8 genomes BUD1105 8 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi - rrnAC1884 HVO_0789 Hbo0746 Hmu0825 Hut1871 hla1972 NP3162A HQ1157A

Pairwise sequence scores
Consensus score	2078	hla1972	Hut1871	HQ1157A	rrnAC1884	Hmu0825	NP3162A	HVO_0789	Hbo0746
1624	hla1972	2239	1540	1532	1542	1460	1460	1518	1518
1710	Hut1871	1540	2081	1588	1585	1555	1496	1564	1629
1767	HQ1157A	1532	1588	2118	1619	1581	1564	1615	1666
1848	rrnAC1884	1542	1585	1619	2189	1813	1646	1683	1647
1788	Hmu0825	1460	1555	1581	1813	2079	1624	1636	1656
1745	NP3162A	1460	1496	1564	1646	1624	2067	1696	1608
1816	HVO_0789	1518	1564	1615	1683	1636	1696	2090	1767
1855	Hbo0746	1518	1629	1666	1647	1656	1608	1767	2196

329 symbols
consensus       --------------MGLEAAFADG-PAFVPYLAAGDPDYESSLEYVEALARGGADVIELG
#oth            11111111112343431331.33211.11...11...2111121.....2.....11...
hla1972         MADRTAESAKTGNSEAIA:::::::::YI::::V::::::::KA:::::D:::::I::::
Hut1871         ::::::::::MTANSEIG:V:ES:E:::I:::V::::E::A::::::::E:::::IV:::
HQ1157A         :::::::::::MEEQ::AS::S:::::::::::::::::::G:A:::::::::::I::::
rrnAC1884       ::::::::::::::::::R::::E:::::::::::::N::A:::::::::::::::::::
Hmu0825         ::::::::::::::::::R::::E:::::::::::::::DA:I:::::::::::::::::
NP3162A         :::::::::::::::S::D::DE-::::::::::::::F::::A::::::::::::::::
HVO_0789        :::::::::::::::S::D::S:::::::::::::::::::::::::::E::::::::::
Hbo0746         :::::::::::MGNPE:D:::EN::A::::::::::::::::I::::::E::::::::::

consensus       LPFSEPIAEGPTIQNAVVRSLEAGMTPDRFFEFVEELDVD---VPLVCMTYYNLIYQYGD
#oth            ..........2...4.2..1112..1.21..2.1121..31112...........111.4
hla1972         ::::::::::S:::G:L::A:D:::::::::A:A::V::E:::A:::::::::::::::G
Hut1871         ::::::::::::::::I:::M:G::::::::A:::::::G:::I:::::::::::F:::S
HQ1157A         ::::::::::::::S:I:::::::::::Q:::::TD::::PTEI::::::::::::::::
rrnAC1884       ::::::::::K:::::I::::::::::::::Q:::D:::::::::::::::::::::::E
Hmu0825         ::::::::::S:::E::::::D:::S:::::::::::::::::::::::::::::::::S
NP3162A         ::::::::::::::Q:::::::G::::E:::::::T:::::::::::::::::::::::P
HVO_0789        ::::::::::::::::::::::G::::T:::::::D:::S::::::::::::::::R:::
Hbo0746         ::::::::::::::::::::::S:::::::::::::::::::::::::::::::::RF::

consensus       E-----------------AGPR---PFVERAAEVGIEGFVVPDLPAEEADPLREACDEFG
#oth            2221111222211111114.12111...11..21.13.1......1..11...3..1.11
hla1972         :AR::::SASDASGETAS::::::::::::::AA::::L:::::::::::::::::::::
Hut1871         ::::::::::::::::::::::::::::K::::A::A:L::::::::::::::D::::Y:
HQ1157A         ::::::::::::::::::E:::::::::K:::D::LS:::::::::::S::::T::N:::
rrnAC1884       GDSESRSDSENASGETASQ::::::::::K::A:::::L::::::G:::G:::T:::::D
Hmu0825         G:::::::::::::::::Q::E:::::::K:::::::::::::::::::G:::A::::Y:
NP3162A         -:::::::::::::::::::SQPVV::::::::::LK::::::::::::G::::::::Y:
HVO_0789        ::::::::::::::::::P::::::::::K:::::::::::::::::::G::::::::::
Hbo0746         ::::::::::::::::::S::::::::::K:::::LS:::::::::::::::::::::::

consensus       LDLVFIVAPTTKGDRLDRIMEQVSGYVYVQARLGVTGARDDVSDQTEESLARLAEYDVPK
#oth            ...1.......411..4211211...........1...221.122.331.3.2521.1..
hla1972         :::::::::::VD:::::::DR::::::::::::T::::S::::::TQ::D::R::::::
Hut1871         :::::::::::R::::KT::D:::::::::::::T:::::::::::D::::::R:W::::
HQ1157A         ::::::::::::::::NT::S::::::::::::::::::::::T:::S::S::DA:::::
rrnAC1884       ::::::::::::::::E:ML:::::::::::::::::::E::D:A::D:::::SDW::::
Hmu0825         :::I::::::::::::ASM:D:T:::::::::::::::K:::D:A:::::::I::W::::
NP3162A         :::::::::::A::::E:M::::::::::::::::::::E::::R:A:T::::EA:::::
HVO_0789        :::::::::::R:E::::::::::::::::::::T:::QSS:::::DS::E::TD:::::
Hbo0746         :::::::::::Q::::::::::::::::::::::::::Q::::G:::S::E:V::::I::

consensus       AVGFGIKTGEHAERIVAAGADGIIVGSALVDIVAEG--------------HENGDSTDTV
#oth            ......13.21..11.22....1...........2.11111111111111313123233.
hla1972         ::::::SS::::::::GG::::::::::::::::::::::::::::::::V:DDL::AE:
Hut1871         ::::::::::::::::S:::::::::::::::::D:::::::::::::::ADS:E::EA:
HQ1157A         :::::::::::::::::G::::::::::::::::S:::::::::::::::T:A::::T::
rrnAC1884       :::::::::A::::::S:::::::::::::::::::::::::::::::::::::::::A:
Hmu0825         :::::::N:D::::::S::::::::::::::::::::::::::::::::::::::PA:E:
NP3162A         ::::::SS::Q::AV:::::::V::::::::::::::::::::::::::::::::AP:V:
HVO_0789        ::::::SD:D:::::::S:::::::::::::::::::::::::::::::::::::DAE::
Hbo0746         :::::::::D::::::::::::::::::::::::::ASAPRQMQSNDAAA:::::DAE::

consensus       ADRLEAKARELKDGALRGAAQRAPQPERT
#oth            .1...311...23..31.44515253242
hla1972         ::::::LS::::A::E::Y:A:IEAA:SR
Hut1871         ::::::::::::::::::TPSA:VED---
HQ1157A         :::::T:::::T:::Q::YQK:M:K:DT-
rrnAC1884       ::::::::::::E:::::::E:-::::::
Hmu0825         :A:::Q::::::E::::::QN:-::::G:
NP3162A         :::::SL:::::S::VA:-K::Q:G::::
HVO_0789        :::::TL::::E:::VA::S::P:H::::
Hbo0746         :A:::S:::::::::E::L:::::ET:::