[E] (GloA) COG0346 Lactoylglutathione lyase and related lyases 8 genomes BUD1004 8 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0478 rrnAC0635 HVO_1376 Hbo0177 Hmu0975 - hla2320 NP1228A HQ2401A

Pairwise sequence scores
Consensus score	986	HQ2401A	NP1228A	VNG0478	rrnAC0635	HVO_1376	Hbo0177	Hmu0975	hla2320
615	HQ2401A	985	553	560	579	591	561	580	596
693	NP1228A	553	982	575	645	638	651	651	634
734	VNG0478	560	575	1060	640	674	667	660	662
814	rrnAC0635	579	645	640	1005	708	710	704	719
846	HVO_1376	591	638	674	708	969	781	713	720
818	Hbo0177	561	651	667	710	781	982	719	703
811	Hmu0975	580	651	660	704	713	719	993	760
806	hla2320	596	634	662	719	720	703	760	984

139 symbols
consensus       ---------MHFDHVGIATDDAAGLAALFAELFDAPVAHEETFDGLSVVFLEL-DNGYFE
#oth            111111111.42..2.1..4..23.1311532122211.2.3.111623..112321.2.
HQ2401A         ::::::::::AL:::::::E::::::ER:GAV:ETQI::S:::::MYII::DM:NGT:L:
NP1228A         ::::::::::R:::A:V:::::E:::F:YED::GCSI::::R:GE:K:L:::::E:::::
VNG0478         MSARGPPAS::V::::V::E:::D:GE:YTA:LG:::::::V::::HT:::D:GGD::V:
rrnAC0635       ::::::::::Q:::A::::::::P::E::::A:ET::V:D::::::Q:T:::M:::::::
HVO_1376        :::::::::::::::::::P:::::::::::::::::::::::::M::::::::E:::::
Hbo0177         ::::::::::E:::L:V::A::T::::::T:::::::::::E:::MT:L:::::ED::::
Hmu0975         ::::::::::::::A::::::::T::::YRD:L:::I::::R::::D::::::::G::::
hla2320         ::::::::::R:::::V::R:::D::D::DG:L::::::::::::M:::::::D:G::::

consensus       LLEPH-DADGAIARYLDRRGPGIHHVALATDDIEAALETARDAGVDLIDEEPRPGAWGHD
#oth            ....43132121341.36412.1..2.33.2..23..331333.1121.12..2.....2
HQ2401A         ::::VD:S::P::TF:AQ:DA::::I:IM:E::AT:::N::AV:IEC:::T::Q:::::Q
NP1228A         ::::Q:-D::T::S:::EH:::L::I::E:T::N::::::T:L::EC:::A::Q:::::Q
VNG0478         ::::V::E:TTVG:::Q:T:G::::::F::::::::::::::::::R::::::A::::::
rrnAC0635       ::::LP::::::P::::SN:::::::::E::::A:::::VS:C:I:::::::::::::::
HVO_1376        ::::::-EE:::SKF::K::G::::::VE::::::::R::EA::::R::::::::::::E
Hbo0177         ::::::-E::::G:::ENN:::::::::H:::::G::::::G:::E:::H::::::::::
Hmu0975         ::::TA:::::::G::ADH::::::L:V::::::D::AA::S::::::::::::::::::
hla2320         ::::T:-:G::::G::::E::::::::::::::A:::DR:::L:I::V:::::::::::E

consensus       VAFLHPKSTGGVLVEFVEH
#oth            ......12...1.3.2.21
HQ2401A         ::::::R::::::C:::QQ
NP1228A         :::::::::::::I:Y:::
VNG0478         :::::::D:::A:I:::::
rrnAC0635       :::::::T:::::::L:::
HVO_1376        :::::::::::::::::S:
Hbo0177         :::::::::::::::::S:
Hmu0975         ::::::R::::::L:::::
hla2320         ::::::R::::::::::::