[C] (AcoA) COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit 7 genomes BUD1175 11 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG2217 rrnAC0149 rrnAC2957 rrnB0200 HVO_2958 Hbo1576 Hmu3187 - hla0385 hla2574 NP0560A NP2542A -

Pairwise sequence scores
Consensus score	2856	hla2574	rrnB0200	NP2542A	rrnAC0149	VNG2217	Hbo1576	HVO_2958	hla0385	NP0560A	rrnAC2957	Hmu3187
1668	hla2574	2987	1246	1607	1503	1421	1486	1512	1514	1415	1390	1448
1718	rrnB0200	1246	2921	1364	1364	1542	1521	1595	1598	1593	1631	1611
1800	NP2542A	1607	1364	2951	1578	1563	1560	1573	1560	1603	1565	1537
1894	rrnAC0149	1503	1364	1578	2877	1618	1621	1691	1685	1556	1723	1691
2153	VNG2217	1421	1542	1563	1618	3246	1985	2041	2002	1867	1980	1963
2233	Hbo1576	1486	1521	1560	1621	1985	2778	2208	2117	1903	1943	1886
2279	HVO_2958	1512	1595	1573	1691	2041	2208	2853	2260	2001	2002	1958
2370	hla0385	1514	1598	1560	1685	2002	2117	2260	2841	1974	1938	1997
2221	NP0560A	1415	1593	1603	1556	1867	1903	2001	1974	2893	2079	1997
2281	rrnAC2957	1390	1631	1565	1723	1980	1943	2002	1938	2079	2861	2288
2312	Hmu3187	1448	1611	1537	1691	1963	1886	1958	1997	1997	2288	2873

428 symbols
consensus       -------------------------------------------------LSVLQRAPDDR
#oth            111111111111111111111111111111111111112333234245576467334626
hla2574         :::::::::::::::::::::::::::::::::::::::MGENDVDDTGSATDPL:DE:C
rrnB0200        ::::::::::::::::::::::::::::::::::::::MNMKNEAGSTD:PAPV:EDS:L
NP2542A         ::::::::::::::::::::::::::::::::::::::::::::MDTADAIDAFAEGENL
rrnAC0149       :::::::::::::::::::::::::::::::::::::::::::::::MTQD::N::::::
VNG2217         MALVLPNQSTETGQWVEIRWQRSPWKRLLRKSYSRRGRSSAHVRTGVPVTETIH:::::T
Hbo1576         :::::::::::::::::::::::::::::::::::::::::::::::::----------M
HVO_2958        :::::::::::::::::::::::::::::::::::::::::::::::::V:::::D:Q::
hla0385         :::::::::::::::::::::::::::::::::::::::::::::::::V::FD::Y::P
NP0560A         :::::::::::::::::::::::::::::::::::::::::::::::::M:T:::D:R::
rrnAC2957       :::::::::::::::::::::::::::::::::::::::::::::::::M:::::D:T::
Hmu3187         ::::::::::::::::::::::::::::::::::::::::::::::VVP::::H:D:T:Q

consensus       VRVLDEDGEVVDDATVPDLSDEELVEMYRDMRLARHFDERAVSLQRQGRMGTYPPLSGQE
#oth            413.123.43244362.113.2412321132332.1..3.11.1.....21.12122...
hla2574         Y:::GP::IPLP::::::::::RFRAI:::LVTT:R:::::::::::::I:::A:CA:::
rrnB0200        :Q:::AE:N:LPQ:S:::I::RQ:L:::ETIK::::::Q::I:F:::::LA::A:MT:::
NP2542A         H:R::A::QPLV:GYE:P:::DR:R:LH::::::::::::M::::::::I:::A::A:::
rrnAC0149       IQA::A:::I::PDLI::::::A::S::::::F::R::::MI:::::::L:::SS:A:::
VNG2217         Y:::::N::L::G:E::::T:D:::::::Y:K:::R:::::::::::::I::::::::::
Hbo1576         L::::::::P:GE--::::::D:::R:::E:WM:::::T:::::::::::::::::::::
HVO_2958        ::::::::T::GE--:::ID::T::::::Y::::::::T:::::::::::::::::::::
hla0385         ::::::G::::G:--::::D::A:::::::::::::::G:::::::::::::::::::::
NP0560A         :Q::::::Q::AEDG:::ID::T:L::::T::::::::::::::::::::::F::M::::
rrnAC2957       :QI:::::T:::G::::::::D:::::::YLK:G::::Q::::::::::::::::M::::
Hmu3187         :Q::::N:::R:G::::::A:::::AI::E:K::::::Q::::::::::::::::MA:::

consensus       GAQVGSAHALDDDDWIFPSYREHGAALVRGLPLKQTLLYWMGHEAGNAIPEDVNVFPLAV
#oth            11121136..324.24212....2.6442143154434112.314.35434342322421
hla2574         :SA:::T:::A:R:L:SYQ::::::IV::D:-:SEY:P::L:::S:TEAIA:G:::::NI
rrnB0200        :S::ATSL::AEQ::L::T::::A:KYAH:MD:VSLFEPLR:YRD:Y:::D::::M:EYI
NP2542A         A::F::MY:::::::VSYQ::::::VID::-G:ADYIR::::Y:S:::TLVEH:IA::NI
rrnAC0149       :S::::TY::A:E:T::YQ::::::LVA::::W-EYV:::::::::::ALG:::::::NI
VNG2217         :::IA::M::A:::::V::::::::S::::::::D:::::::D:R:::::AEE:I:TV::
Hbo1576         :::I:::F:::EE::M:::::::::::H::::::R:::::::::K::R::::A:I::V::
HVO_2958        :::I:::I:::EQ::MV::::::::S:L::::::::::::::::K::EM::G::L::P::
hla0385         :::I:::T:::E:::MV:::::::::::::::::::::::::::::::T::G:::::V::
NP0560A         A::::::L:::A:::V:::::::A::Y:::ID:D:::Q::::D:R:SQTAA-A::::V::
rrnAC2957       AS:::::F::R:G::A:::::::L:MY:K:W::SDD::::::S:S::SP::::QA:SF::
Hmu3187         ::::A:::::S:G::V:::::::A:LHAH:W::D:I::::::S:::SDP:DG:AA:T:::

consensus       PIATQIPHATGAAWAAKLRGEDR-AVLCYFGDGATSEGDFHEGLNFAGVFDTPAVFFCNN
#oth            2.221211.2.32.1422223451154211.1.1........13.1...122.22.2.1.
hla2574         G::AHL:::V:::::FDY:E::::V:AAH::G::::::::::AM:::::::::TL:C:H:
rrnB0200        :::::V:Q:M:M::GH::Q:KTET::::HL:::::::::::::::::::::V::::V:::
NP2542A         S::AHV:::V:M::::::::D:::::V:H::::::::::::::A:I:::::V::::V:::
rrnAC0149       S:GAHL:::V:WS::::K::DE:::GVVH:::::::::::::AM::::::E::T::::::
VNG2217         :::S:::::::MG::SQ:KD:SDT:FM::::::::::::::::::::::Y:::N::::::
Hbo1576         ::S::::::::::::K::Q:::S::::::::::G::::::::::::::::N::NI:::::
HVO_2958        :::S:::::::::::K::::::DT::I::::::::::::::::::::::::::N::::::
hla0385         :::S:V:::::::::S:::::ND::F:::::::::::::::::V:::::::::T::::::
NP0560A         :::::VL::::V::::D:K:D:I:VS:::::::::::::::::::::::::L::::::::
rrnAC2957       :::::::::::::::S::K:D:T::A:V:::::::::::::::::::::::V::::::::
Hmu3187         ::::::::::::S:::::::Q:E:VH:A:::::::::::::::::::::::::T::::::

consensus       NQWAISVPRERQTASATLAQKAEAYGFDGVQVDGMDPLAVYQVTREAVEKAR-------D
#oth            .1....1.222.1113.2.2..9...12.12...1....2.41252.431.312133223
hla2574         :G::::I:ES:::::D:F:E::G::::E:IR::::::::S:A::K::ADR:::::RNED:
rrnB0200        :::::::::::::::E:I:E::Q:::I:::R:::L::::::K:AS::LA::::::::::N
NP2542A         ::::::::QAA::::D:F:A:::::::P::R::::::::T:E:MD::LDR:K:SDDERPT
rrnAC0149       :::::::::::::::Q::::::D::::::::::::::::T:S::EA:R:R:V:::::::G
VNG2217         ::::::::::Q:::TD::::::A::::E:::::::::::::::AHD:I:::K::::::::
Hbo1576         :::::::::::::::::I::::K::::E:::::::::::::AA::A::K::K::::::::
HVO_2958        :::::::::::::::E::::::T:::I::::::::::::::S::KA:LD::K:::::::N
hla0385         :::::::::::::R::::::::::::I::::::::::::::S::KA::::::::::::::
NP0560A         ::::::::::Q:S:::::::::H::::E::L::::::::::K:::::::::HAADPSRD:
rrnAC2957       ::::::::::::S::E::::::N:::::::::::::::::::::::::D::H::::::::
Hmu3187         ::::::::::::::::::::::S::::E:I::::::::::::::S:::::::::::::::

consensus       PAGDEPRPTLIEAVQYRFGAHTTADDPSVYRDDDEVERWKRKDPIPRLEAFLRDTGLLDD
#oth            3554371.321.221............21..3331116.143..21.3.51.234231.1
hla2574         SPV:A:::A:::FLE::::::::::::TA:::P:A:DP:RAL::LD:M:::::E::RI::
rrnB0200        :GPG:R::::::S:::::::::::::::::::ES:E:A:RDR::VD:I:KY:YNE:I::S
NP2542A         D::TAS::S:V:::::::::::::::::A::T:EA::::R:W::L::F:G:::EF:::::
rrnAC0149       AN:G:QE:IF:::::::::::::::::D:::::A:::E:RER::LD:M:::::NCN::::
VNG2217         :DE::M:::::::::::::::::::::::::EES:::A::D::::::::T::VE:DR:::
Hbo1576         ::E::R:::::::::::::::::::::T::::S::::Q::Q::::::::T::::::R:::
HVO_2958        :GEG:G:::::::::::::::::::::T:::::E:::K::A::::::::::::E::RI::
hla0385         :ET:R::::::::I:::::::::::::T:::::::::S:::::::::::RY::SE:V:::
NP0560A         AP:RAC:::::::I::::::::::::::::::::::::::Q::::::::L::::R:::::
rrnAC2957       :PAG:L:::M:::::::::::::::::::::::S::::::Q::::::M::::::R:::::
Hmu3187         :::ED::::M:::::::::::::::::::::S:E:::::R:::::::M::::::R:::::

consensus       ERVAAIEESVEDEVADAIEAAESTERPDPDEMFAHVYAEMPPELEAQREYLEALRERHGD
#oth            35233235425541221125.1353114.63214211214143245.4331543233211
hla2574         DG::::H:EADEI:::::DF:::V:-:::AD::D:A::DL::::RR::DE:L:AVDE::E
rrnB0200        DLESE:QD:I:Q::SE:::T::Q::-AS::NIVE:::EDV:AR::E::DE:NR:::KYD:
NP2542A         :A:S:V:SD::AT::::VDQ:MAV:-::::DL::DA:::L:DDIKS::A::QR:::EY::
rrnAC0149       GKIDVMDDTIDERLGEI:DN:::HA-:::TDL:TD::D:STSNIDE::::F:G:::::::
VNG2217         AAIES::ADI::A:::::::::E:P::::AS::EN::::::QR::Q:L::FQSI:DEY::
Hbo1576         :K:D::QSE::::::E::K:::AEP::E:N:::TN:F:::T::VQ::A:AFAE:Y:E:::
HVO_2958        :G:E::::D:KGR::::::::::DP::::S:::N:A:::RT::IQ::Y:EF:::::KF::
hla0385         ::::E::TA::TR::E:::::::EV::K:Q:::E:A:::L:::::R:Y:EFA:F::A:::
NP0560A         :::::::Q::T::::::V:::::::::A::S::DN:::DR::::D::QRQ:DR::N:Y::
rrnAC2957       :::D::D:::Q::::T::DE::A::::K:E::::D::::::QR::Q:LD:::E::A::::
Hmu3187         :S:E:::S:IA::::::::T:::Y:::A:E:::::::::::QR:RD:LD:::::::::::

consensus       EALLEE--
#oth            33131431
hla2574         G:FQR:E:
rrnB0200        G:FS:VLE
NP2542A         K::R::H:
rrnAC0149       D::::SE:
VNG2217         :::::D::
Hbo1576         :GF:R:::
HVO_2958        :GF:R:::
hla0385         ::F:::::
NP0560A         :E:::-::
rrnAC2957       :V:::-::
Hmu3187         :V:::-::