8 genomes BUD0819 8 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1394 rrnAC0867 HVO_1667 Hbo3170 Hmu1623 Hut1097 hla2378 NP3370A -

Pairwise sequence scores
Consensus score	1225	Hut1097	VNG1394	HVO_1667	Hbo3170	hla2378	rrnAC0867	NP3370A	Hmu1623
845	Hut1097	1222	648	596	721	697	719	748	773
783	VNG1394	648	1254	666	681	712	692	662	694
796	HVO_1667	596	666	1147	766	729	749	716	714
915	Hbo3170	721	681	766	1337	844	752	780	782
911	hla2378	697	712	729	844	1567	771	798	859
927	rrnAC0867	719	692	749	752	771	1402	817	936
949	NP3370A	748	662	716	780	798	817	1223	871
982	Hmu1623	773	694	714	782	859	936	871	1635

223 symbols
consensus       ----MSTDDSDDDEGES-----GD---------------------VRERLEEEADRAVEE
#oth            1111142.333425423111214243333223322332322222332222143122.133
Hut1097         ::::-M:::NPN:G::::::::E::::::::::::::::::::::::S::::G:G:::::
VNG1394         :::::PE:SR:TNTA--:::::--:::::::::::::::::::::A::H::DGT::::AG
HVO_1667        ::::::A:Q:TEGSA:::::::T::::::::::::::::::::::-EDDSGGA::C::S:
Hbo3170         VIEH::::::S::PT::::::::SADETVADHGDESTEQ:::::TT:::::A::::::A:
hla2378         :::::T:::::::S:DDPAFDAA:GPASTADDESPTERTREELRKTK:::G:S::K::KG
rrnAC0867       ::::::A::N:H::L:D:::::T:::::::::::::::::::::D::D:I:Q:::::::Q
NP3370A         :::::A::K:S:::::::::TA::SDG::::::::::::::::::::D:::Q::E::A:Q
Hmu1623         :::::T:::TS::REDE:::::::DFGEDPFGDDPFDEELDDDVD::::::::::::::S

consensus       FDDGIVDLLAWVLDTETRARIYVHLRQNPESTSEEVAEGTGLYPSTVREALAELHDEGIV
#oth            ..1221.1.1.2...1.....1.2..23152..1.1.2...........11.2.231241
Hut1097         ::ERVI:V:S:::::::::::::Y::A:T:Q::::::D:::::::::::T:::::TD:::
VNG1394         ::::V::V:::L:::D:::::F:Y:::H:Y:::D:::D::::::::::::V:::AADS::
HVO_1667        ::::L::::::I:::::::::::::::H:H::::::::::::::::::::::::A:DET:
Hbo3170         ::ENV::::::L:::::::::F:F:::::HA::::::N:::::::::::::::::::EM:
hla2378         :::N:::::S:L:::::::::::F::D::N:::D:::D::::::::::::::::::::T:
rrnAC0867       ::E::::::::::::::::::::::::Q:::::::I::::::::::::::::A:TE:E::
NP3370A         :::::::::S:::::::::::::F:::::G:::::I::::::::::::::::G::E::RL
Hmu1623         ::E::::::S:::::::::::::::::R:D:::D:I:::::::::::::::::::E::K:

consensus       DRRKREADGAGNNPYEYEAIAPSDLVGDAVGEVQSELNTVFNLDRRLGG---DDEDDDTE
#oth            5.3..332.1.......4.12..1..6232131.32..221...4212231243625231
Hut1097         V:E:::HE:T:::::::S:::::E:::::I::I:D::::IV:::AY:S::::-:DEETS:
VNG1394         :::::H:E:::::::::T::P:::::A:T::R::RG::S:::::A:::DSDD:TASH::-
HVO_1667        E::::KSS:::::::::V::::::::KGVS:Q::AQ::A::::::H::-:::T:RS:E::
Hbo3170         S::::KNS:::::::::::::::E::RG:::Q:::Q:::L:::::::L::::::G:G:V:
hla2378         ::D::::S:::::::::::::::E::QGV::D::R:::A:::::::::::::ESP:G:::
rrnAC0867       T:Q:::S::::::::::S::S:::::NTI::DI:::::::::::DHI::E::TTLEP:N:
NP3370A         E:Q::D:::::::::::T:M:::E::::::::I:D:::::::::SH::-:::VC::::::
Hmu1623         A:Q:::S::::::::::A:M::::::T:V:D:::::::::::::NY:::RDR:T::TE::

consensus       PVTITVEDADDD--D-------------------------DD-
#oth            ..3.2.3325323433233222213322332221111113324
Hut1097         ::S:::S::TEETD:S:::::::::::::::::::::::A:SE
VNG1394         ::R:E::::SPEADTA:::::::::::::::::::::::A::T
HVO_1667        ::::::REE---::-:::::::::::::::::::::::::--:
Hbo3170         ::::::R:DT:E::-:::::::::::::::::::::::::--:
hla2378         ::Q:S:DSD:E:EKRSDEADEADDGEEDGT:::::::::KS:R
rrnAC0867       ::::S::::N::AT:ADASEATGDDGDESEDGND:::::DA:V
NP3370A         :::::::RD:P-::-:::::::::::::::::::::::::--:
Hmu1623         ::::S:S:EA::EA:DETDDETDDETDDEATDSDDDAAAD::E