[K] (SUA7) COG1405 Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB 8 genomes BUD0998 8 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG2184 rrnAC2769 HVO_0226 Hbo1351 Hmu2820 - hla0446 NP5096A HQ3654A

Pairwise sequence scores
Consensus score	2165	VNG2184	NP5096A	Hmu2820	rrnAC2769	hla0446	HQ3654A	HVO_0226	Hbo1351
1508	VNG2184	2210	1365	1323	1355	1229	1312	1287	1304
1604	NP5096A	1365	2166	1378	1400	1350	1342	1348	1435
1589	Hmu2820	1323	1378	2136	1500	1321	1322	1324	1369
1681	rrnAC2769	1355	1400	1500	2149	1386	1418	1468	1453
1672	hla0446	1229	1350	1321	1386	2498	1546	1595	1625
1698	HQ3654A	1312	1342	1322	1418	1546	2378	1634	1616
1759	HVO_0226	1287	1348	1324	1468	1595	1634	2213	1748
1777	Hbo1351	1304	1435	1369	1453	1625	1616	1748	2239

337 symbols
consensus       MSEA-------------------------------------------PQRCPECDGRLRA
#oth            12422233221212212122221111111111111111111111344455....2.4456
VNG2184         ----::::::::::::::::::::::::::::::::::::::::MQH:H:::::::TI:E
NP5096A         :YT:::::::::::::::::::::::::::::::::::::::::::TRKA:::::::::S
Hmu2820         ::QT:::::::::::::::::::::::::::::::::::::::::::A::::::::AID:
rrnAC2769       ::TT:::::::::::::::::::::::::::::::::::::::::::VTQ::::N:SVKQ
hla0446         ::::RSTQTRSPRTETDDVATADRTATTDRAATADADETADADETAARET::::G::T:V
HQ3654A         ::D:PVIKTESKRKSTADISLT::::::::::::::::::::::TDT:VS::::G:HPEN
HVO_0226        ::::RS:::::::::::::::::::::::::::::::::::::::::::G::::::H:GF
Hbo1351         ::::RSPDD:::::::::::::::::::::::::::::::::::ATLTTT::::::::H:

consensus       TATETVCGDCGLVVSEDRIDHGPEWRSFADD-DTNPARTGAPLTRSRHDRGLSTEIGRST
#oth            426.41.33....152251.2.....1.3..133322.1.....1.........1..1.2
VNG2184         :D::H::A::::::TDAP::::::::T:S::P:HA:E::::::::::::::::::::Y:A
NP5096A         :D:::::DE:::::A::EL:R:::::::S:::E:::E:C:::::::::::::::::::::
Hmu2820         S:R:A::TQ:::::D::QL:R:::::::E:::GEQK::::::::::::::::::::::::
rrnAC2769       QGV:S:::S:::::G::A::P:::::::E:::::DR::::::::::::::::::K:::::
hla0446         D:A:R::T::::::EA::::::::::::D:::::::K:::::::::::::::::::::::
HQ3654A         :GE::I:::::::L::Y:::::::::::::::T:::K::::::::::::::::::::::I
HVO_0226        E:G::::T::::::::Y::::::::::::::::R::::::::::::::::::::::::::
Hbo1351         EGQ:::::::::::::YT:::::::::::::::R::K:::::::Q:::::::::::::::

consensus       RLKGRKRRQFARLRRQHNRAQISSKRERNQVYAFTEIRRLTGALSLPDAIRDRACSLFES
#oth            121.....23..1.21.2..2221.111.232111.1..22142412562114..2..3.
VNG2184         ::T:::::K::::::::K::T:P::ADY:RI:G:::::::I:TFGIGTGL::Q::T::A:
NP5096A         ::::::::RV::M::::::::V::::::::MHG:I:V:::I:Q:G::E:LQE:::V::::
Hmu2820         :::::::::M:::::E:S:::TG:::D:::RIG:I:::::VSR:D:SST::::::V::::
rrnAC2769       :::::::::::::::E:::::::::::::K:::::::::IISSMA:S::::::::V::::
hla0446         KV::::::RL::M:T::::::::T::D::K:::Y::::::::::E:::SV::T::T::A:
HQ3654A         ::T:::::::::::::::::R::T:::::::::::::::::::::::KQ:::D:::::R:
HVO_0226        :I::::::::::M:::::::R::T:::::::::::::::V:S:::::NH:::Q:::::::
Hbo1351         :V::::::RL::M:K:::::R::T:::::::::::::::::S:::::ER:::H:::::K:

consensus       AQNEDLLRGRSLEGFAAACVYAACRTAGVARTVDEICAAAKATEAELRAAYDALNRELGL
#oth            ..412..3..21......21.12..13412.122.232413.143.232.12.2..1..1
VNG2184         ::TAG::H::TI::::::G:::T:::N::T::L:::A:::R::RP::TT::::M::D:::
NP5096A         :::::::Q::CI::::::A::VV::::S:S::L:::V:::S::RD::TV::::::::::I
Hmu2820         ::EA:::V:::I::::::A:::T:::SEI::::E:VA:D:Q:STG:::V::::I::::::
rrnAC2769       :::::::Q::T:::::::AI::T:::E::::::::L:TV::::Q::::::::::::::::
hla0446         ::D:S::::::::::::::::V:::::D:::::G::::E:::::::H:::F::M::::::
HQ3654A         ::S::::::::::::::::::::::V::::::IE::TDI::::S::Q::::T::::::::
HVO_0226        :::::::::::::::::::::::::V:::S:S:E:V:DVS::::::HQ:::G::::D:::
Hbo1351         :::::::::::::::::::::::::V:N:S:::G:VV:E:::::::QS::::::::D:::

consensus       PTGPIDPREYLPRFASELDLPSDVERRARELAAEAAERGLVAGRNPSGVAAACLYTAARE
#oth            .21.32.31.11.1.24.322442112.42124525341144.11.4....1......41
VNG2184         :::::::::::::Y:DA:S::ARI::Q::::V:ALETD:::::::::::::G::::::T:
NP5096A         :::::A:T:::A::::K:G:::A:::T:::::TD:E:S::AV::D:::::::::::::E:
Hmu2820         :::::::::::::::::::V:HEI::::TA::DL::::N:I::K::G:::::::::::::
rrnAC2769       ::::::::::V::::TT::::TA:RQ::EQ:VD::QD::::S::::A:::::::::::Q:
hla0446         :IA:TG:A:::::::::::CDA::::::G:::KR:V:E:ISN::::V:::::::::::::
HQ3654A         :I:::::AQ:::::::::E:::NI::::C:YISMITAQ:IG::::::::::::::::::D
HVO_0226        :VA:A::T:::::::TK:::D::T::::::YV:::RDE:::G:K::C:::::::::::SD
Hbo1351         :V::V::V::V:::::R:::SR::::::::Y::::::Q::SV:::::::::G:::::::D

consensus       LDHELTQAEAADVADVTPVTLRATYVALRD-------
#oth            61522..34.122.1.11..1.4..33.214211111
VNG2184         T::AV::SA::A:::::::::::::QN:T:A::::::
NP5096A         H::DV:::::G:::G:SA::V:S::HD::::::::::
Hmu2820         A:Y:::::R::A::::S:::::S::Q::Q::::::::
rrnAC2769       Q:VA::::K::ET:::::::::G::TE:QE:::::::
hla0446         :GA:C::Q::::::::::::V:R:::D:TEE::::::
HQ3654A         IGF::::QT:::I::::::::::::HD::EVTLPATE
HVO_0226        RGEDC:::::::::::::::::K::::::E:::::::
Hbo1351         ::V:V::T::::::::::::::K:::::::DE:::::