATLAARLDA-PV
#oth            .5344453311.12111112..321131.21333611111....211134.13514312.
VNG0730         ::DP:VVAD:::V::C::S::::S::R::GRQ::GAM::T:::::::A:V::EHVP:DT:
NP0942A         :RRDV:D::VG:::IC:::F::TT::E::::GA:I::C::::::::::::::DQ:AV:::
Hut1596         :SK:VS::A::::I::::S:::P::VE::::G::C:::::::::M:::ER::SLV-::T:
rrnAC3068       :Q:AM:E::::::L:::::::::TV::D:A:::T:::C::::::M:::SQ:::V::C:S:
Hmu2767         :G::::A:A::::::::T:G::D:::::::::TA:::C::::::M:::::::E::GC:::
hla0243         :L:DGTHRS:::::::T:::::D:::R::A:TGEY:::C:::::F-T:ER:V:A::P:T:
HVO_0068        ::::DT:HS::::L::::SF::::::D::A::::V::::::::::-T:E:::S:::::::
Hbo1432         :::E:D:H::::::::::SF::PT:::::::TGAF::::::::::-T:DE::::::::::

consensus       LAGTATYGARLREPGRVACTGVGEVVLGARDGGQDPLADRVGAAFRDAGIETTVAADMPR
#oth            .1..211..2351..4.321.3.2212.334.16244131214..43113211.141111
VNG0730         :V::T:H::ART:::V:RHA:G::TTI:RYR:AN:ARVAS:A:::STG:M::::T:SPQ:
NP0942A         ::::C::::L:ES::T:T:::R:T:::::::::SL:::::::D::AT::LDV:::E::::
Hut1596         :::::::::LQD:::S:R:::I::I:::PP::::STI:::I:E::ST:::::::::::::
rrnAC3068       ::::CS:::::::::T::F::R::::::E:N:::SAV::S::::::A::::::::::::T
Hmu2767         ::::C::::::T:::V::::::::::::P:E::RSEP:::A::::T:::V:::::D::::
hla0243         :::::S::::FI:::::T::::::::V::LS::D::::K:::S::DE:E::::::T::::
HVO_0068        :::::::::::V:::::E:::::RI::::L:::P::::E:::K::::::LN:L::T::::
Hbo1432         :::::::::::::::H:E:::I:R:::::::::T:RR:E:::K:::::::::L::S::::

consensus       RLWEKLAVNAGINATTALARVENGALAD-GPGGAVARRAARETARVARAEGVDLPDERAV
#oth            121..11..1...131..1113..11431312643143.11.211..1341121243414
VNG0730         AV:::VL::V::::A::::D:D::::VECP::ER:LE::VT:GV:::E::::SVS-:SV:
NP0942A         :::::::::::::::::::::D::V:CS:DD:N:::TA::::::A::::T:I:::TST::
Hut1596         :R::::::::::::::::S::P::::S::::LSD::::::::::::::DH:::::::A:I
rrnAC3068       ::::::::::::::V::::::::::::::S:AD:I:AD::::::A:::EQ:I::::::::
Hmu2767         :::::::::::::::::::::P::::V::::ARR::E:::::::A:::EH:::::::::A
hla0243         :RY::::::::::GPS::::LS:::TL::::::EA::E::::V::::::D::T:DEDA::
HVO_0068        :R::::::::::::V::::::::::::G:DDA:EL:H:::::::::::L:R:S::NRV:R
Hbo1432         ::::::::::::::V:::::::::::::::::HQL:H:::::::::::::::S:SNR::E

consensus       EAVERVAADTAANRSSMLQDVAAGRRTEVDAINGYVVDRADDHDVEVPTNRTLAALLRAW
#oth            53333.134.12.3...32.243231..11113.2122436433441.1211124.2.31
VNG0730         :RARQ:::R::S:E:::R::L:G:A::::ESLH:A::E::R:::IA::VI::::D:V:LA
NP0942A         ::T:::::T::::V:::R:::RD:::::::::::::::KGNEFG::T::::::CR:::::
Hut1596         A:L:S:VDA::D:E:::YR::QS::::::E::::::A:S----:::T:V:E:::::::G:
rrnAC3068       SL::::VD:::::H:::Y::IS::QQ::I:::::::AET:TER---::V:E:::G:V:T:
Hmu2767         QIAMQ::T::::::::::::::D::Q::I:::S::::E:SG--G:A::V:E::T::V:::
hla0243         D::::::::::::::::CE::::D::::::::Y:AAI::::RFG:P:::C:AI:S:I:::
HVO_0068        :::D::VEK::::::::::::::EK:::::::::A:::I:A:::F:::::::::::::::
Hbo1432         R:LDE:VEA:S::::::::::DDE:::::E::H:V::A:::A:RLS::::::::D:::T:

consensus       ERGRGLR-----------
#oth            133544242222211111
VNG0730         Q:DG---:::::::::::
NP0942A         :::::::P::::::::::
Hut1596         ::ESK:GK::::::::::
rrnAC3068       ::H:ER-:::::::::::
Hmu2767         :DENSTGRRYSSH:::::
hla0243         :V:I:V:PGEDTTKASEE
HVO_0068        :::A::::::::::::::
Hbo1432         :A:::V:E::::::::::