[G] (CitE) COG2301 Citrate lyase beta subunit 7 genomes BUD1192 7 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0627 rrnB0257 HVO_1452 Hbo0102 Hmu0747 - hla2513 NP4244A -

Pairwise sequence scores
Consensus score	2065	VNG0627	Hmu0747	rrnB0257	NP4244A	Hbo0102	HVO_1452	hla2513
1562	VNG0627	2257	1174	1253	1230	1215	1214	1228
1415	Hmu0747	1174	2027	1222	1196	1014	1162	1129
1493	rrnB0257	1253	1222	2140	1383	1141	1163	1148
1453	NP4244A	1230	1196	1383	2034	1076	1154	1155
1443	Hbo0102	1215	1014	1141	1076	2437	1271	1334
1508	HVO_1452	1214	1162	1163	1154	1271	2070	1284
1567	hla2513	1228	1129	1148	1155	1334	1284	3306

446 symbols
consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
VNG0627         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu0747         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnB0257        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP4244A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo0102         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_1452        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla2513         MDRISVEHRIRMLYRVVREVRDDGTVGRLGDGHADRERHGVEPVNQPLAELRLLGEVGVE

consensus       -------------------------------GR---------G-----------------
#oth            111111111111111111111112222212322443334444234443223333122222
VNG0627         :::::::::::::::::::::::::::::MP::WTPPVKVAPETYKMGAAVVVH::::::
Hmu0747         :::::::::::::::::::::::::::::::--:::::::::-:::::::::::::::::
rrnB0257        :::::::::::::::::::::::::::::MA::LSPTILLLG:ERTA:::::::::::::
NP4244A         :::::::::::::::::::::::::::::::--:::::::::-:::::::::::::::::
Hbo0102         :::::::::::::::::::::::MCRLSRLS:KTVTVLGRPE:RCRIEGASELVVYFQTA
HVO_1452        :::::::::::::::::::::::::::::::--:::::::::-:::::::::::::::::
hla2513         VERLLVHRHVAEALVVGLAYRPSLRVFDRLAN:ELLVVASGH:TTVSRGRQIATVPPIKR

consensus       ----------------------------MARRSVLFSPGDRPELMRKAPGAGADVVVFDL
#oth            2222221111111111111111111111.3...1..1...31221...1432...31...
VNG0627         :::::::::::::::::::::::::::::T::::::::::Q:S::::::TT:::::::::
Hmu0747         ::::::::::::::::::::::::::::::::::::A:::Q:DKL:::ADS::::A::::
rrnB0257        :::::::::::::::::::::::::::::V::::::A:::NA::::::A:GD::::::::
NP4244A         ::::::::::::::::::::::::::::::::::::A:::S::I::::AASS::::::::
Hbo0102         APSGVG:::::::::::::::::::::::::::L:::::::::::::::S:::::LC:::
HVO_1452        :::::::::::::::::::::::::::::P::::::::::::::L::::::::::L::::
hla2513         HARRCASLLPLGRRRRRDDYVGGDGPPD:::::L:::::::::::::::::::::IC:::

consensus       EDAVAPARKAEAREAVRDVLADPDFDPDAEVCVRVNPVGSGAADDLDAVLSAG-------
#oth            ....2.32.43..22.321.223423223132..2223233332.232332441111111
VNG0627         :::::::::GD::R::S:L:TAA:::::C:::::::::::::G::V:::::G::::::::
Hmu0747         ::::V:D::QA::::::::::TV--ESTC:L::::::IDD:::R::SV:::G::::::::
rrnB0257        :::::::D:EQ:::S:QS::SAV--NSNSHI:::I::::VS:TA::GGI::DT:::::::
NP4244A         ::::::GD:::::R::A:::::LGDGN:I:H::::::::::::R:VA:AFAHA:::::::
Hbo0102         ::::V:SK:DD::A::::::S::S::::::IL:::ASE--TV:::::G::GPD:::::::
HVO_1452        ::::S:D:::::::::AS::S::E:::::::A:::::-:DAGR::IA::CA:H:::::::
hla2513         ::::::G:::::::H::A::::::::::::::::LTA--::P:A::::LIG::TGDEDGP

consensus       ----GP-----DSVMLPKAESADDVATVAGLLAERDADLPVLALVESAAGVLNAEEIAAA
#oth            11114211211.22121.1432321651343223322351.2.11.1.1.1.3.421..2
VNG0627         :::::F::::::::VV::VTD:::::::DS::::H::TS:::::::::::::::H:::::
Hmu0747         ::::E::::::::::A::VPD:NA:E:L::M::::::SG:::::::::::::H::::::V
rrnB0257        ::::S::::::::::::::S::E:ISALER::G:YN::::::::::::::::::A:::::
NP4244A         ::::A:::::::::::::::GS:::LRLRE::RGV::AQ:::::::::::::::D:::::
Hbo0102         :::::DVDVRL:GI:VS::GY:A:IRE:DNE::A:GWT:::F::I:T:R:::::PD:::E
HVO_1452        ::::P::::::::LVV:::T:::::TS:::AAR:VG::C::I:I::::::::A:P:V:::
hla2513         DDAE::::IRL:A:::::V::PER:DK::S:C:D:GL:PA:F::::T:::I:S::S::::

consensus       DATDALLFGAEDLAADIGATRTDEGTEVLYARERVVLAASAAGVDAIDTVYTDFEDEAGL
#oth            32.3112.....121.2..1.123.1..11..111121.3.121.....312223.4311
VNG0627         GP::::V::::::S::::::::::::::::::::::::::::::::::::H:AI::PSAV
Hmu0747         ::::::::::::::G:L:::::ES:R::AH::QHAL:::R:::::::::H:PAY::::::
rrnB0257        :P::::::::::::::L::S::SD:R::::::Q:::V::::::I:::::I:PEYG:LD::
NP4244A         A::::::::::::T:::::::::A::::::::Q:A:T:::::::::::::::::G:TE::
Hbo0102         GP:T::I:::::::::::::::E:::::::::::::VV:A:EEI::::::H::::::S::
HVO_1452        PD:A:VV:::::F:::V::::SE:::::::::::::V::A:::::::::LHV:YR:::::
hla2513         P::NV:V:::::::::V::::::::::::::::H:::::G::DI::::::::::S:AD::

consensus       REAAEFAARLGYDGKMAIHPAQVPVINDAFTPDDEDIAWAERVLDARDEADA--RGVFEV
#oth            1231321241.1...11...1..311.2.11.233421..32124.332223422...3.
VNG0627         AAD:R:::D::F:::L:::::::DP::::Y::TEA:T:::T:::::AADS::::-:::R:
Hmu0747         ::::TE:R::::::::V::::::::V:A:::::::A::::R:IVE:SEA::ERA::::V:
rrnB0257        :D:T::::Q:::::::::::D::A::::::::S::E::::::IIA:DE:T::::-:::::
NP4244A         :A:T:T::QF::::::::::D::A:::E:::::GS::E:::::VT:DK:T::::-:::::
Hbo0102         ::QT:::RS:::::::::::::::::::::::SPDQVE:::K::::::::ETSGA:::R:
HVO_1452        ::D:A:GR:::::::L:::::::::::E::S:::::V:::KK::R:::::AREG::::G:
hla2513         ::E:A::LT::::::L:::::::EP::A:::::P:KVE:::T::::::A::RDA::::::

consensus       DGEMIDAPLIAQAERILERAREAD--
#oth            .1......1131..1124..312451
VNG0627         ::::::::::::::::MR:::A::N:
Hmu0747         ::::::::QVR::::::A::E:--::
rrnB0257        :::::::::::::::V:::::::GQR
NP4244A         :::::::::VTR:::::Q::E::GVR
Hbo0102         :D::::::::::::::::::GASADR
HVO_1452        :::::::::VK:::N::D::G:SY::
hla2513         ::::::::::::::::V:::AAS:R: