[NU] (VirB11) COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis 8 genomes BUD0817 8 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0823 rrnAC0466 HVO_1034 Hbo0528 Hmu1138 Hut0470 hla2295 NP3106A -

Pairwise sequence scores
Consensus score	4190	VNG0823	NP3106A	Hut0470	rrnAC0466	Hmu1138	HVO_1034	hla2295	Hbo0528
3175	VNG0823	4303	2598	2727	2714	2682	2657	2695	2644
3168	NP3106A	2598	4199	2685	2735	2790	2661	2763	2704
3301	Hut0470	2727	2685	4240	3088	3114	2657	2694	2658
3267	rrnAC0466	2714	2735	3088	4120	3333	2602	2610	2577
3284	Hmu1138	2682	2790	3114	3333	4143	2670	2622	2683
3093	HVO_1034	2657	2661	2657	2602	2670	4218	2924	3099
3256	hla2295	2695	2763	2694	2610	2622	2924	4221	3194
3214	Hbo0528	2644	2704	2658	2577	2683	3099	3194	4891

652 symbols
consensus       ---------------------------------------MARRETDEAGDLSGD------
#oth            111111111111111111111111111111111111223445554545156445433332
VNG0823         ::::::::::::::::::::::::::::::::::::::::VT:LNAPV:AMA::LFAGLD
NP3106A         :::::::::::::::::::::::::::::::::::::::::SNH::SR------::::::
Hut0470         ::::::::::::::::::::::::::::::::::::MSEPH::TDQ:::T:::TATSTAE
rrnAC0466       ::::::::::::::::::::::::::::::::::::::::SNP::P:P::FVS:P:::::
Hmu1138         :::::::::::::::::::::::::::::::::::::::::GD::EHD:SS:TP::::::
HVO_1034        :::::::::::::::::::::::::::::::::::::::-M:DPSV:R:V:RLLASGEFD
hla2295         ::::::::::::::::::::::::::::::::::::::MASDARE:D:::R---::::::
Hbo0528         VTYRNEDAMSETEFDLGDTGEQADAASDGDAGATASPNDG:DSPN:DN::P::FE:::::

consensus       -------LAALRRRLSRTAEVLRGSAVDVRNYDPSDHGPLVEFDGPAGYDEVDRYWLNAP
#oth            1111123345333312.2222.3.242236222.42233143254222451111..1...
VNG0823         :::::GGFD::Q::A::IV:::::T::::PP:::QA:::::::::V:D:E::::::V:::
NP3106A         ::::::::ES:::Q:R::::L:Q:TT:PGGA:R::::S:I:GDHDVD:-RV::Q::::::
Hut0470         ADESVGR:GSAKEW:V:V:R::A::Q:A:E::::RR:DH:TD:G:L::M::I::::::::
rrnAC0466       ::::::::GHIQSW:::::T::S::::PTA:::::R::T::::::LD::N::E:::::::
Hmu1138         ::::::::SGV:DW:::::RM:S:A::PST::::QR::K:::YTV:EQ:::I::::::::
HVO_1034        :::::AAA:EAE:L:R::::M::::DL::HPLS:D:-T::GTYEV:E:HE::E:::V:::
hla2295         :::::::IE:::::::::W::::::DI:::AFR:G:D:::AD:AI:D:ES::::::V:::
Hbo0528         :::::AA::D:::::R:::::::::RI:::P:R:::-:T:ST:EP::DEAVI:Q::V:::

consensus       FAFAVINYDPEADEHRYHVVEPDLDDFERDLLDRLFEDIRDPLLYREDTDEDP-EAALRA
#oth            1111213214332415.221..4.121.332.12132.1.31.1.344325431.42.44
VNG0823         Y::VF:GF:A:S:T:Y::::::H:::::QTV::Q:YD::::A:I:DAT::P:DR::V:I:
NP3106A         :SY:::S::ETESQ::::AI:::::R::S:::ET:YD:V:A::::-:KR::P:::E:::Q
Hut0470         Y:::S::::::R::::::::::G:::::::::::::::V:::::::A:V::::::G::L:
rrnAC0466       ::::S::H::DR:::L:Q::::S:T:I::E::::::::::I::I::D:V:T::::RV:AE
Hmu1138         ::::S::H::::::QF:Q::::S::E::::::::::::::G::I::::VSD:::::::A:
HVO_1034        ::YV:VT::TD:TA:Q::T::::::E::AS::E:VRT:::::::::REA:PRT::T::VE
hla2295         Y:YV::T:HDAES::::YA:::E::R::::::::VVD::::::::::G:GRTD::ET::T
Hbo0528         Y:YV::T::EA:SK:C:YA:::::::::::I:E:VR:::::::::NTE:GSSA::TT::R

consensus       ELRRRLEEYGVDVEMETFHRLFYYLYRDFQGYGRIDPLMHDPHIEDISCDGYDLPIFVYH
#oth            31253122.13324331112.2...4.4.4.1132..214.12...1....14..112..
VNG0823         QMQ:L:S::SI::TPNA::::::::H:T:E:FEKL::V:Q::::::V:::::G::L::::
NP3106A         ::::::QQ::TNIDTA:VY::::::::R:::F::L::::Y::::::::::::E::LYI::
Hut0470         :::D:::::::::RI::V:::::::F:E:::::K::::::::A::::::::AS:::::::
rrnAC0466       ::EA:::::::VI:P:::Y::::::H:S:::::H::::::::D::::::::AN:::::::
Hmu1138         A::D:I:::::V::P:::Y::L:::::S:L:::::::::::::::::::::AG::::A::
HVO_1034        ::QSI::Q::LELD:N::YT:L:::R:::H:::PL::::K:::::::::::::::L::::
hla2295         ::EGL::G::::IG:D:::A:A:::::::R:::KV::FLN:R::::::::::::::::::
Hbo0528         T::TV::Q::IE:::A:::T:L:::L:::R:::::::::Q:::::::::::::::::A::

consensus       DDYTDIETNITFDEDELDNFVIRLAQRSGRHISVGDPVVETTLPDGSRAELALGEEVTPR
#oth            13.1.11111213442.2321111..1..1.1.121.222...12.1.1.....1....1
VNG0823         T::::::::::YEQQ:::S::V::::Q::::::I::::T:::::::::::::::::::::
NP3106A         :::Q:::S:::::R:::::YI::M::Q::::::::N:I:::::Q::::::::::::::::
Hut0470         :A:::V:::::Y::S::E:L:VQ:::::::::::A::::S::::::::I:::::T:::::
rrnAC0466       :G:::::::::Y:A:::ND:::Q::::::::V::S::::S::::G:::I:::::::::::
Hmu1138         :A::::::SVVYE:G::ND:::Q::::::::V::S::::S::::::::I:::::::::::
HVO_1034        :E::::A::VS:AAE::::::::::::::Q::::::::LG::::N:A:::::::::::::
hla2295         :::::::::VS:GKSA:::Y::::::Q::::::::::M::::::::::::::::::::::
Hbo0528         :::::::::VS:G:EQ::Q::V:::::::::::::::::G:::::::::::::::::::H

consensus       GSAFTIRKYADEPFTPIDLLEYGTFSVEQMAYLWLAIEHNKSLIFAGGTASGKTTSMNAV
#oth            .....1.3.111.1..22.1411.113111..1.11..1..112......1........2
VNG0823         :::::::::SE:::::AT:VD:D:::LD::::::::::S::::L::::::::::::::::
NP3106A         :::::V:::S::::::::::::::Y:L:::::::M::::::NIV:::::::::::::::I
Hut0470         ::::::::::ED::::::::K::::NR:ML:::::::::::::L::::::A:::::::::
rrnAC0466       :::::::::::::::::E::::::::::ML::::::::S:::::::::::A::::::::L
Hmu1138         ::::::::::::::::::::N:::::::ML::::::::S:::::::::::A:::::::::
HVO_1034        :::::::L::E::::::::VR:::::I::::::::C::::::::::::::::::::::::
hla2295         :::::::Q::ED:L:::::V::::::I:::::F::C::::::::::::::::::::::::
Hbo0528         :::::::M:::D::::V::V:F:::::::::::::C::::::::::::::::::::::::

consensus       SMFIPPRSKVLTIEDTRELSLYHDNWLSSVTRERLDEGSD-ITMYDLLRSALRHRPEYII
#oth            1..2...1.211.......1.1......11..2143214.112.......1......1.1
VNG0823         :::V:::A:I:::::::::A::::::::::::GADGG:G:T:::::::::::::::::::
NP3106A         :::::::::LI:::::::::::::::::C:::::::::A::V::::::::S:::::::::
Hut0470         :::::::A::::::::::::::::::::::::::F::-D:::S::::::::::::::::V
rrnAC0466       A::L:::::::S::::::::::::::::::::::::D-::::::::::::::::::::::
Hmu1138         :::::::::::::::::::::::::::::::::::::-::::::::::::::::::::::
HVO_1034        :::V:::::::S:::::::A:::::::::::::::H::T:::S:::::::::::::::::
hla2295         :::V:::A:I:::::::::::::::::::I::::RY::A:::D::::::::::::::::V
Hbo0528         :::::::::::S:::::::::H::::::::::N:MH::::::D::::::::::::::F::

consensus       VGEVRGEEAITLFQAMNTGHTTFSTMHADSVQTVINRLENEPINVPRAMVQSLDILCVQT
#oth            ......2..2............2.......11........1......1.1....3.21.1
VNG0823         :::::::::M::::::::::::Y:::::::::::::::::D::::::::I::::::::::
NP3106A         ::::::::::::::::::::::L::::::::::::::::::::::::P::::::V:::::
Hut0470         :::::::::::::::::::::::::::::::::::::::::::::::P::::::::A::V
rrnAC0466       :::::::::::::::::::::::::::::::::::::::::::::::P:::::::::::V
Hmu1138         :::::::::::::::::::::::::::::::::::::::::::::::P:::::::::::V
HVO_1034        ::::::D::V::::::::::::::::::::IE::::::::::::::::::::::L:::::
hla2295         ::::::A:::::::::::::::::::::::IE::::::::::::::::::::::M:SI::
Hbo0528         :::::::::V::::::::::::::::::::IE::::::::::::::::::::::L:::::

consensus       LTRSGDERVRRAKTIAEIEGIDQRTGELDYSNAFEWDAETDEFEQRDSSLLDEIREERGW
#oth            .214111....13211..11......1...23114.3234.513332131121.23.1..
VNG0823         ::HV:::::::SSV::::::::::::D::::T:::::PTR:D::::::NV::::QD::::
NP3106A         :A:F:G::::::S:::::::::::::::::T::YR:ESGS:::REGTR::M:::::::::
Hut0470         :::Q::::::::::L:::::::::::::::A::Y::QPTA:GYAE::::::ED:::::::
rrnAC0466       :A::::::::::::L::::::::::::::::TTYN:R:TE:R:SENN:E:::::::::::
Hmu1138         :G:::G::::::::L::::::::::::::::::YA:Q:DE:Y::DSN:D::::::R::::
HVO_1034        :::H:G:::::SQ::G::GD:::::::::::S::A:EP:::T:S:N:::::T::QR:N::
hla2295         ::::::Q::::::::G::G::::::::::::S:::::::::::SRN::::ME::AD::::
Hbo0528         ::::KG:::::SRA:G::G::::::::::::R::S::::::T::::N::::E::QS::::

consensus       SRSELLRELRRRERFLRYLQEEGVTDYRRFTALVNEYYADPERVMARIEAAED-------
#oth            1121.11.232.321143.3442121.13..121.2...2314.3522245635111111
VNG0823         :::D::::::N:K:V:Q::V:QD::::::::::I:::::Q::::V::VTD:L::::::::
NP3106A         :Q:::::::Q::RLV:QF:::R::NE:Q::::M::R:::S:DT::Q:::E::TD::::::
Hut0470         :QA::::::ED:::::A::L::D::::::::SF::R::::KDA:LST:::QP:TE:::::
rrnAC0466       :Q::::T:::N:Q:::::::S::I::::K:::M::K::::K:Q:I:N:DD:IA:::::::
Hmu1138         :Q::::::MDD:K:::::::A:SI::::::::M::K::::S:T::E::DR---:::::::
HVO_1034        ::T::R:::::::G:::::LDK:::::::::::I::::::S:D::R:V::D::I::::::
hla2295         ::::::::V:::::::EL:RGL::::::A::::::::::::::::D:L:ERS:G::::::
Hbo0528         T:A::R::V::::::IWS:V:L:ID:::Q:::::::::::AD:::D:L:SEV:AEIPTER

consensus       ---------------------------------SDVGDAA------------
#oth            1111111111111111111112212111111225243353333331111111
VNG0823         ::::::::::::::::::::::::::::::::::::AA::PGVVE:::::::
NP3106A         :::::::::::::::::::::::::::::::LDT:LD:KSDQQQA:::::::
Hut0470         :::::::::::::::::::::::::::::::::-------::::::::::::
rrnAC0466       :::::::::::::::::::::::::::::::::-------::::::::::::
Hmu1138         :::::::::::::::::::::::::::::::::A:IDATP::::::::::::
HVO_1034        :::::::::::::::::::::::::::::::::V:A:SE:::::::::::::
hla2295         ::::::::::::::::::::AAKPS::::::::GP:::::D:::::::::::
Hbo0528         DERDGLSVGVENEPHVESGSAEEPQTGDDSGVE:P:::DSHRSDGTGDETAR