[Q] (FrnE) COG2761 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis 7 genomes BUD1280 7 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0170 rrnAC2450 HVO_2592 Hbo2258 Hmu0294 - hla0393 - HQ3211A

Pairwise sequence scores
Consensus score	1642	HQ3211A	VNG0170	hla0393	Hmu0294	HVO_2592	rrnAC2450	Hbo2258
982	HQ3211A	1641	454	954	826	870	902	856
643	VNG0170	454	929	560	560	540	546	514
1229	hla0393	954	560	1701	1051	1090	1099	1059
1288	Hmu0294	826	560	1051	1699	1157	1204	1200
1332	HVO_2592	870	540	1090	1157	1620	1233	1220
1432	rrnAC2450	902	546	1099	1204	1233	1628	1376
1374	Hbo2258	856	514	1059	1200	1220	1376	1672

227 symbols
consensus       MS-TD-AD-----AAESITVYSDYVCPFCYLGRESLRQYQETREDELEIDWHPFDLRSQK
#oth            123242222122254351322111111111111322332143122415221211111332
HQ3211A         --:--:--:::::M::::L::::::::::::::RA:ST::TE:::S:Q:E:::::::A:Q
VNG0170         --:--:--:::::-----------------------------------------------
hla0393         ::N::A::APTPD:T::::I:::::::::::::Q:FAR::::::EP:A:::::::::AG:
Hmu0294         :TD::A::RPESPTTDE:A:::::::::::::::::::F:AD:DEQ:R:::R:::::HN:
HVO_2592        --:-MSS:::::::DQA::::::::::::::::Q::S::::::DE::D::::::::::::
rrnAC2450       ::E:Q:--:::::SS:R:::F:::::::::::::::::::S:::::::V:::::::::G:
Hbo2258         ::DSES:E:::::Y::Q::::::::::::::::::::R::S:::::::::::::::::::

consensus       RNPDGSIDHSVDDGKDDEYYEQAKENVRRLQEKYDV-EMDLDLATDVDSLPAQIASYYVK
#oth            14211311332222122311211223111113412211.42124211.122..31.2222
HQ3211A         :HA::::::DAANQ:GEQ::Q::R:::::::DQ::AT::CQE:::::::R:::LV:VNIQ
VNG0170         ------------------------------------:-:ST::VG:::GFR::V::L:::
hla0393         :G:::E::DTA:::::E::::::R:::::::::::A:::AQE:R::::::::::V:VH:R
Hmu0294         :::::::::::::::::D:::::::S:::::AE:G::::S::::SE::::S::::::H::
HVO_2592        :R::::::F:::::::ED::::::QG::::::R::::::T:::G::::::::::V:::L:
rrnAC2450       :::::::::::::::::::::::::S:::::A::::::::::I:::I:::::::::::::
Hbo2258         :::::T::::::::::::::::::::::::::::G:::::::VD::I::::::M::::::

consensus       --EHADYETWLAFDEAVFAALWQDGRDIGDEDVLADLAE--DV-GLDGDEIRSALDDEAL
#oth            114222112..1..22113...2123.1.1421.221.311311121212133212.322
HQ3211A         QADAYS:DS:::::T::L::::E:D::::ETA::I:I:SEI:::DI:T:W:ETI:S:KDR
VNG0170         :::TFP-:Q::::::G::::::A:D::V::A:::::I:D::G::::::E:::TVV::::W
hla0393         :::T:P-:S:::::::I:::::::::::::RE::::I:A::::D:::PEIVDE::A:DD:
Hmu0294         ::TT:::::::D::TSI:T::::EE:::::P::::::::::RA:::::::V:A:::::T:
HVO_2592        ::G::::::::::::S::E::::::K:::::A::VE:::::S:::I::E:VA::::::T:
rrnAC2450       ::::Y:::::::::V:::E::::::Q::::::L:VE::::::A::V:::::::::A:G::
Hbo2258         ::Q:Y::::::D::V:I:D::::::A:::::EL:VK::::::A::VV::::::::::D::

consensus       RDEVRERFTAAQRAGITGVPTFAY--DGHAARGAVPPEQLERLVEGV
#oth            1321234.32.334.1......11111.21.......21.1..1223
HQ3211A         Y:ALD:Q:R:::N:::::::::VNKT::N::::::::A::R::MDN-
VNG0170         ::RL:DE:AD:RE:::::::::V::::::G:::::::S:::::::::
hla0393         ::R:TDL::::RER:V::::::::::::::::::::::::::::GD:
Hmu0294         :E::TT:::E:::E::::::::V:::::Y:::::::::::::::D:T
HVO_2592        :A::::::SE::QH:V::::::::::E:Y::::::::::::::::::
rrnAC2450       :S::::N::::K:Q::::::::::::::::::::::::::::::::S
Hbo2258         :E:::AQ::E:HQQ:V::::::::::::YG::::::::H::::::::