7 genomes BUD1230 10 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi - rrnAC1484 rrnAC2203 HVO_1225 Hbo0332 Hmu0407 Hmu1922 Hut1379 Hut1639 hla1493 NP4146A -

Pairwise sequence scores
Consensus score	1107	Hut1379	hla1493	NP4146A	HVO_1225	Hbo0332	Hut1639	Hmu0407	rrnAC2203	rrnAC1484	Hmu1922
616	Hut1379	2488	428	503	479	480	465	483	479	848	919
657	hla1493	428	1472	494	547	529	530	542	580	469	469
711	NP4146A	503	494	1213	572	593	599	612	603	514	505
798	HVO_1225	479	547	572	1182	905	588	659	635	556	530
722	Hbo0332	480	529	593	905	1194	542	590	581	567	538
755	Hut1639	465	530	599	588	542	1068	783	780	484	479
803	Hmu0407	483	542	612	659	590	783	1069	856	493	501
830	rrnAC2203	479	580	603	635	581	780	856	1090	501	511
678	rrnAC1484	848	469	514	556	567	484	493	501	2443	1308
664	Hmu1922	919	469	505	530	538	479	501	511	1308	3170

441 symbols
consensus       ------------------------------------------------------------
#oth            122111111112112321213231233223322221122223323333332232232222
Hut1379         MSDDDERMDRAERIKNLRQGRRGGDPEQTDTDAMSDDSDDDSNPRSDDADAEKPTADDAE
hla1493         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP4146A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_1225        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo0332         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hut1639         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu0407         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC2203       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC1484       :MSDDERMDRAERIRQMREGNKA:ETTDDTAESD::::::EASADGSGKQPDDEGETEAT
Hmu1922         MSDDDERMDRAKRIRRMREGQRSGDDADDSGEADADDTEADDAATDAADEPEAPTDDESE

consensus       ------------------------------------------------------------
#oth            231222323221323122322222221222222223233233222222222122222221
Hut1379         ADESEQSPDTVAGAGDTAESDEPTETAENADSAKTDVSEERARTNQGDGQPSKGAETNED
hla1493         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP4146A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_1225        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo0332         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hut1639         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu0407         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC2203       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC1484       AGEAADAEPATAASDDASNEA::::::::::::AAADGQVAND:::::::::::::::::
Hmu1922         TTEAADEPEATAESSDAASEAVDDTEADDEATDAAEDPAVTTDDPPATDEESPSETEADD

consensus       ------------------------------------------------------------
#oth            222222122232311111111111111111111111111111111111111122221122
Hut1379         GADSVPGESDSDED::::::::::::::::::::::::::::::::::::::ADALSAAE
hla1493         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP4146A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_1225        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo0332         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hut1639         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu0407         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC2203       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC1484       ::::::GDTDTDSD::::::::::::::::::::::::::::::::::::::::::::::
Hmu1922         AVTDPEGDTAAERDEPSERTHATPQNEAAQQPARADGASQGTDGTQTSDDSMNEGTSASD

consensus       -----------------A------------------------------------------
#oth            222222223545435453332342323433343433443111121121122212221222
Hut1379         AAARAAAEFETDTDLSD:EATGDAAASETPDEAAAPAGA:::::::::::::::::::::
hla1493         :::::::::VRKRAQNQHKSTDPVITPDNSGDTVIGIFA:::::::::::::::::::::
NP4146A         :::::::::::::::::-::::::::::::::::::::::::::::::::::::::::::
HVO_1225        :::::::::MRQDAITTE::::::::::::::::::::::::::::::::::::::::::
Hbo0332         :::::::::MSQEPQTA:::::::::::::::::::::::::::::::::::::::::::
Hut1639         :::::::::::::::::-::::::::::::::::::::::::::::::::::::::::::
Hmu0407         :::::::::::::::::-::::::::::::::::::::::::::::::::::::::::::
rrnAC2203       :::::::::::::::::-::::::::::::::::::::::::::::::::::::::::::
rrnAC1484       :::SAATDQSDTDAMAA:QRAAEASAQMTPENVDAGVAD::::QPTDDLSASASPMQGPT
Hmu1922         PEESNTTDEGSPDPEAI:QRAAQAAASVSGGGTETQSSQAGGGEPTP::AETAAAVQEAS

consensus       --------------------------------A---DAEQTAEEGQVLEFRLGDETYCVD
#oth            1111111121221212222212222221115537556644242542....6..313..21
Hut1379         ::::::::::::::::::::::::::::::TI:GADVE:T:E::TR:::::::E:R::L:
hla1493         ::::::::::::::::::::::::::::::AEVLMAAI:TD::PTK::::G:::G:::L:
NP4146A         ::::::::::::::::::::::::::::::::-MSE:QP::T:TK::::::::::::::S
HVO_1225        ::::::::::::::::::::::::::::::MS:DET:::DS:::V:::::Q::P::::::
Hbo0332         ::::::::::::::::::::::::::::::VPNTDESD:ESVR:I:::::K:::::::::
Hut1639         ::::::::::::::::::::::::::::::::-:::---M:DTI::::::E::S:::::S
Hmu0407         ::::::::::::::::::::::::::::::::-:::---MSTT:::::::E::E:::::S
rrnAC2203       ::::::::::::::::::::::::::::::::-:::M:A:S:TT::::::Q::S:::::S
rrnAC1484       GVELPDQELIEEAMASDNTATTEGGAR:::AA:IDD::T::E:LVR::::A::::Y::L:
Hmu1922         GVELPDQEQIDAALAASDESTADAASTETAPS:VESESTT:E:STR::::T::::H::I:

consensus       IDYVTEIVDRGELTRVPNAPDHVEGVMDLRGRTTSIVDPKVLLDIDAE-GAEKRIIVFDP
#oth            .3413...26242.41..213113..2....21.1.21..54341353215461111..3
Hut1379         :E::E:::REESV:::::T:EY:T::V::::QI:T:L::::AA::ETD:DGDRLM::::A
hla1493         :GVID::::A:::::I::S:::::::::::::::T:::::T:FA::E:::PRE::V:::D
NP4146A         ::F::::::M::::PI::S:P:::::I::::N::::I::::G:::EG:L:E--::VI::S
HVO_1225        :E::S::::K:Q::A::::::Y::::::::::::::IN::S::S:::G::ES:::VI:::
Hbo0332         :E::S::::K:S::A::::::Y:D:::::::::::::N::A::NV::AD:ES:::VI::S
Hut1639         ::H::::::I::V:S:::S:R::R::::::::::::::::IVFG:NED::::R:::::::
Hmu0407         :::::::::V:D::T:::::R::::::::::::::::N::SVFG:GDG::::Q:::::::
rrnAC2203       :::::::::I::::S:::::P::R:::::::::::::::::VFG:GD:::::::::::::
rrnAC1484       ::::E:::K:ESV:::::TD:Y::::V::::QI:T:LN::EMM::ESD::S:NL:V:::A
Hmu1922         :SL:E:::K:DTI:::::TDEYI:::V::::QI:T:L:::A:::::::::Q:SLM:::::

consensus       EIFEDQGAAGWLVDEVYQVVQIAEEDVDDSPVEDD--SIRGVIKRD--DDFVIWIDPDV-
#oth            342214434..3..2.51.341443213421565424314.2121111241.1.24.672
Hut1379         DV:::H:EI:::::A:D::SL:::S::KE::IQEP::Y:N:::E:E:::E::::TT:EL:
hla1493         DEIDEG:TV::M::::F::RDV:P::::QATTV:::KGVN:IV:S::::R::V:VS:::E
NP4146A         :::D:ERSV::A::S:EE:SD:DL:E:::::::QE::H:Y:L:::E::E:::V::::KTM
HVO_1225        NK:::EA:T:::::::::::RVSMD::E:P:L:K::D::E::::::::G:L:V::S:--:
Hbo0332         NK:::DA:I:::::::::::RVSMDEIEEP:L:K::D::E::::::::GEL::::S:VN:
Hut1639         ::IA::E:::::::::H::R::D:G::::::GGA:SA::K::V:::::EG::::V::VA:
Hmu0407         ::V:::S:::::::::D:::::SD:Q:::::AA:SDG:::::V:::::::::::V::R::
rrnAC2203       D:V:E:::::::::::::::::TP:Q::R::AN:A:G::::::::::::S::::V::AI:
rrnAC1484       GV::E:::M::I::::R:::PV::SE:NTA::DG:::Y:N::VD::GE:E:::::E::D:
Hmu1922         :A:D::::I::I::::R::APVV:SEINEP::N:E::Y::::VD:::::G::::TK:E::

consensus       --------------VHAED--
#oth            222222223234432334511
Hut1379         :::::::::::ALD:EET:::
hla1493         EIGDLDAAELGAEGEE::A::
NP4146A         DNEFAAGEELATPDAVS:S::
HVO_1225        :::::::::::::::::IE::
Hbo0332         ::::::::::::::AV::N::
Hut1639         ::::::::::::::::::-::
Hmu0407         ::::::::::::::::SN-::
rrnAC2203       :::::::::::::::::G:::
rrnAC1484       ::::::::VLGNATADG::::
Hmu1922         ::::::::AIKLATAEET:DG