[MR] (-) COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily 8 genomes BUD0979 8 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1837 rrnAC3455 HVO_2638 Hbo2204 Hmu2493 - hla1635 NP2480A HQ2035A

Pairwise sequence scores
Consensus score	2586	HQ2035A	NP2480A	VNG1837	hla1635	HVO_2638	Hbo2204	Hmu2493	rrnAC3455
1422	HQ2035A	2576	1035	1187	1247	1262	1251	1145	1149
1750	NP2480A	1035	2563	1422	1598	1467	1530	1330	1315
1899	VNG1837	1187	1422	2600	1695	1639	1691	1306	1340
2070	hla1635	1247	1598	1695	2608	1808	1913	1340	1383
2083	HVO_2638	1262	1467	1639	1808	2583	1966	1320	1361
2058	Hbo2204	1251	1530	1691	1913	1966	2594	1305	1369
1612	Hmu2493	1145	1330	1306	1340	1320	1305	2604	1546
1664	rrnAC3455	1149	1315	1340	1383	1361	1369	1546	2613

352 symbols
consensus       --MNTEFERVSLPLEDPFTIARGTQTTAENVIVRITDE-GMTGVGAAAPSAHYGETADTV
#oth            23253323233322442.2.2.11334223331425124.31.2.111.231.1.1.211
HQ2035A         :::K:S:NQI::NIT:S:N:::::TERV:ITLI::Q::N:HI:I:G:T:T:Y:::::A:M
NP2480A         :::KASI:::E::::T::::S:::KR:V::L::V:KHN::S::Y:::::ARY::::::::
VNG1837         :::::D:::RQF:::H:::::::::D::TV:T:SVS:DD:T::::::::::::::::A::
hla1635         MTLE:::::::::::N::::F:::::D::::::K:A::A::::::G::::::::::::::
HVO_2638        :MLA::::L::MS:AE::G::::V::E::::V:::E::G:::::::::::S:::::::::
Hbo2204         VLLT:::::::Y::A:A:::S:::::A:::::::V::DG:::::::::::::::::::::
Hmu2493         ::VRFS:Q:HE::TD:::G:::::T:::AV:T:E::H:::T::::G::::EY:::::AS:
rrnAC3455       ::::WTVD:HD:::SN::G:S:E:SE:S:TAT:EL:H:::T::I::VT:::Y:D:S:QS:

consensus       EAVLPDLLDVVESVGDPHALQRIERRLAEVVRDNPAARAAVSIALHDLAAKRLGVPLYRL
#oth            324.1312531133122124531245124424221..12.111.22.11213114.2122
HQ2035A         R:I::EF:EII::H:-MEPRHA::Q::YNH::G:::::::::T::A:I:G::ADM:::E:
NP2480A         A:L::E:::A:::I:::::RNQVHE:M:T:AG:::::K:::DT::W:::G:L::E:V:::
VNG1837         D:::::::A:::R:DA:EH:A:::AG:RD::SG:::::::::::C:::V:::ADC:::QY
hla1635         :::::::::A::R:::::::HE::AE::A::NG:::::::::::V::::::::::::H::
HVO_2638        ::::::::S:::A:::A::ID::::EM::T::R:::::T:::::::::::::::::::::
Hbo2204         :::::E::T:::::::::::TE:::KMR:R:GR:::::T::::::::::S::::L::::Q
Hmu2493         RDA:EA:RP:::AWD::::G::VANA::TRLP:AA:::::::T::A::::RD::::C::Q
rrnAC3455       AQT::L:CET:DGI:::::Q:::::D:::QAP:Q::::M:L:::V:::::RQ:DL::::Q

consensus       WGLDPAAT-PPTSYTIGLDDPETMREKAEAAVDAGYGVLKVKLGTDRDRA--RIRAVRDA
#oth            1..11344115111.121133221211145.232.123..2.1.232115112242..33
HQ2035A         :::::TDI::K:::::S::T:RA:QA:::T::NN:FDI::L:::H:NE:NHK::A:::Q:
NP2480A         L::SAS:SC::::::V::::::::A:R:K:::::::P:::L:::SE:::D::IV:S::EI
VNG1837         ::::::N::VE::::::I::A::::::TR::::::F:T:::::::P::EQ:::LS:::E:
hla1635         :::::T:A::A::::::::ET:RV::::::::::::PI::I::::::::E::L:D:::E:
HVO_2638        :::::SR:::TS:::V::::LD:::::TAE:YE:::::::::::::::::::I:E::::E
Hbo2204         ::::ADE::::::F:::::ET::::::T:D::E:::P:::I:::::::EE::IVET::::
Hmu2493         :::::::A::R::::VAIA:::::A:R::R::A:::DT::::V:::D::S::::::::RG
rrnAC3455       :::::D:V::::T::V:IAS::R:A:::GK:A:S:F:H:::::::GD::::::LD:::::

consensus       APDATIRVDANEAWTPREAVRNAEWLADYGVEFVEQPVPADDPEGLRFVYERSALPIAAD
#oth            1.2131.1...2.11232.124435..2311212....2.5242.131.433332.11..
HQ2035A         T:::Q::A:::A:L:SQQ::EISDI::N:DI::L::::::N:ID::Q::QAYGSV:V:::
NP2480A         ::E:::::::::::::SA::::CKA:::::::::::::A:GNA::::R:::Q:P::::::
VNG1837         ::::::::::::::::::::::I:R::::::::::::::::H:A::Q::H::A:::::::
hla1635         ::::RL:::::::::::::::KC:::::RD::::::::::E:::::::::::::::V:::
HVO_2638        ::GV::::::::::::::::EMT:F:::H:::::::::::E:H:::K:::D:G:::::::
Hbo2204         :::::::::::::::::::::KS:M::::::::I::::::S::::VQ:::::::::V:::
Hmu2493         :::::L:::::C::S:A::IEQ:G:::ERD:Q:L::::A:::LD::ER:ASATS:::C::
rrnAC3455       ::::EL:::::A:::AQ::ID::D::::A::TML::::E:H:ID:::R:TDATEI:V:::

consensus       ESCVTAADIPRVADACDIVNLKLMKCGGLREAKRAIHAARAHGLDVMLGCMIESNASIAA
#oth            ..12213.11221.32.1222..1.1.11221414232.3.11112.1...2.1.11..1
HQ2035A         ::VI::::VS::S::V::IVA::::::T:::VR:IAAV:D:VNCES:::::V:::V::::
NP2480A         ::::V:G:::A:::S::::::::::T:::TP:VE::YT:::::::::C:::V:T::::::
VNG1837         :::MV:S:::QL::K::::T:::::T::::A:M:L::T:T:::::::C::::::::::::
hla1635         :::::LS:::AI::R:::A::::::T:::L::::M:A:::::::E::C::::::::::::
HVO_2638        :::I:::::::I::RV::A::::::::::T::::::::::::::E:::::::::::A:::
Hbo2204         :::::L::V:::::RT:::::::::::::T::::M::T::::::E:::::::::::A:::
Hmu2493         ::::A:P:V::::::::L:TV:::::::V:P:VEQ::::H:::::::::::L:::::::P
rrnAC3455       ::::::S:V:::::::::::A::V::::::P:T:LLN::D:::::L:::::V::::::::

consensus       AAHLAPLLDYADLDGSLLLAEDPYDGVPMDGGEIDLGALDRAGTGARRR---
#oth            132.1..22.1....11..34.223.123443422.523424..11335422
HQ2035A         :WN::::F::V::::::::S:::IG:I::::NAAN:S::::S::C:VDTVE:
NP2480A         ::Q:L:::S::::::::::DS:::E::SVSD:RF::::V:-C:::VAP::::
VNG1837         ::::::::::::::::::::D:DF:::::PA:H:::A:I:GP:::::E-:::
hla1635         ::Q:::::::::::::::::::Q:::IE:G::::R::DQE:::::::PSAEQ
HVO_2638        GC::::::::::::::::::D:::E::::PN:::::D::::P::::Q:::::
Hbo2204         :C:::::::::::::A:::G::D:::::IKE:::R:HD:N:S::::::TE::
Hmu2493         :W:::::VE::::::AA::SR:::A::SL::RRA:::SIT:-::::::C:::
rrnAC3455       :V:::::V::V::::A::::A::::::SL::DVF::T:VS-::::V::MRDA