[ER] (Tdh) COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases 7 genomes BUD1292 7 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG2617 pNG7278 HVO_B0071 - Hmu1423 Hut2561 hla0317 - HQ1124A

Pairwise sequence scores
Consensus score	2652	HVO_B0071	HQ1124A	hla0317	VNG2617	Hmu1423	pNG7278	Hut2561
2015	HVO_B0071	2649	1749	1887	1870	1734	1893	1860
2178	HQ1124A	1749	2635	1976	1967	2049	2107	2059
2309	hla0317	1887	1976	2637	2118	2024	2155	2101
2308	VNG2617	1870	1967	2118	2647	2076	2192	2087
2240	Hmu1423	1734	2049	2024	2076	2678	2169	2052
2413	pNG7278	1893	2107	2155	2192	2169	2980	2229
2305	Hut2561	1860	2059	2101	2087	2052	2229	2679

390 symbols
consensus       --------------------------------------MRAAVYRGPGDIAVEEVPRPEI
#oth            11111111111111111111111111111111111122121.114..11141.2212.31
HVO_B0071       ::::::::::::::::::::::::::::::::::::::VKS::::::::VRI::K:E::L
HQ1124A         :::::::::::::::::::::::::::::::::::::::S::::Y::R::R::N:VK:TL
hla0317         ::::::::::::::::::::::::::::::::::::::::::IFN:::::G:::R:::::
VNG2617         ::::::::::::::::::::::::::::::::::::::::::::Q:::E:::::::K:D:
Hmu1423         ::::::::::::::::::::::::::::::::::::::::::I:D:::E:S:::::::::
pNG7278         MFLYLYSIFGNCFHPITRPGGCDRRHENGFPQPTRNGS::::I:::::::T:::::::::
Hut2561         ::::::::::::::::::::::::::::::::::::MD:::::F::::E::I:D::K:AL

consensus       EAPTDAVVRVTHTAVCGSDLWFYRGDSDREEGSRVGHEPMGIVEEVGDDVTSVAPGDRVF
#oth            2412..11......1......1...4211131.21......1..1..21.3..41..1.2
HVO_B0071       QQ:::::I::::::I::::::::::HEEH::::G:::::::::::::E:::::Q:::::L
HQ1124A         :ES::::::::::::::::::::::KT::DIP::::::::::::::::::Q::DV:::::
hla0317         ::::::I:::::::I::::::::::::::D:::P:::::::::::::NE::::::::::L
VNG2617         :S:E:::I::::::::::::::::::::::A::::::::::::::::::::::::::::I
Hmu1423         :D:G::I::::::::::::::::::E::::A::::::::::V::A:::::D::R:::H::
pNG7278         :S::::I::::::::::::::::::Q::::::::::::::::::::::::R::E::::::
Hut2561         D:::::::::::::I::::::P:::QE::DVP::I::::::::::::EE:R:::::::::

consensus       APFAISCGECEFCRKGLHTSCVNGDSWG--GD-NGGAQGEYVRARHADGTLVRVPDRYAD
#oth            1..23...3..1..2.11.1.121221.112122..1.1.211332....1....112.1
HVO_B0071       V:::Y:::::::::::I::A::D:GFF:PH::ET::::A:K::VL:::::V::::E::::
HQ1124A         :::K::::M:::::R::::::::::G::::D:::::::::VI:C::::::::::::A::N
hla0317         :::::::::::::::::::::E::::::::::::::G::::::ST::::::::::::F::
VNG2617         ::::::::::::::Q::Y::::EDE:::::SEA:::G:::::KCPF::::::::::::::
Hmu1423         :::VV:::Y::Y::R::::::::::::::::::::::::::::SP:::::::::::::::
pNG7278         :::VV:::R:::::::::::::::::::::::::::G:::::::TE:::::::::::H::
Hut2561         :::VT:::::::::::::::::::GF:::::E:D:::::::::::::::::::::::H::

consensus       DEDTLESILPLTDVMGTGHHAAVSAGVEAGDTCVVVGDGAVGLCGVLAARRLGAERIIAV
#oth            .122.312.......1.......2.1131.1.21.1.............2.1..2..1.1
HVO_B0071       ::E::K:L:::::::S:::::::L:DL:::::A::I:::::::::::::K:I::::::::
HQ1124A         :DSA:R:::::::::::::::::::::S::S:::::::::::::::::::::::A::V::
hla0317         ::E::R:L:::::::::::::::N::::::S:V::I::::::::::::::::::::::::
VNG2617         :::V:::L:::::::::::::::::::GE:::A::::::::::::::::Q:::::::::M
Hmu1423         :::V:::V:::::::::::::::::::G::::::::::::::::::::::::::S::V::
pNG7278         ::::::A::::::::::::::::::::SE::::I:::::::::::::::::::::::::M
Hut2561         ::E::QA::::::::::::::::::::D::S::I:::::::::::::::::::::::::M

consensus       GHHEDRLELAEEFGATDTVSAR-GQDAVERAQELTHGGANHVLECVGAASAMETAIEVCR
#oth            ...1...21.311...1.12311.3211132311.3..11..1....111.122.2312.
HVO_B0071       ::::::::V:R:L:::::::S::::E:::EVL:::::::::::::::::::L:::AQ:A:
HQ1124A         :::P:::S::S::::::::::::::E:I:TV::M:G:::E::::::::T::::::V::::
hla0317         ::::::::::::::::E:::E:::EA::::I:::::::P:::M:::::::::N:::D:V:
VNG2617         ::::::::::A:::::::I:::::D::I:::RD:::::::::M:::::::::DS::AIA:
Hmu1423         :::P:::A::A:::::E::LGGD:T:V:D:VR:::Y:::E:::::::::::::Q:V::::
pNG7278         :::::::::::S::::E::A::::::::DA:DD::N::::::::::::::::::::D:::
Hut2561         :::::::A:::S::::::IA::::EE:::::::::Y::::::M::::STG::N:::::::

consensus       PGGTVGYVGVPHGVEDAGLDIFGMFGDNITLRGGVAPVRAYADELLADVLQGTLDPSPIF
#oth            ...11.1....1121251233143.31.23241.2....1.111.12...1.....1.11
HVO_B0071       :::SI:A:::::-::S:DF-LQPI:YK:LSFSA:G::::N:IE::MD::::::::::::L
HQ1124A         :::::::::::::LD:-:::L:SF:::::::Q::::::::::::::::::::::::A:V:
hla0317         ::::I::::::Y:::EE::NV:::::::V::A::::::::::E::M::::::::::A:V:
VNG2617         :::::::::::Y::::G:::V:T::S::::I:::::::::::E::M::::::::::::::
Hmu1423         ::::::::::::::D:::VP::D::::::A:::::::::::::D::E:::G:::::::::
pNG7278         :::::::::::::LD:S:::M:SL:::::G:N::I:::::::::::::::::::::::::
Hut2561         :::::::::::::I::D::::::L:M:::S:N::I:::::::::::::::G:::::::::

consensus       TKTVDLDGVPEGYRAMDEREAIKVLVKL--
#oth            .1..2.22131..21..1.1....1.1411
HVO_B0071       :::::::::::::Q:::D::::::M::VDE
HQ1124A         :::::::SIS:::Q:::::D::::::EI::
hla0317         :E::G::E:D::::M:::::::::::::::
VNG2617         :::::::::::::A:::D:::::::::A::
Hmu1423         ::::S:EEIAA::::::::D::::::EP::
pNG7278         ::::::N::::::Q::::::::::::::::
Hut2561         :::::::::::::::::::::::::::P::