[Q] (PncA) COG1335 Amidases related to nicotinamidase 8 genomes BUD1008 8 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1100 rrnAC2100 HVO_2328 Hbo2011 Hmu1742 - hla1503 NP1274A HQ2280A

Pairwise sequence scores
Consensus score	1423	NP1274A	HVO_2328	Hbo2011	hla1503	VNG1100	HQ2280A	rrnAC2100	Hmu1742
853	NP1274A	1496	798	768	712	669	685	681	748
1051	HVO_2328	798	1473	952	902	759	751	816	884
983	Hbo2011	768	952	1517	802	751	735	828	833
1085	hla1503	712	902	802	1442	784	796	841	886
969	VNG1100	669	759	751	784	1407	835	901	854
949	HQ2280A	685	751	735	796	835	1430	939	1002
1067	rrnAC2100	681	816	828	841	901	939	1421	989
1102	Hmu1742	748	884	833	886	854	1002	989	1428

202 symbols
consensus       ------GLADDA-------VLVLVDFQQGFDEPAWGDRNNPDAEANAARLLAAWREADRP
#oth            123254554551211111111211.3.3..1434..2....11.23213..33..2234.
NP1274A         MPYRDYESLSL:ES:::::AIIC::V:::::RER::E:::::::RHI:E::::::::GH:
HVO_2328        ::MTAAD:P:::::::::::::CI:M:V:::D:::::::::EM::RV:D::::::A::::
Hbo2011         ::MTEF:A::E:DSETSAPA:::::L:T:::ADG::::::::::S::::::D::::R:F:
hla1503         MTERTA:V:::::::::::::L:I:::T:::::G::E:::::::SV::A:::R::::G::
VNG1100         ::::::MTERR::::::::A::::::::::AD:::::::::::::H:EE::::::D:AA:
HQ2280A         ::::::MSSTPP:::::::::L:::::::::HSE::T::::::::::::::SF:::R:::
rrnAC2100       ::::MVV:PETP::::::::::::::::::::SQ::T::::::::::::::T::::RSL:
Hmu1742         ::::::-MSGTP:::::::::::::::R:::::E::T::::::::::::::ST:::H:::

consensus       IAHVRHDSTEPDSPLRPGEPGFAWKPELAPEAGEPTFEKRVNGAFIDTGLEAWLRERDHE
#oth            22.1..2.1.21...16142.12213232.332.1315.2..1112113.451.113355
NP1274A         VI::::::::::::::::RS:NEF::AGE::P:::VVG::::S:::G:E:::L::::GVR
HVO_2328        VV::::::A:::::::SDGE:::::::AE:VD:::V:T::::SG::G:D::::::::::S
Hbo2011         R::::::::::T::::GDG::::::::T::VDE::::T:Q::SG::G:E::S::::N:C:
hla1503         ::::::A::::::::::DAS:::::::T:::::::::::S::::LL:S::DE::H::G:D
VNG1100         ::::::N:::AT::::Q::::::YTDG:::A:D::E:V:S:::::V::A::G:::D::TG
HQ2280A         :V:I::N:::S::::QK:Q:::DY:AA:S:TGD::E:I::::::::::::QQ::H:QNYK
rrnAC2100       V:::::N:::::::::R::::::F:R::S:::::A:::::::::::::::AD:::DTAS:
Hmu1742         :V::::::::::::::A:::::DY::::::VD:::A:R:::::::V::::G::::::G::

consensus       TLVVCGLTTDHCVSTTVRMAENRGFEVYVVADATATFDRE-LDGERFDADEVHRTALAHL
#oth            23.21.1.....1..12..11.1.1235223.....11.1132112341343..2...1.
NP1274A         RP:FV:F::::::::S::::::L:::P:::S:::::::::::G:T:YA:EQN::L:::Q:
HVO_2328        ::::::::::::::::T:::::L::D::LP::::::::::GH:::::S:::M::::::::
Hbo2011         :V:IV:::::::I:::T:::::L::API::S:::::::::GP::::YS:E:M::::::::
hla1503         ::::::::::::::::::::::::Y::A::::::::HA::GY:::AI:::TS::V:::::
VNG1100         S:::::::::::::::::::D::::D:TL:R:::::H::T::::::LPPSV:::::::::
HQ2280A         :::I::::::::::::A:::::::::I:I::::::::::T::NS:H:::PV:::::::::
rrnAC2100       :::I::::::::::::T::::::::D:V:PG::::::::T:::::H::P:L:::::::Q:
Hmu1742         SI:::::::::::::::::G::::::TF:A:::::::::T:::::::E:PL:::::::::

consensus       RGEFATVAETADLLARL-----
#oth            42...12331332446511111
NP1274A         SD:::::V:::T:::A:AERKA
HVO_2328        NR:::::V:S:::S:TR:::::
Hbo2011         YR:::D::T:D:V:T:::::::
hla1503         D::::::V:SG::R---:::::
VNG1100         ::::::L:T::TV::GP:::::
HQ2280A         SD::::IIP:EQAKHID:::::
rrnAC2100       ::::::I:T:D:VV:S::::::
Hmu1742         D::::::LS::AAVD:W:::::