[R] (GloB) COG0491 Zn-dependent hydrolases, including glyoxylases 7 genomes BUD1164 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0231 rrnAC3474 HVO_1039 Hbo0533 Hmu1674 Hmu2473 Hut1117 - NP1974A NP2870A -

Pairwise sequence scores
Consensus score	1755	VNG0231	NP2870A	Hmu1674	Hbo0533	HVO_1039	NP1974A	Hut1117	rrnAC3474	Hmu2473
897	VNG0231	1880	674	671	667	455	659	551	706	671
951	NP2870A	674	1840	765	647	347	657	530	746	742
1001	Hmu1674	671	765	1872	617	424	631	608	762	778
935	Hbo0533	667	647	617	1777	640	725	607	735	721
634	HVO_1039	455	347	424	640	1277	535	491	500	528
1059	NP1974A	659	657	631	725	535	1612	657	814	800
1019	Hut1117	551	530	608	607	491	657	1698	816	859
1245	rrnAC3474	706	746	762	735	500	814	816	1745	1093
1243	Hmu2473	671	742	778	721	528	800	859	1093	1774

257 symbols
consensus       ---------MATALADGVWWLDLR-----GVNAYLVDD-------DGGVTLVDAGLPWDG
#oth            111111111144535332345236323123411323422222222354511312152354
VNG0231         MALRLAVPA:TAQ:PP::THV:CSTLD::MP:::V:V:::::::::NET::::::W:G:E
NP2870A         :::::::::::R:VT:::YR::IAWPEPV:A::::::::::::::-:E:::::::V:FPR
Hmu1674         :::::::::::RR:I::::E:::GLLPPLAS::F:L:ERDMDGTDGEA:::C:T::F:NE
Hbo0533         :::::::::-MSLEEGS:YR:RC::::::::::::::::::::::::TI::::::T:::A
HVO_1039        :::::::::---------------:::::---------:::::::---------------
NP1974A         :::::::::--------------M::::::::::::A:::::::::E:L::::::T:F::
Hut1117         ::::::::::::E::::I::F::::::::::::::LE::::::::KT:A::I:::G::TR
rrnAC3474       ::::::::::V:::::DI::Y::T:::::::::T:::::::::::::AL::::T::::H:
Hmu2473         ::::::::::V:R:::::::I::::::::::::::I:EAVAGDGAGS:::::::::::H:

consensus       RSLRAELAAAGYEPRDIDRVLVTHYDLDHVGGLARLD-AIDVPVYVGEADAPLVTGARRP
#oth            7644542553344343332112..1.3....2.4534346131123243.244152445.
VNG0231         QTV:DG:HT::V::G:::::::::::A::::T::::TP:L:A::::H:R:::Y:A:D:L:
NP2870A         :::SG::RSL::SLD:::::::::::I::::::::I-:D::::::I:AL:RR::RR:WS:
Hmu1674         P:I:D::::V::::G:L::::L:::::::::::E::QPEFTG::FL:R::YE::ENGAP:
Hbo0533         DRM::M:SR:NVF:AE:::::::::::::::T:GL::FDP:::I:AA:P::SFLL:DAT:
HVO_1039        -------------------:::::F::::::T::S:SLRD:::IHLA:P::SHL:::SK:
NP1974A         GTVVEAIE:::FDIA:LE:I:I::::F::::P:ST:-::V:T:::I:Q:::::L:::E::
Hut1117         :A:VK::::VDTD::KATQIAL::::I::::::GAC-:RK:GT::A:QP::DVLS:D:::
rrnAC3474       NE:I:G:SN::::L::L::I:L::F::::::::TAF::G::::I:::KR:::::::E:S:
Hmu2473         TQ:S:AI::::::L:::E::::::::I:::::::G:::GL:A:I:::::::E::A:R:::

consensus       PWRNHKGL--FQRAAAPFV-DLPDN-DVRPVADGDTVGGFTAYHTPGHTPGHTAYVHEDR
#oth            24643124113112645431441351423416.1152.4143231...1...22121335
VNG0231         ::TARN:IGALH:LYYRRL:::::L:PI:A:V:::DI:::H:::::::::::V::::::L
NP2870A         :::H:::V:::H:VVRRWY:S:S:Y::L:::E:D::I:A:RTF:::::N::::V:I:DET
Hmu1674         :SN::::::::H:::RTLC:P:::GI:L:::D::EA::R::S:A::::N::::V:::-:C
Hbo0533         :FG::::M::L:::TR::L:TA:K::E::R:N:::S::::GV:RA:::::::VV:Q:T:H
HVO_1039        SP:SL::V::A:::L:A:::ER:T::P:DV:R:::EL:::V::R::::::::::F::::H
NP1974A         SPYGI:R:::T:LVSG:::G:::ER:R:::LE::::::::::H:A::::::::V::::E:
Hut1117         D:A:R:TA::::::::LVL:SS:EQ:SIET:::::R:::L:V:E::::::::L:F:S:E:
rrnAC3474       :LG::::A:::::LVS:::::A::::::V:L:::::::S::T::::::::::VC::S:SL
Hmu2473         ::H:::::::::::M:G:::SP:T::RIE::T::::::E::V:A::::::::V:::S:RA

consensus       SVAFLGDLVRESDGRLEPSPWLLSYDTDRVERSIRELAARAPDFEVAAMGHGTPFRRDGA
#oth            23121..1132561527342124241332233.22432525331242321..41254414
VNG0231         ::::::::AYGLGD::K:TG::T:S:AAA::S:V:S:CR:::A::Y:CP:::P:L-P::D
NP2870A         ET:M:::::WAT::GFV:P:::D::::A:LAE::ARV:Q--ES:AH:CV:::PVVSP:A:
Hmu1674         G::L:::::W:EG:AMTTPI:FD:::M:::RA:V::F:::::A::::::A:::::V:::D
Hbo0533         GA::::::::::A:A:S::::FVC::AE:NRE:L:DI:D:IDP::A:CV:::E:L:T::Y
HVO_1039        G:G:V::Q::::N:S:GLL:GFIAT:AAENR::V:AF:::C:PVD:V:V:::E:VTEY:Y
NP1974A         :A:::::::I:R::E:A:A::FI:R:R::L:E::AD::::L:::::::::::::::TG:S
Hut1117         ::::V::::::RE::::A:::A::H:::A::S:::R::ELEL:VDIL::::::::VER::
rrnAC3474       :LGL:::::::DS::F::::::::::::A:T:::S:F:E:::::DI:VP:::V::EKN:S
Hmu2473         ::GL::::::::R:T:R::::::::A:GE:::::A::NG:::::A:LG::::R::E:::R

consensus       ERLAAL------AARL-
#oth            33.662111111.3432
VNG0231         D::---:::::::EA:P
NP2870A         :::RS:VVRRFG:D::R
Hmu1674         DV:G::::::::::T::
Hbo0533         GA:CWA:::::::D:V:
HVO_1039        GA:KR::::::::DK::
NP1974A         :::R:::::::::E:Y:
Hut1117         AH::D::::::::::::
rrnAC3474       ::::R:::::::::T::
Hmu2473         :::TE::::::::RE-: