[H] (CobH) COG2082 Precorrin isomerase 8 genomes BUD0978 8 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1567 rrnAC3020 HVO_B0049 Hbo1614 Hmu2007 - hla2078 NP1090A HQ2297A

Pairwise sequence scores
Consensus score	1676	HVO_B0049	Hbo1614	HQ2297A	NP1090A	hla2078	Hmu2007	VNG1567	rrnAC3020
1367	HVO_B0049	1673	1542	1284	1266	1295	1278	1346	1309
1373	Hbo1614	1542	1672	1314	1257	1294	1278	1340	1329
1468	HQ2297A	1284	1314	1911	1397	1378	1389	1398	1419
1509	NP1090A	1266	1257	1397	1697	1476	1490	1411	1443
1541	hla2078	1295	1294	1378	1476	1764	1538	1439	1488
1566	Hmu2007	1278	1278	1389	1490	1538	2073	1460	1506
1535	VNG1567	1346	1340	1398	1411	1439	1460	1742	1485
1566	rrnAC3020	1309	1329	1419	1443	1488	1506	1485	1778

281 symbols
consensus       MTTD-------------------D-FEEYADLGATTENAMDIAETSMDRVRELVPDETLA
#oth            ..14112222232333444345436213........23.11..11...1.122.11...2
HVO_B0049       ::ER:::::::::::::::::::-:-DA::::::::QE::::::::::I::TF::::::N
Hbo1614         ::EK:::::::::::::::::::-:-:D::::::::QE::E:::::::I::TF::::::N
HQ2297A         :::E::KNAHMDLSTDGGSGSTN:EY::::::::::SD::E:::S::::::::::::::E
NP1090A         :::::::::::::::::::::::ET:::::::::::SE::::::::::::HD:::Q::::
hla2078         :::::::::::::::EPRPDDADES:D::::::::::::::::T::::::::::::::::
Hmu2007         ::::GATPEESRDEGDPAADEER:A:::::::::::::::E:::::::::::I:::::::
VNG1567         :::::::::::::::TTPDGDDEQD::S:::::::::K:L::::::::::::::::::::
rrnAC3020       :::N:::::::TDDATDGDANSD:G:::::::::::S:::::::::::::::::R:::::

consensus       DRLRQKSVHATGDPEFQHLVRFTG-D-SEPVRAGARAVLDERPIVTDITMVKAGITGRGH
#oth            ..3.1.1..1...1.....3.13121232.112..1...2.2.1......1.1.1.....
HVO_B0049       ::::::A::S:::I:::::I:CQN:-:-D::V:::::::::::V::::::A:::::::::
Hbo1614         ::::::A::S:::I:::::I:CQN:-:-N:AV:::::::::Q::::::::A:::::::::
HQ2297A         ::::::A:::::::::::::::A::-:-D:::T::::::S:Q::::::::::::::::::
NP1090A         ::M:A::::::::::::::M::::T:E:::::N:::::::::::::::::::E:::::::
hla2078         ::V:::::::::::::::::::::T:D::::::::::::E::::::::::::E:::::::
Hmu2007         ::I::::::::::::::::M::::T:D:::::::::::::::::::::::::E:::::::
VNG1567         :::::::::::::::::::L::N::-:G:::::::::::::A::::::::::::V:::::
rrnAC3020       ::I:::::::::::::::::::::A:DD:::::::Q:::::Q::::::::::::::::::

consensus       DCPVRKAIGNGAELAAETGMTRTAASVLELDKQGVYDDAIAVVGNAPTAALALADCIEDG
#oth            2.2.3......1.............1.....22...11..111.....1....1...14.
HVO_B0049       ::Q::::::::::::::::::::::A::::::E::::G:::::::::::::::C::::N:
Hbo1614         ::::K::::::::::::::::::::::::::::::::G::::::::::G:::::::::::
HQ2297A         Q:::K::::::S:::::::::::::::::::R:::::::::TI:::::::::::::::S:
NP1090A         N::::::::::::::::::::::::::::::SD::::::::TI:::::::::::::::Q:
hla2078         ::::G::::::::::::::::::::::::::RD::::::::::::::::::::::::AE:
Hmu2007         :::::::::::::::::::::::::::::::SE:::E:::T:::::::::::::::::::
VNG1567         ::E::::::::::::::::::::::::::::::::::G:::::::::::::::::::A::
rrnAC3020       ::::Q::::::::::::::::::::::::::::::::G::::::::::::::::::::::

consensus       TRPAVVVATPVGFVKAAESRKRLREVAAEHGVPAITNVGRRGGSGLAAGLTNELVHVASD
#oth            ....12.......1..1...3.2.2113.111.11.1..1........1.1...1.....
HVO_B0049       ::::A:::::::::::E:::::V:D::D:Y::::V::::K::::::::A:::::I:::::
Hbo1614         ::::AI::::::::::E:::::V:DI:D:YDI::V::::K::::::::A:::::I:::::
HQ2297A         ::::AI:::::::I::::::N:I:A::T:Y::::::T:::::::::::::::::::::::
NP1090A         ::::::::::::::::::::::::A:C::::::TV:::::::::::::::::::I:::::
hla2078         ::::::::::::::::::::E::::::R::D:::::::::::::::::::A:::::::::
Hmu2007         ::::::::::::::::::::T::::::::::::T::::::::::::::::A:::::::::
VNG1567         :::::A::::::::::::::T::::::::Y::::V:::::::::::::::::::::::::
rrnAC3020       ::::::::::::::::::::E::::::::::::T::::::::::::::::::::::::::

consensus       VRDGDVDLE--------------------------------
#oth            1.3.3131453222222222222221111111111111111
HVO_B0049       ::N:::::ANHE:::::::::::::::::::::::::::::
Hbo1614         ::::::::SDHE:::::::::::::::::::::::::::::
HQ2297A         ::::K:T::TAPTEANRHDHREVER::::::::::::::::
NP1090A         A:::E:E:-::::::::::::::::::::::::::::::::
hla2078         A:N:E:::S::::::::::::::::::::::::::::::::
Hmu2007         ::A:ELSI:SSPAGRPSGERSDPRGGASESAERSSGESDGE
VNG1567         ::::::S:TES::::::::::::::::::::::::::::::
rrnAC3020       ::E:V:::-::::::::::::::::::::::::::::::::