[H] (CbiB) COG1270 Cobalamin biosynthesis protein CobD/CbiB 8 genomes BUD1039 8 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1578 - HVO_0587 Hbo0934 Hmu0508 Hut0152 hla0301 NP5308A HQ1411A

Pairwise sequence scores
Consensus score	2168	HQ1411A	NP5308A	hla0301	Hut0152	Hbo0934	HVO_0587	VNG1578	Hmu0508
1199	HQ1411A	2222	930	1032	995	1151	1047	995	906
1297	NP5308A	930	2198	1034	1024	1069	1027	1022	998
1513	hla0301	1032	1034	2445	1222	1189	1186	1121	1146
1461	Hut0152	995	1024	1222	2415	1115	1100	1152	1097
1539	Hbo0934	1151	1069	1189	1115	2267	1404	1149	1161
1536	HVO_0587	1047	1027	1186	1100	1404	2199	1208	1198
1482	VNG1578	995	1022	1121	1152	1149	1208	2228	1183
1494	Hmu0508	906	998	1146	1097	1161	1198	1183	2284

362 symbols
consensus       -------MPVIAAL------------AVAVAAALDAAVAEPPARIHPVALLGRAVAPL-D
#oth            111111134541443111111111112134131.15341...133....11.23134311
HQ1411A         ::::::::ITLGSI::::::::::::::I::IG::TIIG::::F::::::F:QL:DIV::
NP5308A         ::::::::NGSGL:L:::::::::::::::::::E:L:G:::::::::::::::::::GE
hla0301         MATAPLLT::L:S:A:::::::::::TL:I:V:::L:L::::::V:::::F:SV:GRF::
Hut0152         :::::::VTI:::APGEFVVRIQPGIC::L:L:::G::G:::ES::::::F::MI:::::
Hbo0934         :::::::V:LT:::::::::::::::::VL::G::V::::::::V::::::::L:SHA::
HVO_0587        :::::::V::T::A::::::::::::::VA:::::RGF::::::V::::::::L:S:V::
VNG1578         ::::::::TAA:VG::::::::::::::::GV:::::I:::::GC::::WF::::GVV::
Hmu0508         :::::::--:::PF::::::::::::T:LT::::ELLA::::::A::::W::::::::::

consensus       RSWSRPRLVGAVAALALPLAAAGVAAALVAAATTVSPWLGA---AVAGLVLFTTTSLRML
#oth            .42441421.334.322.2321442345152156343432111143.23211323.1.2.
HQ1411A         ::YDS:NI::ILI:TT::IGFGI:T:TS:YVVFS:NSQ::::::FA::C::::LI:::L:
NP5308A         ::F:W:A:A:T:::VGV:A::::::YLT::::AALGAAAA::::VT:::::W::::::L:
hla0301         ::::::::::VAV:VG::IGV:AF:GGI::::SFAL:AFS:LPVL:::TI::::V:::::
Hut0152         :E:PFS:A::TSI:::A:::V:FL:WL::EF::::-:V:SS:::I:::::::S:L:::R:
Hbo0934         :T::H:::::V:L:::A::GF::::GGV::::E:L:::V:::::LF:S::::AA::::::
HVO_0587        :E::::T:::::::V:::AL::::T::VTW:::L:::::::::::::A:A::S:::::::
VNG1578         :P:T::LA:::L::I:::::::ATVW:A:TV::WG:ALA:::::V:::::V:V:::R:::
Hmu0508         :A:R::::::::G:::V::T::VAV:V::V::GRA:T::A:::::A::GA::VA::::::

consensus       LAAAADVIEAT--ETDLDAAREELRALAGRDASSLSAADIRSAAVESAAENLADGLVAPL
#oth            .442341263222431231.15311..1...144.11242...1...3....1..111..
HQ1411A         :RTVH::VMM:::TA:VS:::Y:::::::::::E:D::H::::::::::::::::FIG::
NP5308A         :SS:::::::S::DN:PA::KAA:P:::::::A:::PPLL:::::::L::::S::::G::
hla0301         ::TT:E:V:L::::::P:::::SV::::::::TD::P::L:::::::::::::::F::::
Hut0152         :TR:R:::DVS::R:::ET:::R:P::V:::P::::PPL::::S:::L:::::::F::::
Hbo0934         :D:VR::TQ:A::::::::::T:::::::::::A:D::HV:::::::V::::S:::::::
HVO_0587        :D:::A:VS::AD:S:::T::Y:::::::::P::::::::::::::::::::::::::::
VNG1578         ::E:SG::A::RT:NS:::::RR::::::::PDA:::GEL:::::::T::::::::::::
Hmu0508         :SE:RST:G::::S:::::::GS:::::::::GP:::GQV::::::::::::::::::::

consensus       LAFAL---------GAPV-SLPL--GAAAAAWVKAVNTLDSMLGYRSKPVGWASARLDDA
#oth            41.32122112122314221123111112.112.11..1...1..12122.211.....3
HQ1411A         :::T::::::::::F:::::VSI:::V:S::::::I:::::::::::::I:T:::::::I
NP5308A         S::VV:::::::::LSF:::::A::A:::::AF:::::M:::F::PGR-F:::::::::L
hla0301         GG:::GATVGLAVG:SE::A:::AA:V:::V:::::::::::::::::::::::::::::
Hut0152         :::T::::::::::::QL:::SV:::V:::V:I::::::::::::::::::::::::::L
Hbo0934         F:::V:::::::::C::F:::::::A::::::::G:::::::F::::::I:::P:::::V
HVO_0587        :::M::::::::::F:A::::::::AVG::::::G:::::::::::H::::RVP::::::
VNG1578         A:::V:::::::::::A:V:::V:::::::::::::::::::::::::R::T::::::::
Hmu0508         A::VAGVVVGQAAALS::PA:A:::::GG::::::::::::::::::::::::P::::::

consensus       VMWLPARLTAVLLAVAAR--DPAALRRARAWAGAPPSPNSGWPMATLAAALDVRLEKPGV
#oth            2.11...33131123312223343452126323423...1....113.12143.12..13
HQ1411A         I::V::::::A::S:::GHPLLPLRQQV::D:AQTA:::A::::::I::L:PA::H::DT
NP5308A         M:FV::::S:A::GP::A::::D:PV:::RY:DK:A:::A::::G::::::N::::::DS
hla0301         ::F::::V::GC:S:::G::SIE:::W:AS:::K:G::::::::::A::::::::::::H
Hut0152         :::::::T::::I:L::::::FG::W:::G:R:::::::::::::::::V::T:F:::::
Hbo0934         ::::::::AG:::::SVAEFSLPFSS:V:TL:RR::::::::::::M::V:PA::V::::
HVO_0587        :::::::VS::::::V:G::A::TVA:VGEL:RR:S::::::::::::VL:ET::::::H
VNG1578         :::V::::A:::I:AT::::A:::VS::A:D::::::::::::::::::V::C::V::::
Hmu0508         :::::::IG:L:I:A::::::::::::::P:LDGV:::::::::GV::::HG::::::::

consensus       YELNPAAS-----LPDAADATRAVRIVARAGGLAYALAA----AVAWL------------
#oth            .5.23435111112.443526222241431.43.41324444332533223322221111
HQ1411A         :::RTS::::::::::KSV::Y:IQ:TR:::VI:IV:TITILEGIT::::::::::::::
NP5308A         :R::EL:::::::::A:::GQ::LSATR:::IA::VI::LVG:V:Q::::::::::::::
hla0301         :V:::D:::::::P:SVV::E::::L:GVS::V:V::::GWLL:TR::PAPAGVIG::::
Hut0152         :V:::D:T::::::::::A::::I::::I::TI:G:MSLLIA:S:QLSPGSLGLVAVGVG
Hbo0934         :D:D::SDTANTR::TT:::MQ:::VTN:::L::F:::G::::VI::F::::::::::::
HVO_0587        :L:DGGPE:::::A::::T:A:G::L:S:::LA:F:V:G::::V:::F::::::::::::
VNG1578         :::RE::A:::::::GL:ESR:G::V:ST::::::::T:::::::VYAGGGGL:::::::
Hmu0508         :A:DGGEQ:::::::STEISL:S::T::V:::::::::VVTTA::GG:P:::::::::::

consensus       --
#oth            11
HQ1411A         ::
NP5308A         ::
hla0301         ::
Hut0152         SC
Hbo0934         ::
HVO_0587        ::
VNG1578         ::
Hmu0508         ::