8 genomes BUD1126 8 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi - rrnAC2672 HVO_0041 Hbo1452 Hmu3084 Hut2199 hla0677 NP5268A HQ3719A

Pairwise sequence scores
Consensus score	2230	NP5268A	Hut2199	rrnAC2672	Hmu3084	hla0677	HQ3719A	HVO_0041	Hbo1452
1770	NP5268A	2213	1695	1711	1700	1526	1481	1465	1513
1810	Hut2199	1695	2223	1772	1758	1522	1512	1518	1574
1859	rrnAC2672	1711	1772	2284	1846	1553	1520	1500	1558
1833	Hmu3084	1700	1758	1846	2262	1550	1542	1540	1589
1796	hla0677	1526	1522	1553	1550	2285	1533	1610	1650
1772	HQ3719A	1481	1512	1520	1542	1533	2279	1632	1741
1763	HVO_0041	1465	1518	1500	1540	1610	1632	2265	1768
1859	Hbo1452	1513	1574	1558	1589	1650	1741	1768	2270

307 symbols
consensus       ---ETTNFLDIDDLTTDELDTVLDRAAAIKAG----ETDDRLDDQTLGMIFEKPSTRTRV
#oth            12243423111..21441.532.11.242.212111536442534.11.1.........1
NP5268A         :::--M:::N:::::REQ:E:::TE:ERL:::E:::T:A:AMAGD:MA::::::::::::
Hut2199         :::M:R:V:::::::SE::T:::::::T::::E::::AGNP:E:E::A::::::::::::
rrnAC2672       :::--MDI::V::::::::V:::::::::::DHGEGS:S:L::Q::::::::::::::::
Hmu3084         :::MP:HL::V::::::::T:::::::E:::D::::GAP:L::GH::::L:::::::::I
hla0677         MPLA:DD::::::V:PA:::AL::::::M::::::::::P::G:A:::::::::::::::
HQ3719A         :MPKSS:::::::::::::Q:I::::T:L:H:::::GDNAQFPG:::::L:::::::::I
HVO_0041        :ML:::H:T::::ISAS:::R::T:::D::S:::::DDETQ:TRA::A:L::::::::::
Hbo1452         :ML:::H:::::::::T::HH:::::::::::::::KE:P::E::::::L:::::::::I

consensus       SFETGMTQLGGHAIFLGPDDIQLGHGEPLKDTARALSRYVDVIMARLFDHADLEELAEYA
#oth            .....1.3.....3....1..1..11..22..1.1111.2.32.1.2.1.3.22111211
NP5268A         :::::A:::::::::::::::H::::::V:::::::::::::::::V:::::V:::G:::
Hut2199         :::::::::::::::::::::H::DS::V::::::V:::A:A::::::::::A:::::::
rrnAC2672       :::::::::::::V:::::::H::::::V:::::::G::::F::::V:::::A:::::::
Hmu3084         :::::::D::::::::::E:::::::::I::::::V:::::FL:::M:::G:V:::::::
hla0677         :::::::R:::::M:::::::::::::::R::::V:G::::GV:::::::E:V:V:::::
HQ3719A         :::::::::::::::::::::::::::::S::::V::G::::V:::::N:D::L:I:AH:
HVO_0041        :::::::E:::::L::::E::::::::::S::::V:G::G:A::V:::::E::L:I::HS
Hbo1452         ::::::::::::::::::E::::::::::S::S:V:::::::V:::::::E::V:I:D::

consensus       DVPVINGLTDDAHPCQTLADLLTIREQFGGFEDVTVAWVGDGNNVGQSFVLGAAMVGLDL
#oth            23..1.....1.............1251.31221311.1......2..1.2.1..211.1
NP5268A         T:::V::::::::::::::::::::::::::-:A:::::::::::C:::::::::::::V
Hut2199         T::::::::::::::::::::::::QE::::DT:R::::::::::A::L:::::::::::
rrnAC2672       :::::::::::::::::::::::::A:::D::::S::::::::::C::::I:::::::::
Hmu3084         S:::V:::::::::::::::::::::R::S:::A:::::::::::C:::::::::TD:::
hla0677         :C::::::::E:::::::::::::::TV:--::A::::::::::::::::V::::T:I:V
HQ3719A         :I::::::::::::::::::::::K:E::::D::::V:I:::::::::::I:::::::::
HVO_0041        :A::::::::::::::::::::::::HV:D:DE:QA::::::::::::::::C::A:I::
Hbo1452         ::::V:::::::::::::::::::::A:::::::QA::::::::::::::::C::A::::

consensus       TVATPEGYGIDDDVLDRAAELGGAPETTTDPEAAVADADVVYTDVWISMGQEDQREEKLA
#oth            2.1..32.22134.223.122.55122131.22.231..1..1..11...1.12.41.14
NP5268A         V:::::A:SV::A::E:::::::E:::::::::::DG::A::::::V:::E:SE:::::S
Hut2199         ::::::::E::EE:::::::::T:::::H::::::E:::::::::FV::::::E::::::
rrnAC2672       ::::::::::S:::A::::GF:N:::::H:::::::G:::::S:::V::::::K:DQ:::
Hmu3084         :::::::::V:ES:::::::::SV:A::::::::M:::::::::::V::::::K:::::R
hla0677         Q::::AE::M:PH:F:::::F:ADV:P:::::::IDG::::::::::::::::::A::::
HQ3719A         ::V::S:::M:QS:::Q:TA::HP:TIADT:G:::S:::::::::::::::::::N:::T
HVO_0041        :::::PA::V:::::EK:::::ST:TI:::::E::::::::::::::::::::::H:::Q
Hbo1452         ::::::E::::EE::AH:::Y::E:TIAET:AQ::::::::::::::::::::E:D::I:

consensus       AFE--GFQVNEDLLG--DAKVMHCLPAHRGEEITDAVIESDRALVWDQAENRLHAQKGLL
#oth            2..11.1121331.24211421..........112311122122..2.....1...11.1
NP5268A         V::SD::RIT:E::::::RPLL::::::::::V:::A::::N:I::::::::::::::::
Hut2199         :::::::::TTE::::::RTL:::::::::::V::E::::EN:I::E:::::::::N:::
rrnAC2672       D:::::::ITP:::::::RPF:::::::::::V:::A:::EN:V::N:::::::::::::
Hmu3084         ::::::::ITP:V:::::RTL:::::::::::V:::A::::N:I::::::::::::N:::
hla0677         ::::::::::A:::AGT::::::::::::::::::G:L::::::::::::::M:::NA::
HQ3719A         ::::::Y::::S::ANNS:Q:::::::::::::::E:LTGT:T:::::::::::::::::
HVO_0041        ::::::::L:::::SST:::::::::::::::::GD:L:DE:S::::::::::::::::I
Hbo1452         ::::::Y::::G::AET::E:::::::::::::SHD:L::::::::::::::::::::::

consensus       VELLEQ-
#oth            22.2353
NP5268A         TY::S-:
Hut2199         :W:A:RA
rrnAC2672       :W:S::A
Hmu3084         AW:S::E
hla0677         ::::GGE
HQ3719A         ::::SEN
HVO_0041        :::::E:
Hbo1452         ::::NK: