[S] (-) COG3403 Uncharacterized conserved protein 7 genomes BUD1282 7 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1099 rrnAC2099 HVO_2327 Hbo2011 Hmu1741 - hla1156 - HQ2279A

Pairwise sequence scores
Consensus score	2237	hla1156	VNG1099	rrnAC2099	Hmu1741	HQ2279A	HVO_2327	Hbo2011
1600	hla1156	3634	1320	1402	1304	1285	1467	1414
1638	VNG1099	1320	2274	1411	1384	1304	1431	1548
1854	rrnAC2099	1402	1411	2256	1709	1658	1484	1602
1796	Hmu1741	1304	1384	1709	2225	1741	1409	1531
1732	HQ2279A	1285	1304	1658	1741	2225	1414	1496
1687	HVO_2327	1467	1431	1484	1409	1414	2185	1562
1836	Hbo2011	1414	1548	1602	1531	1496	1562	2243

459 symbols
consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
hla1156         VEPERDRPGLVVEVDEPLLIALDDVLDRVLDLGGRVPGEVVERHLAVPTDGRSVERKPVA
VNG1099         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC2099       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu1741         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HQ2279A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_2327        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo2011         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
hla1156         HGDVRLLVERELVQPECVRAEPVRDRRLPVLRAVVVRPSVGQHVQQDDHGTVVRGGRVGF
VNG1099         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC2099       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu1741         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HQ2279A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_2327        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo2011         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       -------------------------------------------MNEPGV-GVLQDQATLA
#oth            1111111111111111111111111111111111111111111.12433115131.4123
hla1156         GIGHVCFTVLPGEKTAGAGGDGDRFPTGGDQRKPKARLFPTNR:::::TE:::L::K::H
VNG1099         :::::::::::::::::::::::::::::::::::::::::::::::EL:QAVV::Q:::
rrnAC2099       ::::::::::::::::::::::::::::::::::::::::::::TDAV:::K::::E:::
Hmu1741         ::::::::::::::::::::::::::::::::::::::::::::TDRI:::E::::::VE
HQ2279A         ::::::::::::::::::::::::::::::::::::::::::::TNCI:::N::::::VE
HVO_2327        ::::::::::::::::::::::::::::::::::::::::::::::S:H:Q::ME:DV:R
Hbo2011         ::::::::::::::::::::::::::::::::::::::::::::::::::QS:V::E:M:

consensus       ARVEAGDAPDWVRAHWETFREGLLGERNGTPFPCFFGAESVRNGDPLYTAVPSMTDKDAL
#oth            3.12412412.244.23..21321.1.112....2..111112.121.1213.21112..
hla1156         D:LD--:::G:LQD:YR::::SM::::DDS::::Y::I:VE:E::L::A:CE:T::PA::
VNG1099         D::A:::Y:::::S:::::S:SVT:D:D::::::H::::::A::E::::V:::L::P:::
rrnAC2099       ::::R::::E::G:::R::::::T:::::S::::::::::::D:E:::::::::S:P:::
Hmu1741         E::AS:ATT:::VD::T:::D::::::::::::::::::::AD:::::::::::::::::
HQ2279A         E:::S:A:::::T:::N:::D:::::::DA:::::::::::A:::::::::S:::E:N::
HVO_2327        H:LDD::L:::A:K:Y:::::TM::D:D:A::::Y::I::E::::A:::F:D::::::::
Hbo2011         ::::::EM:::AVR:F:::TDA::::::::::::::::Q:::D:E:V:::::::::::::

consensus       LDLRDTLLEYLDTYQDHSDRASLVTFFKPPERELSEADYHEALWHILQFLHVHDPEPWPE
#oth            141122.13..24141333131112.11..24222.23..12..12.21...1.12...3
hla1156         :R:::V:V::::A:A::A:::P:AV::R:::GDPG:SH:::R:::V:E:::::::::::D
VNG1099         :GF::A:::::TEHG:RDA:V:F:::W::::D:F:::::::::::::SV::::::::::A
rrnAC2099       F::GQ:::K:::::::::E::::::::R::::P:T::E::DR::::::::::::::::::
Hmu1741         :::GR:::Q::::::E::::::::A:::::::::T::Q::::::N::::::::::A::::
HQ2279A         :N:GR:::S::EI:::Y:::::::V::R::NQ::::GE::::::::::::::::TK:::K
HVO_2327        :A::::::::::V:P:Y:EAC:::::::::AADFT::::::R::::::::::N::::::A
Hbo2011         ::F::A::::::V:R:LPG:T:F::::::::::F::G::::I:::L::::::::::::::

consensus       DIPTDPDDPHWEFCFGGEPMFPTCRAPFY--DERKSRYCPVGLEITFQPRALFE--GITA
#oth            .1..11.2.31..1...1.2...2.....1123.2...1.2...1....121.12222.1
hla1156         :::::::T:RF::::::::L:::S::::::::::::::S:::::V::::::V:D:::L::
VNG1099         :V:::T:S:G:::::::::L:::::::::AAHD:Y::::::::::::::AG:::::::::
rrnAC2099       :::::::::::::::::K::::::::::::::T:::::::::::::::::::::DLNV::
Hmu1741         ::::E::::::::S:::::I:::::::::::EG:::::::::::::::::::::DM:V::
HQ2279A         :::::::::::::S::::::::::::::::::T:::::::I:::::::::::::NLRV::
HVO_2327        :::::::::T:::S:::::::::T::::::::::I:::::W::::::::::::D::::::
Hbo2011         ::::::::::::::::::::::::::::::::::::::::::::::::::T::D:::::H

consensus       DTEAGQHARETIQNRLEEYDGVCPHADLGDWGVEGDREWPQYMFSEDDDQAPDECPISIT
#oth            ..21.13..33.14.212...1.....1..1..12....2..1112.2521.21..244.
hla1156         ::::::::::::RE:MG::::::::::::::::::::::T::L:R::::AS::I::L:P:
VNG1099         ::D:::R::AA::::I:::::Q::::::::L::D:::::V::L:R:::A:::T:::ATF:
rrnAC2099       :::::::::DV::G:::::::::::::I:::::::::::::::L:S:ENAS::::::TV:
Hmu1741         :::::E:::GI::D:::G:::::::::::::::::::::::::L::::R:::S:::::T:
HQ2279A         ::AM:ER::::::D:::D::::::::::::::::E::::::::::S::K::::::::N::
HVO_2327        ::::::Q::AV::::I:::::::::::::::::::::::::::::A:ES::::::::R::
Hbo2011         ::::::K::::::S:M::::::::::::::::::S:::::::L:R::P:DS::::::V::

consensus       REHPKAPALL---------------D----ERPAASADD
#oth            .11..2453411111111111111122221455465322
hla1156         :N::::::A:LEPGAWRRLAESPAP:DDAGSVI:GTG::
VNG1099         ::::::T:GI::::::::::::::::PVVGSQ:P::G::
rrnAC2099       :::::SKW:V:::::::::::::::-:::::T::PEPA:
Hmu1741         :::::STQ::::::::::::::::::::::A:ESVGHPN
HQ2279A         ::Y::SNR::::::::::::::::::::::DENLL:PPA
HVO_2327        :::::V:TA-:::::::::::::::-::::-----P:::
Hbo2011         ::::::ASQR:::::::::::::::T::::::TPKA:::