[R] (-) COG1418 Predicted HD superfamily hydrolase 8 genomes BUD0930 8 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0534 rrnAC1822 HVO_0867 Hbo0671 Hmu0781 Hut1035 - NP1636A HQ1712A

Pairwise sequence scores
Consensus score	1744	VNG0534	HQ1712A	HVO_0867	Hbo0671	NP1636A	Hut1035	rrnAC1822	Hmu0781
1254	VNG0534	1596	1055	1167	1172	1108	1114	1153	1131
1301	HQ1712A	1055	2173	1308	1300	1184	1130	1148	1165
1497	HVO_0867	1167	1308	1762	1473	1293	1299	1224	1338
1467	Hbo0671	1172	1300	1473	1733	1335	1282	1206	1297
1460	NP1636A	1108	1184	1293	1335	1760	1283	1265	1338
1438	Hut1035	1114	1130	1299	1282	1283	1714	1251	1365
1396	rrnAC1822	1153	1148	1224	1206	1265	1251	1680	1411
1501	Hmu0781	1131	1165	1338	1297	1338	1365	1411	1815

286 symbols
consensus       VGVEIRESPVSDAEFEEMKRFVHDYLAASVENEDDGGRMRWYPWHSAEYRFNHILNVVDL
#oth            21121212221231115.34..4...2....2132................1..2..211
VNG0534         -----------------:AA::R:::E::::::T:::::::::::::::::T::M::::I
HQ1712A         M::K:K::AI::T:::R:QQ::Y::::::::GDE::::::::::::::::::::Q::IEI
HVO_0867        :::::K::A:::::::D:::::S:::S:::::::::::::::::::::::::::::::::
Hbo0671         :::::K:::::AE:::T:Q:::K:::::::::::::::::::::::::::::::::::::
NP1636A         M:::::::::::E:::::::::R::::::::S::E::::::::::::::::::::::TE:
Hut1035         :::::::A:::A::::::::::::::E::::::QA:::::::::::::::::::::::E:
rrnAC1822       -----------------::E:::::::::::::EE::::::::::::::::::::::::I
Hmu0781         ::::::::::::::::A:RD:::::::::::::EE:::::::::::::::::::::::::

consensus       ATRIARREGANVDVTRVAALFHDIAKLEAEQDVHAEEGARIAREYLRTHGDYPQSFIDQV
#oth            .35..4411.212.1..1.....11....2.13..12..111111.422322.3..111.
VNG0534         :E:::EATS:::::V:::::::::::::::::A::::::::::K::E:::QF:P::V:::
HQ1712A         ::T::D::::AI::V::S::::::S::::N:E::::::::VT::::Q:CDNL::::::E:
HVO_0867        :::::D::::D:N:V:::::::::S::::D:E::::::::V:::F:SS:::::D::V:::
Hbo0671         :SN::E::::D:::V::::::::::::::::E::::::::V:::::S::::F:::::E::
NP1636A         :SK::AE:::::::::::::::::::::::::::::A:::V::::::SRT:::E::::::
Hut1035         ::D::KQ:::D:Q::::::::::V::::::::E::AA:::::K:F:E::S::::::VE::
rrnAC1822       ::K:::K:::::::::::::::::::::::::L:::A::::::::::A:::::E:::E::
Hmu0781         :VE:::E:::::::::::::::::::::::::::::V::T::::::LS:::::D::VE::

consensus       CQAVADHSYQGDLTDLPLETRCLIEADILDKVGANGTALMLLRMGYEARTHMDAAEMVER
#oth            232133...112.3132..211.2...2...2....12.2.......1.1.2..3..13.
VNG0534         AE::SR:::::::M:::::A:::V:::L:::A::::A::::::::::::::V:::::IQ:
HQ1712A         ::S::E:::::P:S:TS:::QS:::::::::I:::::V:I:::::::S:::T::::::D:
HVO_0867        ::V:S::::::P:::VS::::::::::::::I::::::::::::::::::::::::::::
Hbo0671         ::V::::::::P:S:VT::::::::::::::::::::V::::::::::::::::S:::::
NP1636A         :A:::::::E:::DTM::::Q::M:::L:::::::::M::::::::::::::::N:::G:
Hut1035         VA:IE::::::::::::::::::::::V:::::::::::L:::::::S:S:V::P:::::
rrnAC1822       :S::EV:::::S:D:::::VQ::::::::::::::::::::::::::S::::::::::D:
Hmu0781         :S::R:::::D:::::::::Q::::::V:::::::::::::::::::S:S::::::::G:

consensus       VLERGEDARERVESDTAESIAHQRLKRVRWFREWLEEEVAEMDDEDQV------------
#oth            .31..22.53.23112.213211.1..21.131..13.1131362466643322322131
VNG0534         ::D:::::A::::::A:S::::R:::::::LHD::TS::PA:N:TGY-::::::::::::
HQ1712A         :::::RN:K:::V::::::::Y::::::K:::::::S::PA:STDANIEFTPDPTKADAH
HVO_0867        :F:::R::SD:L:T:::Q:F::::::::K::::::::::P:::HDG:FSG::::::::::
Hbo0671         :::::RA:TD:I::ES::::::::::::K::::::::::PG::R:EFGV:::::::::::
NP1636A         ::::::::IA::R::::Q::::::I::::::K::::G:::G::P::GAAAEL::::::::
Hut1035         :T:::T:::::I:::::::YL:R::::::::K::::::I:VV:A:SE:::::::::::::
rrnAC1822       :I::::::::::Q::::::LV::::::T:::Q:::TM:::::AV::DLDDVATGM:GDS:
Hmu0781         :I:::::::Q:I::E:::A:V:R::::AK::Q::::M:::::::DS::GDVATGVGGDD:

consensus       ----------------------------------------------
#oth            1111111111111111111111111111111111111111111111
VNG0534         ::::::::::::::::::::::::::::::::::::::::::::::
HQ1712A         TTHGDIDSNISVATGTDTDSTDTNTDTDTNPDTNNTNPVDTHISDR
HVO_0867        ::::::::::::::::::::::::::::::::::::::::::::::
Hbo0671         ::::::::::::::::::::::::::::::::::::::::::::::
NP1636A         ::::::::::::::::::::::::::::::::::::::::::::::
Hut1035         ::::::::::::::::::::::::::::::::::::::::::::::
rrnAC1822       ::::::::::::::::::::::::::::::::::::::::::::::
Hmu0781         ::::::::::::::::::::::::::::::::::::::::::::::