7 genomes BUD1263 10 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0913 pNG6085 rrnAC1398 HVO_1640 HVO_A0625 Hbo2355 Hbo3205 Hmu1907 Hut0994 - - HQ2854A

Pairwise sequence scores
Consensus score	3461	HVO_1640	HQ2854A	Hbo2355	HVO_A0625	VNG0913	pNG6085	Hbo3205	Hut0994	rrnAC1398	Hmu1907
1232	HVO_1640	4330	554	746	770	726	689	1122	1054	1093	1094
1936	HQ2854A	554	4410	1996	1864	1543	1598	1088	1375	1299	1287
2305	Hbo2355	746	1996	3761	2146	1752	1737	1308	1572	1510	1597
2374	HVO_A0625	770	1864	2146	3504	1764	1857	1375	1563	1572	1600
2167	VNG0913	726	1543	1752	1764	3658	2268	1244	1493	1319	1458
2181	pNG6085	689	1598	1737	1857	2268	3821	1217	1536	1385	1460
1832	Hbo3205	1122	1088	1308	1375	1244	1217	3655	1778	1574	1585
2172	Hut0994	1054	1375	1572	1563	1493	1536	1778	3614	2071	2028
2186	rrnAC1398	1093	1299	1510	1572	1319	1385	1574	2071	3983	2158
2151	Hmu1907	1094	1287	1597	1600	1458	1460	1585	2028	2158	3420

726 symbols
consensus       -----------------------------------------------------------A
#oth            111111111111122222221212223234324423323333333343555444443559
HVO_1640        :::::::::::::::::::::::::::::::::::::::::::::::::::::::::MVG
HQ2854A         :::::::::::::MFQCPSSNNINSWLPCISDPSTDLGQLDSSSNQDHTDETHTIALRQY
Hbo2355         :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::V
HVO_A0625       :::::::::::::::::::::::::::::::::::::::::::::::::MTRLR:::::P
VNG0913         ::::::::::::::::::::::::::MPSSPDWE:::::::::::::GVGRVLR:::::T
pNG6085         ::::::::::::::::::::::::::MLSLPDSDTNTGASEEVHIESGPGSRLRHWVVSN
Hbo3205         ::::::::::::::::::::::::::::::::::::::::::::::MLRTLARHLRPAV:
Hut0994         :::::::::::::::::::::::::::::::::::::::::::::::::::::::::MAS
rrnAC1398       MLPVPVVRVFIGDTHTRALANGILKAHPIPCGAFRLQPRRGVARPHPGSYTRAKAQLPTM
Hmu1907         :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::-

consensus       TALRRFGVALLLC-------------SGLALLARGVAAANG-GSLAGSSRDSLAVPRWLY
#oth            56515435643543221111111111544443463422321142.2445334232.2..3
HVO_1640        S:V::GA:WFATF:::::::::::::AVASVTFSTS:F:HA:::::::L:-:VPA:F::-
HQ2854A         IDIS:V:HST:V:FRSYLIVGLISII:LIGMFSGET::S:AAVG:SEA:ENA:SI:::::
Hbo2355         :RH:FVAR:FA::LAV::::::::::I:V:::::::::S:AAVG:GQA:::P:S::::::
HVO_A0625       IS:::::LG:::A::::::::::::::L:S:::DPA::S:AAVG:::A:Q:N::::::::
VNG0913         P:V:IGAQFVVW::::::::::::::VA::A::GT:G:S:::LT:SK:PK:T::::::::
pNG6085         :K::L:VQFV:WV::::::::::::::I:T:FTET:::G:::MT:SKQP::T::::::::
Hbo3205         AC::Q::SLAVTV:::::::::::::V:V:A:S:P:L:HA::-:::::LQ-:AP::F::V
Hut0994         PRS:EL:HR::AVAA:::::::::::L:V:G:LVPS:::H:::::GA:A:E:VT::T::F
rrnAC1398       :SG::RT:::VV::::::::::::::GLGW:A:T:T:S:H:::::::GG:E::TI:T::F
Hmu1907         -M:::RV::V---:::::::::::::VA::V::V:R:::H::::::QDI:EP:TI:T::F

consensus       LATGGATVGASALLASFVTDRRFIDRIHNWRR-PLAGVG-GARRAARAAGRALGIAVLAL
#oth            141..13111.1.112.1..2332533353461354677265557457626441233342
HVO_1640        VVS::GV:CV:F::SA::::DETL:AFERAGV:RIG:LA:::VAT:E::LKL::V:A:V:
HQ2854A         V:::::AI:::::::G:I::::LLN:::TYGS:T:SSWH:PLYHWG:HF:A:I::LLATI
Hbo2355         V::::::I:::::::::::::::VL:::R:T::TF:AQE:T:::VGTGLLN::::GL:::
HVO_A0625       ::::::::::::::::::::::::E:V:L:QTG:D:::SD:LL::L:V::GV::L:::::
VNG0913         :::::::I:::::::::::::A::A:LDD:SY:::PSA::RL::L:VWG::T::VV::V:
pNG6085         :::::::I:::::::::::::A::RYL:::SL::GPT:D:DWWTPI:WI::SF::V::G:
Hbo3205         VLS::GV::V:F:FS:::::TEIL:AVA:Q:::R:DLSKSLI:SNLSYV:PVVSL::::A
Hut0994         :T::::I::::F::::::::::L::EL:G::A:TIPFH::--:T:VGSIV::G:VLGMIA
rrnAC1398       :S::::A::::F:::::::::T:VE:::::G::::S:--::FEGIL:L::QLV:LGG::A
Hmu1907         :S::::A::::F:::::::::AL::A::D::::AV:V--:P:::::V:SL:V::::GVV:

consensus       VVVLGLTGPQVPTANLAILLVFVGWRAGLTMLTYLVGNVWPALNPWRTIAT-------AL
#oth            2244.34..35243122123211151.133153.23224.441..223235111111143
HVO_1640        ::AF::F::P:GI:::GV:::W:::W::F::AA:::::A::LV:::::LGA:::::::::
HQ2854A         II:R::::::I::V:A::II::A:F:::I:IVI:AF::::TV:::A:S:T:::::::::I
Hbo2355         ::YR:VA:::I::V:::VVV::A:M:::F::F:::::D::S:::::Q:V:A:::::::R:
HVO_A0625       A:S::Y:::::::V:F:VIV::A:L:::Y:::S:::ADT:R:::::::LVS::::::::V
VNG0913         A:Y::F:::AL:::SFT::IA:A:G::A:PI:S:V::::::I:::::A::::::::::V:
pNG6085         A:Y:::::::L:::SFT::VT::VV::::P:::::G:::::::::::G:VS:::::::L:
Hbo3205         ::WF:V:::A::L::F:V:T:W:::W::F::F::::V:L::LV::::AL:RAVGRSLSWQ
Hut0994         I::I:YV:::SGLS:::::::W:::W::Y::SA::L:ET:STV::::::T::::::::W:
rrnAC1398       :F:V:FF::TNART:::::::W:::W:::A:T::::::S:AT:::FK:L:K:::::::L:
Hmu1907         :::V:YL::TDASS:A:::::W:::W:::S:SA:::::S:::::::::V:E:::::::LV

consensus       P----SGFRT---YPARLGRWPAVAGLLALVWIEVVSPLATRPSLLATVVLGYSAVTVAG
#oth            22222436351111154233..114.124.112.13222255144.132232.221123.
HVO_1640        RGRFAT:G:LSRP::D:::S::S:::::G:::L:::::::AN:RA::V::VA::L:::G:
HQ2854A         :TIPR:IQIP:::::S:F:::::LC::FG:I:::TTTGITA::T:::L:IF::LL:SII:
Hbo2355         :::::N::VE:::::QQ:Q:::::::::::::::TTTGVTN::A:::SA:::::::::V:
HVO_A0625       :::::N::VS:::::E::::::::::I:::::V:TATAVT::::V:::ALVA::V::L::
VNG0913         ::::::::V:::::::S:K:::::C:::::::V:::F:IS:V::V::::LVV::V:::::
pNG6085         :::::A:H:::::::RE:A:::::G:::L::::::IF:VS:I::I:SLAI:::::::I::
Hbo3205         S::::RFS:ESRPLSE:V:S::::V::IT:::V:::::V:SN:QT::VA::::T::::G:
Hut0994         ::::::LD:::::L::-V:A::::V:::T:I:::::::::DD:T::S:::V:::V::L::
rrnAC1398       ::::::LN:S:::::::V:S::::G:::V:::V:::::::DQ:R:::S::A::TVL:I::
Hmu1907         ::::::LDLR:::::D:::T::S:F::::::YL:::::::ENA:::::T::A:::::L::

consensus       AVLFGPDAWFRNADPVSVVFRLYGRVAPV-------------QRDD-DGLRVRLPGMRLT
#oth            .2421434..542..332313311331131111111111111434621423443.145.4
HVO_1640        ::VY:-:::::R::::AR::::::LL::::::::::::::::R:G:GG::SISV::AG::
HQ2854A         :MI:Q-E:::::I:::::F::F:S:A::L:::::::::::::KWTN:GQ:::SI:A:T:V
Hbo2355         ::A::TGP::::V:::::F:::::::::F:::::::::::::SW:R:GT:HAH::::::V
HVO_A0625       ::AV:A::::DKV:::::FLQF::::::::::::::::::::RL::::::SF:::::::V
VNG0913         :::V::E:::H:::::::ML:C::A:GI::::::::::::::::YP::RV:AV:::S::Q
pNG6085         ::::::::::E::::L::L::FF:A:::::::::::::::::K:R::GK:T:K:::SD::
Hbo3205         ::RY:-S:::ERI:::TR::H:::LL::I::::::::::::::::G:::IS:SV::SV:A
Hut0994         ::V::S:Q::DRV::I:T::TY::H:::IATVSTRVGEGTDQ:::SP:R:T::P::VG::
rrnAC1398       :LV::S:D::AH::::ER:::Y:::F::I:::::::::::::G::E:::::L:::::D:S
Hmu1907         ::::::ST::GQV::P:R:::Y::::::::::::::::::::SA::::::TL::::TA:S

consensus       RD----------------------------------------------------------
#oth            462222222222222212212121222222111111111111111111111111111212
HVO_1640        :S::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HQ2854A         GNSRVDPTVTNETQHVSSETIADGGANQVDTAETTTHSQSQSEYTDSAASSSSECLRESP
Hbo2355         D:EYAEREYDDGKSDGSNRTDAHGNSDDHS:::::::::::::::::::::::::::NSG
HVO_A0625       T:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG0913         DP::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
pNG6085         DS::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo3205         :Y::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hut0994         :T::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC1398       TP::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu1907         ER::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       RLVTDRSDVAFVVALLWELTFDGFVTTPAGAALIR-----PLVAV--------GIPPLLV
#oth            244427211.1123.2.21.11.113.421655541111144254123331333313554
HVO_1640        :ERLGAD::::::::::VT::::L:V:V:WGGRP:RRGSG:R::R:EPRRGLSRL:RR:P
HQ2854A         P:IE::::::VAIM:V:::::S:::::TQ:G:I:::::::TI::G::::::::::::VIT
Hbo2355         :V::GM::I:::I::V:::::S:::::QQ:VSVV::::::A::NA:::::::::L:::A:
HVO_A0625       DDL::LG:::VA:V:V:::::S:::::EQ:::AV::::::W:AG::::::::::L:::F:
VNG0913         DV::::::I:::IG:V::::YS::I::T::DTT:::::::T:T::::LPAGSTTNRAIV:
pNG6085         D:I::T::::::I::I::::YS::I::QT:::TTE:::::A::SLSNIGVGAVQ:RAI:I
Hbo3205         PKPMRDGE:::::::::VT:Y::::A:V:WQE:QA:::::SV::::::::::::::GW:L
Hut0994         D::::S:::::::::::ST:Y::L:A:::WK:::A::::::::E::::::::::V:AH:L
rrnAC1398       :::DGPDE:::::::::VT:Y::L:::::WRD:TT::::::I:DA:::::::::V::H:L
Hmu1907         :::DG:DE::::L::::VT::::::S:::WRG:AG::::::F:GL:::::::::::::G:

consensus       YGLLLLLGFAVFLGAYRLAARLSRRRSDTY---LTARALARRFAPP---------LLAIA
#oth            2364465124514332321314324454131115424522551112111111111.3111
HVO_1640        T:RENSPRNRGHVRDR::RR::V:A:VGPHRRR:PP:::P:LRRR:RARSGRGRG:A:V:
HQ2854A         :LS:FIG::IT:YA:FV::G:IASN:LL:T:::WS:DD:TVA:::S::::::::::I:::
Hbo2355         ::G:Y:::::A:F:::V::::I:AS:LQ:::::RE::E::IC::::::::::::::::::
HVO_A0625       ::::Y:G::G::::L:V::::VTA::I::F:::E:PLD::VT:::S::::::::::::::
VNG0913         :TAVF:A:Y:::::::LY:G:W:::L:G:::::::S::::V:::::::::::::::::V:
pNG6085         :T::FVS:YV::FA::WY:GV:::::TG:::::I::KRI:F::::S::::::::::::::
Hbo3205         SLAIAFV:::C::AV::V:::VA::TA::::::V::DFV::W:::A:::::::::::P::
Hut0994         :PTA:AA::GL::::::::::AA:SS:E::::::A:DR::::::::::::::::::I:::
rrnAC1398       :PVA:G::::G:::V::::V::::DM::::::::APAV::Q:::::::::::::::V:::
Hmu1907         :L:A:::::GL:WSL:L:::::::STAE:F:::::PA:::A::::::::::::::::::V

consensus       A-----------------GYHLAHYLGFFLSLA-PSLVAALTSPLSPPANPPVLSLPG--
#oth            111111111111111111.112112532212121.43573451.2331342333431211
HVO_1640        :REPLGAGRSGVVQRTPV:VRRPRPPA:GVGRPR:RVRPLSG::ATA:ERV:FRRRH:RL
HQ2854A         V::::::::::::::::::::::::V::::::S::::FD:VV::FA::S::II:T::A::
Hbo2355         :::::::::::::::::::::::::FA:::::S::::F:V:SA:F:S::::L:FT::S::
HVO_A0625       :::::::::::::::::::::::::V:::V::S::M::H::S::::S::::V::T::A::
VNG0913         :::::::::::::::::::::::::ATLAV:::::AM::VSA:::V::P::V:::P::::
pNG6085         :::::::::::::::::::::::::T:LAV::S::A:GM:IL:::::::::LT::P::::
Hbo3205         ::::::::::::::::::::::::F::Y::G::::AF::VA:A::::::AI:::A::S::
Hut0994         :::::::::::::::::::::::::::Y:::::::V:ATV:::::::::VV::F::::::
rrnAC1398       V::::::::::::::::::::F:::::Y::V::::::AV:::::FAD::VV:TID::A::
Hmu1907         :::::::::::::::::::::F::::DY::G::::::LQT:AA::TARSTVL:::I::::

consensus       -----------------------WFGALNIAFVLVGHLL---AIWVAHAAAYDLFPSRLQ
#oth            1111111111111111111111114325542212411131111212.1242143114.12
HVO_1640        HDGEPVGRRPTDGRRCRRMSRRASH:MSRE:S:V:PETAVPDGETA:TTCP:CDR:F:RE
HQ2854A         ::::::::::::::::::::::::IS:F::V:::::::I:::::::::ST::Q:::::::
Hbo2355         ::::::::::::::::::::::::VSM:::::::G::::::::::I::ST::R:::::::
HVO_A0625       ::::::::::::::::::::::::::G::V::::L::::::::V::::SQ::RT::::::
VNG0913         :::::::::::::::::::::::::N:AS:::::A::::::::V:A::T::::V::R::V
pNG6085         :::::::::::::::::::::::::EG:S::Y::I::::::::::A:::T::E::S:::V
Hbo3205         :::::::::::::::::::::::::::VQLG::VG::::::::::I::TRSF:V::G:::
Hut0994         ::::::::::::::::::::::::Y::IPV:S::A::::::::::I:::::F::::G:::
rrnAC1398       :::::::::::::::::::::::::::VAL:S:I::::V:::::::::::::::::A:::
Hmu1907         ::::::::::::::::::::::::::GVSM:SII::::::::::::::::::::::G:::

consensus       AIRSQYP--------------------------FVAVM-----VGYTMTSLWLISLPTA-
#oth            221112111111111111111111111111111.2422111113411431.122222441
HVO_1640        RL:DLHVGDAHEDLSDGETAAYEAAVEAEAEDL::YHLKVAGAL:VVF:A:F:LAVVGF:
HQ2854A         ::::::::::::::::::::::::::::::::::IF:::::::M:::IV:::::::::::
Hbo2355         :::::::::::::::::::::::::::::::::::L:::::::M:::AL:::::::::G:
HVO_A0625       :V:::F:::::::::::::::::::::::::::::::::::::IL::IL:::::::::::
VNG0913         ::K::::::::::::::::::::::::::::::::L:::::::I:::VV::::L::QG::
pNG6085         ::::::::::::::::::::::::::::::::::IG:::::::I:::VI:::IL:::G::
Hbo3205         PL:::::::::::::::::::::::::::::::::::T::::::L:::::::VVAQ:V:D
Hut0994         ::::::::::::::::::::::::::::::::::TLA:::::::A:::::::IVTQ::I:
rrnAC1398       ::::::::::::::::::::::::::::::::::I:::::::::F:::::::VV:Q:EV:
Hmu1907         ::::::::::::::::::::::::::::::::::I:::::::::V:::::::V::Q:DI:

consensus       SPPFL-
#oth            611333
HVO_1640        :L---:
HQ2854A         T:::VG
Hbo2355         ::::IS
HVO_A0625       N:::::
VNG0913         V:::VG
pNG6085         T::Y:P
Hbo3205         :L:--:
Hut0994         Q:::::
rrnAC1398       AL:H::
Hmu1907         PL:Y::