[O] (SirA) COG0425 Predicted redox protein, regulator of disulfide bond formation 7 genomes BUD1177 10 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG5061 VNG5236 VNG6059 VNG6467 rrnB0285 HVO_1366 Hbo3419 Hmu3299 - hla0859 NP0978A -

Pairwise sequence scores
Consensus score	606	HVO_1366	VNG5061	VNG5236	VNG6059	VNG6467	Hmu3299	rrnB0285	Hbo3419	hla0859	NP0978A
406	HVO_1366	650	401	401	401	401	381	357	407	422	427
595	VNG5061	401	606	606	606	606	536	460	419	433	411
595	VNG5236	401	606	606	606	606	536	460	419	433	411
595	VNG6059	401	606	606	606	606	536	460	419	433	411
595	VNG6467	401	606	606	606	606	536	460	419	433	411
547	Hmu3299	381	536	536	536	536	604	465	404	416	408
468	rrnB0285	357	460	460	460	460	465	601	385	389	373
430	Hbo3419	407	419	419	419	419	404	385	698	431	438
434	hla0859	422	433	433	433	433	416	389	431	628	492
422	NP0978A	427	411	411	411	411	408	373	438	492	624

95 symbols
consensus       ----------MSADYDITETLDVKGASCPMPVVKTKSAIDDLAEGEILEVLATDSGSMSD
#oth            1111111222324432211....1.31.....1..1212.1.42132.112...1..1..
HVO_1366        :::::::VTSKMST:EP::::::::L:::::::::RG:V:E:ES::::Q:V:::::::::
VNG5061         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG5236         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG6059         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG6467         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu3299         :::::::::::::EF::A::::::::::::::::::::::::S:DAV:::::::A:::::
rrnB0285        ::::::::::::EAF::A::::::::::::::::::Q::::::::SV:::I:::::::::
Hbo3419         MPPILCVKFNTMN:TE::D::::::EN:::::::::QG::E:TA:DV:::V:::::::::
hla0859         ::::::::::-MSTETAA:::::R:QN:::::I:::G:F::::A::V::IV:::::::::
NP0978A         ::::::::::--MST:A::::::::EN:::::I:::G:F:::DA:DT:::V:::A::L::

consensus       IDGWASGTAGVELLDQEE----GDDVYKHYVRKTE
#oth            13...23.3.11111.211211132.12.122.13
HVO_1366        LK:::DA:D::AM:::::AEED::A:FR:FIQ:E-
VNG5061         :::::::::::::V::::::::::::::::::::K
VNG5236         :::::::::::::V::::::::::::::::::::K
VNG6059         :::::::::::::V::::::::::::::::::::K
VNG6467         :::::::::::::V::::::::::::::::::::K
Hmu3299         ::::::::E::::::::::::::::::R:::::::
rrnB0285        :E:::E::N::A::E:VD::::EG:::::::E::D
Hbo3419         :A:::DT:D:::::::S:::::::G::T:::Q:::
hla0859         :A:::ES:D:A::V::::ATED:Q:::::::::::
NP0978A         :E:::DS:D:A:::::::AEED:AA:::::L::::