[V] (CcmA) COG1131 ABC-type multidrug transport system, ATPase component 8 genomes BUD0829 8 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0689 rrnAC0479 HVO_1443 Hbo0113 Hmu1152 Hut0635 hla1833 NP2802A -

Pairwise sequence scores
Consensus score	2229	NP2802A	Hut0635	rrnAC0479	Hmu1152	HVO_1443	Hbo0113	VNG0689	hla1833
1769	NP2802A	2315	1584	1555	1592	1413	1508	1333	1475
1789	Hut0635	1584	2283	1670	1678	1454	1454	1410	1469
1811	rrnAC0479	1555	1670	2231	1843	1496	1466	1327	1430
1803	Hmu1152	1592	1678	1843	2230	1380	1454	1355	1475
1657	HVO_1443	1413	1454	1496	1380	2461	1661	1350	1465
1730	Hbo0113	1508	1454	1466	1454	1661	2487	1337	1582
1532	VNG0689	1333	1410	1327	1355	1350	1337	2148	1453
1769	hla1833	1475	1469	1430	1475	1465	1582	1453	2466

348 symbols
consensus       MIEVRDLRKEYGDFAAVEGSTFSVDRGEVFGIIGPNGAGKTTTLKMLAGLLEPTSGDVEI
#oth            ..412311.2..113..3112.2.33..1..21........1...212..21.14.3251
NP2802A         ::::::::::::G::::::::::::S:::::V:::::::::::::AI:::::::::T:A:
Hut0635         ::::::::::::G:::::::::::::::::::::::::::::::::::::I:::A:::Q:
rrnAC0479       ::DA::I:::::G:V::Q::S:::::::::::::::::::::::::::::::::::SA::
Hmu1152         :::A::::::::::V::::::::::::::::V:::::::::::::::S::::::::::SV
HVO_1443        ::T:EN:::T::::P::V::D:::ES::::::V:::::::::::::::::V:::G:SASV
Hbo0113         ::R:EG:::T::::P::V::D:E:EE::I::VV::::::::::::::S::I:::E:TAR:
VNG0689         ::S:QR:E:R::GVT::D:VS:D:GA:::::LV::::::::S:::::C::V::SA::ITV
hla1833         ::::EG:::T:::::::VD:::::AE::::::V::::::::::::V::::VD:SD:E::V

consensus       AGYDADDPEMRRQLGFLPEESPLYEEMTPRSYLRFFADLYDVPRDVANERIEDTLDRLEL
#oth            3132433411.14...........11.112...3........1343.43.2222..1.2.
NP2802A         N:EP::SR:T::R::::::::::::::S::::::::::::::::E:::Q:::N:::::::
Hut0635         ::LA:::SA:::R::::::::::::::::I:::T:::::::::ENQ:IT::H::::::D:
rrnAC0479       ::L:TETA:::Q:::::::::::::::::I:::K::::::::DP:::E::MH::::E:::
Hmu1152         ::::VT:T:::Q:::::::::::::::::L:::::::::::::T:::T::MH::::E:::
HVO_1443        L:::PEE:A:::K::::::::::::D::A::::::::::::::::::D::TGAV::::G:
Hbo0113         GE:::G::::::H::::::::::::D::A::::H::::::::::EA:TR:T:::::::::
VNG0689         N:F::G:TA:::T:::::::::::D:::::::::::::::::D:AT::::::AA::::D:
hla1833         ::FAS::::::::::::::::::::::::L::::::::::::::KA::::::AA::::::

consensus       EHRDRRLGDMSKGMKRKVAIARSLVNDPDVLVYDEPASGLDPLTTNYVIEFTRELAEEGK
#oth            32.1.31..1....1.........1....1.1..........1...4112.132.15411
NP2802A         A::E:A:::::::::::::::::::::::::::::::::::::::::I::::K::::::R
Hut0635         Q::::P::::::::::::::::::I:::::::::::::::::::::FI:D::T::::A::
rrnAC0479       :::::K::::::::::::::::::I::::::I::::::::::::::::::::EQ::K:::
Hmu1152         :::E:K::::::::::::::::::I::::::::::::::::::::::::Q::EQ::R:::
HVO_1443        :Y:::::::::::::::::::::::::::L:I::::::::::::::V:L::V:::RD:D:
Hbo0113         :::::::::::::::::::::::::::::L:I::::::::::::::::L::::D:::R::
VNG0689         DA:::PV::F::::T:::::::::::::::::::::::::::::::T:::::::::AD::
hla1833         D::E::::::::::::::::::::::::::::::::::::::V:::S:L::::::RST::

consensus       TIVFSAHNLYHVESICDRVAIMNEGEIVARGTLEEIREEHGETTYHVFTTV---------
#oth            .1.....1.2...21....11.23.41212.314411231.223.1.1.12111111111
NP2802A         :V:::::::::::EV::::::::::K::TK:P:S:L::TY:::E::::::::::::::::
Hut0635         :::::::::::::::::::::::Q:S:::::P::TL:::::::::::Y::I:::::::::
rrnAC0479       :::::::::F:::::::::V:::::::::::D:::LQA:Y:H:R:::Y::::::::::::
Hmu1152         :::::::::::::T:::::::::::Q:::::D::ALQD:Y:DRE:::Y::::::::::::
HVO_1443        :V:::::::F:::::::::V:::R:::I::::VP:::A:::::::R::::::::::::::
Hbo0113         :V::::::::::::V::::V:::R:::I::::VP::::Q::::S::::::T:::::::::
VNG0689         :::::::D:H::::V:::::::RD:QFA:T:::AD::D::::VS:R:::D::::::::::
hla1833         :V::::::::::::V:::::V:D::R:::::SVDG:::R::::::R:::D:SPARTDALA

consensus       ----DVPDAVEENG--RYRRVVDSMDAVEAVREAAAAAGGEVVDIRTEEPSLEDVFLDVA
#oth            222232232445211323222.33133.223.14.2221.312....4.21..22..222
NP2802A         ::::E::GS::DDD:::::::::DI::::::::::VER::RLA::::V:::::GL:::::
Hut0635         ::::EL:GSEQQ::::::V:S:N::GE:::T::D::ER:::::::::::A:::E:::N::
rrnAC0479       ::::::::::Q:::::S:K:::E:::::::T::Q:E:N::D::::::::S:::E:::N::
Hmu1152         ::::E::G::A:::::NW::::ET::G::D::A:::ER::::I::::::S:::E:::N::
HVO_1443        PLAETL::DD:ID:EE:HVA:::E:S:::SL::R:E::::R:A::::D:A::::I::RL:
Hbo0113         ::::A:EN:ETTDD:G::::::PD:::::S:::E:E::D::::::::H::::::I:::L:
VNG0689         ::::::D::RPS::::::VTT::::AD:D:I:A:::D:::G::::::D:ST::::::::T
hla1833         DIFD:IDA:I::V::D:F:TT:PT::::A::::::::::::::::::R::::::::::IV

consensus       --------AAGGRGTA------SVAEGE--------------------
#oth            243243345743444311111134436543333443434111111111
NP2802A         :::::::SGRNE:NDR:::::::A::HSQQTTADRPTEG:::::::::
Hut0635         :DEPAQAA:T:TT::G::::::T:DP::::::::::::::::::::::
rrnAC0479       ::::::::E::T:::R::::::Y:E:DAE:::::::::::::::::::
Hmu1152         ::::::::ESETP::R::::::Y:E:A-::::::::::::::::::::
HVO_1443        REAPTTSE:E::::Q:ADGEREYADDEREQRVAGGRGQS:::::::::
Hbo0113         GRPPETRADDR::AA::::::::QTD:GRSATGPERDQQEEDRIGGTQ
VNG0689         GA::::::--------::::::------::::::::::::::::::::
hla1833         GRPMPGRYTG::GDA::::::::T::T:TDRLTESEEAE:::::::::