7 genomes BUD1228 11 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi - rrnAC0482 HVO_1238 Hbo0309 Hmu1155 Hmu2705 Hut0530 Hut0646 Hut2118 hla0914 hla1719 NP2796A -

Pairwise sequence scores
Consensus score	2518	Hut2118	Hmu2705	Hut0530	NP2796A	hla1719	HVO_1238	Hbo0309	hla0914	Hut0646	Hmu1155	rrnAC0482
1751	Hut2118	2469	1656	1704	1586	1531	1497	1534	1540	1692	1657	1672
1923	Hmu2705	1656	2494	1957	1680	1760	1656	1701	1709	1789	1757	1747
1912	Hut0530	1704	1957	2483	1649	1773	1659	1718	1725	1785	1703	1704
2060	NP2796A	1586	1680	1649	2520	1675	1880	1922	1906	1922	1864	1891
1992	hla1719	1531	1760	1773	1675	2458	1785	1826	1888	1796	1754	1809
2151	HVO_1238	1497	1656	1659	1880	1785	2505	2178	1956	1928	1920	1909
2155	Hbo0309	1534	1701	1718	1922	1826	2178	2510	2000	1931	1919	1915
2112	hla0914	1540	1709	1725	1906	1888	1956	2000	2500	1956	1917	1921
2233	Hut0646	1692	1789	1785	1922	1796	1928	1931	1956	2503	2075	2115
2145	Hmu1155	1657	1757	1703	1864	1754	1920	1919	1917	2075	2505	2111
2185	rrnAC0482	1672	1747	1704	1891	1809	1909	1915	1921	2115	2111	2517

327 symbols
consensus       MEYTTLGSTGMEVSRICLGCMSFGSSDWREWVLDEEEGRELIERAIDLGINFFDTANMYS
#oth            .......2..31..211..1....252112.121324141211..11..11...1..3..
Hut2118         ::::::::::::::QL:::A:::::EE--P:M:GK::S::I::::::::V:::::::A::
Hmu2705         ::::::::::I:::K::::::::::G:--::M::RDDSEA:::::LE::::::::::V::
Hut0530         ::::::::::::::K:A::::::::Q:--D:M::A::::::V:::::::V:::::::T::
NP2796A         :::::::A::I:::::::::::::DD::::::RG::F:H::V:::L::::::::::::::
hla1719         :::::::D::AT:::LA::::::::EH--::M::::::::::::::::::T::::::V::
HVO_1238        :::::::D::::::::::::::::TPE:::::::::A:L::VD:::E:::::::::::::
Hbo0309         :::::::D::::::::::::::::T:::::::V:::A:K::VD:::E:::::::::::::
hla0914         ::::::::::TT::K:::::::::D:::::::::::::KAIV:::LE::V::::::::::
Hut0646         ::::::::::::::::::::::::::::::::::::GS::I:::::::::::::::::::
Hmu1155         ::::::::::I:::KL::::::::T:E::D:::::S:S:AV:D:::::::::::::::::
rrnAC0482       :::::::::::::::L::::::::T:E::D:::::D:S::V:::::::::::::S:::::

consensus       NGESERILGDVLEEYDRDEQVVATKVYFQMDDDNPNSGGLSRKAIEQELSNSLDRLGMDT
#oth            7....21..41.4321.1231..1.3213232341.23.....111...32..1....11
Hut2118         A::::E::::::S:::::::::::::R:PVGE:T::AS:::::T:Q:::DA:::::::::
Hmu2705         T::::A::::::G:::::::::::::FGE:G::-::RQ::::::::::::A:::::::::
Hut0530         S::::E::::::A:::::::::::::R:SGATEHR:AE:::::T:::::EH:::::::::
NP2796A         R:::::::::A:DGH-:E:S::::::::P:R:GD:::::::::TV:::::A:::::::::
hla1719         :::::A::::::A:::::RFT::::::GE::ES::::::::::::::::E::::::::::
HVO_1238        ::::::V::KA::GR-:::A:::S:::::::::D:::::::::::::::D:::::::::A
Hbo0309         E::::::::EA::GR-:::A:::::L::::::SD:::::::::::::::D::::::::::
hla0914         ::::::V::EA::GH-:E:S:::::A::::AES::::::::::::::::EH:::::::E:
Hut0646         L:::::V::N::S::::::::::::GF::::::::::::::::::::::A::::::::E:
Hmu1155         A:::::V::EA:SA:::::::::::GF::::E:D::::::::::::::::A:::::::::
rrnAC0482       M:::::V::T::DD::::G::::::G:::::E:::::::::::::::::::::S::::::

consensus       VDLYQIHRWDYDTPIETTLRALDDAVRRGKVRHVGASSMWAHQFAEALHTSDREGLERFE
#oth            2..1.2..2.21..122.121121..11113.13.1...111.12211311211124113
Hut2118         I::::T::V:PN::P:::::::S::::A:::::::T:::F:::LSDR:R::E::D:VSY:
Hmu2705         :::::::::::::::::::::::::::::Q:::I::::::::::QR:::V:Q::::A:::
Hut0530         :::::::::::::::::::::::::::::::::I::::::::::Q::::V::::::A:::
NP2796A         :::::::::::::::AQ::::MT:::Q::Q:::I::::::T::L:::::::::::::::A
hla1719         ::::::::::::::::E::S::::::::::::YL:::::::::::::::::::::Y:::V
HVO_1238        L::L::::Y:::::::::M:::::::::::T:Y::::::::::::::QY:A:SL::D::A
Hbo0309         :::L::::::::::::::::::::::::E:::YL:::::::::::::::::::L:FD::V
hla0914         I::::L::::D:::::E::A:::::::::::::::::::::::::::::::::::Y:::A
Hut0646         :::::T:::::::::DE::A:::A:::::QA::::T:::::::::D::A::E:::::::Q
Hmu1155         ::::::::::D:::::::::T::::::::QI::A::::::TY::::::R::E::D:T:::
rrnAC0482       :::::T::::::::::Q::::::::::::QA:::::::::T::::D::R::E::::::::

consensus       TMQNHYNLLYREEEREMLPLCEKEGVGVIPWSPLARGYLTRPHEEFDATTRGETDDYARE
#oth            ...11.1.2.......12.2122343112..1.112.211..223543.5.132155472
Hut2118         ::::::H:A:::::::::::T:::DM:::::G::GQ:F::::ID:LES:A::DPENFHNP
Hmu2705         :::DL:H:T::::::::Y:V::QWD:::::::::GA::::::::A:TR:::::HEKENIG
Hut0530         ::::L:H:T::::::::Y:V::::DI::L::::::A:::::::D::T::::::HE-LDYG
NP2796A         ::::::::A::::::::::F::::RL::M::::M:::::::::::YMS:K:A::::::Q:
hla1719         ::::L:::A::::::::V:::QR::I:ML:::::GA::::::Y:QD:::::::HET-:LG
HVO_1238        ::::::::::::::::T::::::Q::::M:::::::::::::::::E:::::R::EH:KG
Hbo0309         ::::::::::::::::::::::::N::::::::::::WVA:::Q:ARS:E:::::EL:HG
hla0914         ::::::::A:::::::T::::Q:::I::M:::::::::::::::DV:::L::::EEHLY:
Hut0646         ::::::::::::::::::::::R:::::::::::::::::::::::::::::::::::::
Hmu1155         :::::::::::::::::::F:QRDA:A:::::::::::::::::::::::::Q:::::::
rrnAC0482       :::::::::::::::::::::D::N:::::::::::::::::::QVEE:V::::::::::

consensus       H-PYFEG-GGREINERVQELADEKGVTMAQIALAWLLHKEWVDAPIVGTSSIEHLEDAVE
#oth            311.721111211.2.121..112112...11.2.334214111..2.11122...3..2
Hut2118         TDE:TR:::::::::::E::::DY:::::::::::QYQN:Y:T::::::T:V::::::::
Hmu2705         L:::D::P:S:::::::::::::::::::::::::HFEN:YT::::L:::::::::A:::
Hut0530         T:::H::P:SE:::H::A:::ADY:::::::::::HFQNDH:::::::::::D::::::A
NP2796A         ::::ADN::::::::::::::AD:::S::::::S:V::::::::::::A:KLS:::::::
hla1719         R:::R:::::E:::R:IE::::::D:K::::::R:VAG::V::::::::::V::::::::
HVO_1238        ::::::::::::V::::E::::::::K:::L::S:V:::D:::::::::::::::::::K
Hbo0309         ::::L:::::::::::::Q:::::::K::::G::::F::D:::::::::T::::::::::
hla0914         ::::R:::::LAV::::A::::::::K:::::::::F::::::T:::::T:V::::::::
Hut0646         :::::::::::::::::A:::ADY::::::::::::::QDA::::::::T:V::::::::
Hmu1155         :::::::::::::::::::::::RDA:::::::S:::::DA::::::::T::::::Q::A
rrnAC0482       ::::Y:::N:::V::::::::::YDAS::::::::V:D::::::::I::::L::::E::A

consensus       ALDIDLSDSDVEYLEEPYEPVRVSGHE
#oth            .1112..3.1421..1..111213.11
Hut2118         :ME::::::::::::A::::QPIV:::
Hmu2705         ::E::::A:EM::::::::::P:Y:::
Hut0530         ::::S::A:::::::::::::A:F:F:
NP2796A         ::E:::::::LA:::A:::::P::::D
hla1719         :::V::::::::W::::::A:::::::
HVO_1238        ::::T:::::ID::::::Q:::::::D
Hbo0309         ::::S:::::ID::::::::::::::D
hla0914         :::::::K::M:W::::::::::::::
Hut0646         ::E::::E::QA:::::::::P:::::
Hmu1155         ::::S:::::I:W::A:::::P:::::
rrnAC0482       ::E::::E::::W::A:::::::::::