[C] (AcoB) COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit 7 genomes BUD1180 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG2218 rrnAC2956 rrnB0199 HVO_2959 Hbo1575 Hbo3549 Hmu3186 - hla0384 NP0558A -

Pairwise sequence scores
Consensus score	2479	rrnB0199	Hbo3549	VNG2218	NP0558A	rrnAC2956	Hmu3186	hla0384	HVO_2959	Hbo1575
2044	rrnB0199	2537	2130	1741	1891	1897	1846	1850	1844	1935
1993	Hbo3549	2130	2535	1701	1820	1871	1848	1805	1806	1921
1944	VNG2218	1741	1701	2257	1836	1850	1782	1796	1818	1816
2200	NP0558A	1891	1820	1836	2493	2078	2040	2061	1999	2005
2203	rrnAC2956	1897	1871	1850	2078	2513	2119	2007	1989	2072
2134	Hmu3186	1846	1848	1782	2040	2119	2479	1956	1892	1969
2179	hla0384	1850	1805	1796	2061	2007	1956	2471	2112	2036
2176	HVO_2959	1844	1806	1818	1999	1989	1892	2112	2468	2181
2233	Hbo1575	1935	1921	1816	2005	2072	1969	2036	2181	2499

338 symbols
consensus       ---------SQETQNLTLVQAVRDGLYTEMERDDDVLVMGEDVGKNGGVFRATEGLYEEF
#oth            111113444567424123122231112311652241211.1...2........31.41..
rrnB0199        MSSTASAQTG:KA:S::::E:IQ:::::::SQ::T:V:L::::::::::::::DQ:::::
Hbo3549         MSSTAAPDSEPPIER:N::E:IC:::::::SQS:::V::::::::::::::::N::::::
VNG2218         :::::::::-----------------------------::::::Q:::::::::::::::
NP0558A         ::::::::M:T:::S:::::::::::KS:::::E::::L::::::::::::::::::D::
rrnAC2956       :::::MSTQDAN::S::::::::::::G:::::E::V::::::::::::::::Q::H:::
Hmu3186         ::::::::M:TD::D:::::S::::::G::D::E::::L:::::E::::::::Q::I:::
hla0384         :::::::::MS::::::V::::::::::::RE::::::L:Q:::::::::::::::FD::
HVO_2959        :::::::::-MSS::::I::::::::::::NL::E:::::::::::::::::::::WD::
Hbo1575         ::::::MSQ::Q::::::::::::::::::QA::R:V:::::::::::::::::::W:::

consensus       GDDRVIDTPLAESGIVGTAIGMAAMGLRPVPEMQFSGFMYPAFDQIVSHAARLRTRSRGR
#oth            131..1......1..2.211.1.24.11..1.1..1..1..1...2...12.1.2.12.2
rrnB0199        :E::::::::::A::I:AS::L:QT:MK:::::::M::::::::::::::::::S::Q:Q
Hbo3549         :EE:::::::::A::::S:::L:LS:::::A::::M::I:::::::::::::::S::H:Q
VNG2218         :::::::::::::::I:S:V::::Y::K::::I::::::::G:::V:::MS:::::::::
NP0558A         :E:::::::::::::I:S::::::Y:::::::I::::::::G:::L:::::::::::::D
rrnAC2956       ::::::::::::A:::::::::::Y:::::::::::::::::::::::::::::N:::::
Hmu3186         -P::::::::::A:::::::::::H::::::::::::::::::::L::::::::::::::
hla0384         :G:::V:::::::::::A:V:::::::K::::I::::::::G:::::::M::F:::::::
HVO_2959        :::::::::::::::::::::::::::K::::I::::::::G:::::::MG:F:N:T:::
Hbo1575         :::::::::::::::A::::::::::M:::A:::::::::::::::::::::::::::::

consensus       YTCPMVLRAPYGGGIRAPEHHSESKEAFYAHEAGLKVVIPSTPYDAKGLLAASIRDPDPV
#oth            122.112...1........1......1.12..1....14....311..1.2111......
rrnB0199        :SV:::I:::::::::::::::::::::FV::P:::::S:::::::::::::::::::::
Hbo3549         :SV:::V:::::::::::::::::::::FV::P:::::T::::H::::::I::L::::::
VNG2218         F:L:::::::M::::::::::::::::::::::::::AM:::::::::M:I:::::::::
NP0558A         F::::::::::::::::::::::::::::T:::::::::::::::T:::::SA:::::::
rrnAC2956       :N::LTV::::::::::::::::::::::V::::::::V::::KET::::T:A:::::::
Hmu3186         F:::::V:::::::::::::::::::::::::P:::::V::::A::::::::::::::::
hla0384         FNL::T::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_2959        ::L::::::::::::::::S::::::M::::::::::::::::::T::::ISA:::::::
Hbo1575         ::::L:V::::::::::::::::::::::::::::::::::::H:T::::ISA:::::::

consensus       IFLEPKLIYRAFREDVPEDPYTVPLGEAAVRREGSDVSVFTWGAMTRPTLEAAENLAEE-
#oth            1.1...1...1.113.1332.2.2121.32.11.4.22.2.2...11.122.11313422
rrnB0199        :::::::::::::::::TK::Q:S:N:::I::::::I::Y::::::::A:I:::::SQSH
Hbo3549         ::::::::::::K:K::TGS:E:::S::SI::::::I::Y::::::::A:I::D:::D:R
VNG2218         V:::::K::::::::::D:::E:E::D::::T::E:::::::::::Q::V::::::--D:
NP0558A         V:::::::::::::::::E:::::::::::::D:T:L::::::::V::::S:::SV::D:
rrnAC2956       ::::::::::S:::E::D:::::E::::K:::::A::::::::::::::V::::E:::::
Hmu3186         V:::::::::::::P:DAES:::::::::::::::::T:V:::::::::V::::E::P::
hla0384         :::::::::::::GE:::E:::::I:::VT::::G::A:::Y::::::::::::T:::::
HVO_2959        ::M::::::::::GE::::D::::I:::::::::T::::::F::::::::::V:::E:::
Hbo1575         :::::::::::::G:::::D:E::I:::::::::A:I::Y:Y:::::::I::::::E:::

consensus       GIDAEVVDLRTLSPLDRETIVESFKKTGRAAVVHEAPKTGGLGAEITATIQEEALLYQEA
#oth            21.2..1.2.12..2.4111211.12....21.....11...11.14211...1.21...
rrnB0199        :::V::I:::::::::I:::TD:::::::::I::::::::::::::AT:::::::VH:::
Hbo3549         :V:V::::::::::::T:::::::::::::::::::::::::::::SS::::::::H:::
VNG2218         R::V::::::S:::I:FD::I::::::::::I:::::N::::::::::::::::::::::
NP0558A         :::V::::M:::::M:::::::::::::::V:::::::::::AG:::::::::::Y::::
rrnAC2956       ::::::I:::::::M:TD::::::::::::T:::::::::::AG::I::::::V::::::
Hmu3186         -:::::I:::::::M:TD:V:::::R::::V:::::::::::AG:VV:::::::::::::
hla0384         :::C:::::::V::::::A:I:A:EA::::V:::::::::::AG::::I:::::::::::
HVO_2959        ::::::::I::I::::::::::::::::::V:::::::N::::::::::V::::::::::
Hbo1575         :::::::::::V::M:K::::::::::::::::::::::::::::::T::::::::H:::

consensus       PVKRVTGFDVPYPLYALEDYYLPEAARIEDGIREAVEF
#oth            .14.11.1.2.3..221....1.342.1321.321321
rrnB0199        :I::IA:::A:M::HS:::::::Q:V::Q:::::T:D:
Hbo3549         :I::I::::A:V::HGV::::::Q:V::QE::L:T:::
VNG2218         ::E:I::::::F::A:::::::::P:::AA::E::FD:
NP0558A         ::N::::::::::::::::::M::DT::::A:::TY:A
rrnAC2956       ::T:::::::::::::::::::::P:::K:::::::::
Hmu3186         :IQ::::::T:F::::::::::::S:::K:::TD:C::
hla0384         :::::::::::::::::::::::T:T:::E::::::::
HVO_2959        :::::A:Y:::::::::::::::SV::V:E::::::N:
Hbo1575         ::E:IA:Y:::::::::::::::SV::V:E:::N::::