[I] (CaiA) COG1960 Acyl-CoA dehydrogenases 7 genomes BUD1336 8 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0371 rrnAC1261 HVO_1373 HVO_A0092 Hbo0181 - - hla1768 NP4050A HQ2389A

Pairwise sequence scores
Consensus score	2918	HVO_A0092	HQ2389A	VNG0371	hla1768	HVO_1373	Hbo0181	rrnAC1261	NP4050A
1851	HVO_A0092	2896	1632	1674	1641	1692	1710	1768	1717
2220	HQ2389A	1632	2928	1928	1975	1979	2012	2036	2024
2401	VNG0371	1674	1928	3511	2164	2168	2139	2156	2106
2453	hla1768	1641	1975	2164	2906	2320	2344	2165	2120
2551	HVO_1373	1692	1979	2168	2320	2912	2514	2182	2204
2553	Hbo0181	1710	2012	2139	2344	2514	2934	2180	2158
2461	rrnAC1261	1768	2036	2156	2165	2182	2180	3007	2281
2399	NP4050A	1717	2024	2106	2120	2204	2158	2281	2955

457 symbols
consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
HVO_A0092       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HQ2389A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG0371         MRCVHEHVDVRGFRAPNHRVVQHFHVQVNPSRRHAHPFACAVLAAFGRGERVARCQGFYR
hla1768         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_1373        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo0181         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC1261       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP4050A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       ------------MDLLDDSIVPEHARDVKQEAREFAAEHIEPVAEEYYESGEYPWDVLEA
#oth            111222122222121.1333..12.232.23..2..412.2.4.23.12..1..21111.
HVO_A0092       :::::::::::::::::EAM::AN:KT::RR::T::R:N:::::GA:F::::::I:IV::
HQ2389A         :::::::::::::NI::A::::::::A:::::::::I:::::A::T:::::K:::E::::
VNG0371         TYPAAVQPRRMDVE::S:DV::::::A:::D::A::::::A:H:::::A::::::E::::
hla1768         :::::::::::::::::::::::R:::::R::::::D:Y:A:N::A::D::::::E::::
HVO_1373        :::::::::::::E:::::::::::::L::::::::EA::::::AD::::::::RE::Q:
Hbo0181         :::::::::::::::::E::::::::::::T:::::E:::R:Q:::::::::::::I:::
rrnAC1261       :::MSTQTMIIS::::SEKL:::::HE::E::::::::::::::G:::A:::::::::::
NP4050A         :::::::::::::E:::N:V:::::H:I::::::::::::A:N:AD::::::::::::::

consensus       GMDAGLVAQDISEEYGGRGFDLQQMLAIAEEFYRADAGIALTLQLASFGAEIVEDYGTDE
#oth            12212.1..1.2111..3.31.6141.23..1111..1.1.11111...2323252.244
HVO_A0092       AREEE::::E::T::::A:RS:SEAV:A::::F::::::G:A:MGQ:::TG:L:QF::PH
HQ2389A         ::S:N::::::A::::::::::P:T:::Y::L:::::S:::::::::::TD:IYKH::A:
VNG0371         A::::::::::G:D:::::L::T:::::::::F::::::::::::::::::L::E:::PA
hla1768         ::::::I::::G:::::K::::A:V::::::::::::::::::::::::C:M::Q:::::
HVO_1373        :::::::::::::::::K::::::::::S::::::::::::::::::::C::M:H::SE:
Hbo0181         :::::::::::::::::K:Y::L:I:::N::L::V::::::::M:::::C:::::::SQ:
rrnAC1261       ATE::::::::G::W::S:Y:::::::M:::L:K::::::::I::::::::::::H:A:W
NP4050A         :::::::::::::::::::L::HEI::M::::::::::::::::::::::Q:LQTH:S:D

consensus       QKERYLRPVAENDQITGLAVSEPETGSDLAGMTTTAEKDGDEWVLNGEKYWVGNAVEADW
#oth            .1133121..211111.1.1...22..111..2.2.1121111221.....1..1.....
HVO_A0092       :::T:::S:::G:A:::M:I::::::::::::E:::VR:::::::::::::I::G:::::
HQ2389A         :N:::V::::::E::::::::::DS::::::::::::::::::IV:::::::::::::::
VNG0371         ::D:L:T:::N:::L:::::::::V::N::::Q::::R::::Y::::::::I::G:::::
hla1768         :::E:::::::::::S::::::::::::::::::K:::VDGGYE:T::::::::::::::
HVO_1373        :::KW:::::::E:LS:::::::Q::::M:::E:A:::TD:GY:::::::::::::::::
Hbo0181         :::K::::::::E::S:::::::Q::::M:::::::::TD:G::::::::::::::::::
rrnAC1261       :::EF:K:::AG::L:::::::::::::::::::A:::::::::I::::::I::G:::::
NP4050A         :::TF:::::::::L::::::::D:::::T::E:::::::::::::::::::::G:::::

consensus       LTVYAKTGDT-DDRYSNYSLFIVPTDTDGYEAEHIPEKMGMRASKQGHIVLDDCRVPEEN
#oth            211.11.21412211312111211..22..31..1...1121....2..2132131.231
HVO_A0092       IL::VR:EES::KPHD:H:MV:::::S:::D:::V:::I::H::::S::TFT:::::H::
HQ2389A         ::L::::::G::T::DD:::::L:::AS::TV:::::::AY::::::::T:NQ::I:DSH
VNG0371         V::::::::::::::M:::::A::::::::::::::::::::::::A:::::::::::A:
hla1768         :::::::::S:E::::::T::::E::S:::::::::::::::::::::::FE::F:::::
HVO_1373        :::::::A:::::::::::M:::::::S::::::::::::::::::::::F:::E:::::
Hbo0181         ::::::::::::::::::TM:::E:::E::::::::::::::::::::::F:::V:::::
rrnAC1261       V:L::::::DPN:::G:::M::::::A:::H:::::::::F:::::A::::::::I::::
NP4050A         V:L::R:::NP::P:G:F:::V::::::::D:::::::::F:::::A::E:NGA:I::DH

consensus       LIGTEGGGFYMLADFFNHGRVVVGGHGLGLAAAAIEEAWEFVHDREAFGRTVSDFQAVQH
#oth            11.43.3..32111......13.11111....1.1..132...3.421135132..212.
HVO_A0092       :V:ER:N::R:V:E::::::TR:AAQ:I:::::::::::::::E::E::GP:::::S:R:
HQ2389A         :::DV:D::EIVTE:::::::D:A::::::::::::::SQ:::N:::WDQQI::::::K:
VNG0371         :::::::::M::T::::::::::A::::::::::F::::D:::::AG:::::::::S:::
hla1768         VV:S::::::V::::::::::I::::::::::::::::E::::G:N::::::NE::::::
HVO_1373        :::::::::::::::::::::I::::S::::::::::T:::::::Q::::S::E::::::
Hbo0181         V:::P::::::::::::::::::::::I::::H::::T:::::E::G:::NI::::ST::
rrnAC1261       :V:V::A::::::E:::::::::::::::::::::::::::::::::::K::DE::::::
NP4050A         :::V::A::::::E:::::::::::::::::::::::TAD:::::T::::D:AG::K:::

consensus       ILADMRMEFESARALNWRAAEKVANNENAGFWAALAKTKATETAMDCAERGMQLHGGRSV
#oth            4.12.233111..2.3121222124322213.1131.231..2.442..411211..113
HVO_A0092       D::Q::TK:::::T:L:HTV:RMESG:D:AK:SSM::LH:::::AE:::TAIR::::HGL
HQ2389A         D::E::::L::::::T::::KH:TE:N:P:Y:::::::T:::A:VN:::SA:::Y:::::
VNG0371         S:::::I::::::::AY:::::::AHDEP:L:::M:::::::V:TAN::Q:::F:::::N
hla1768         T:S:::IG:::::::::::C::::D:D:::Y::::::::S::V:T::::K::K::::::I
HVO_1373        ::::::::::A::::::::::::::G:D::::::AT:::S::::V:V:::::::::::::
Hbo0181         ::::::::::A::S:::::::::::G::::::::S::::S:::::M::::::::::::::
rrnAC1261       K::::QLSLQ:::T:T:H:::R:::Q::S:Y:::::::N:::A::::::K::::::::::
NP4050A         :::::MT::QA::T:::Q::TR:EE:D:::::::M::V:S::::N:::::::::::::::

consensus       LTENRISRVYRDVRIPVIYEGANEIQRNLIYRQSG--
#oth            13232.2.1...1.2.1....112...111.313542
HVO_A0092       FD:S::G:::::::M:L::::VS::::DI::ENF-::
HQ2389A         :K::K:::I:::::V::::::::N:::D:::K:ADWS
VNG0371         F:DR::A::::::::::::::::::::::V:::::DQ
hla1768         ::DR::A::::::::::::::::D::::::::::R::
HVO_1373        :N:YK:::::::A::::::::::::::::::::G:L:
Hbo0181         :N:YP:::::::::::::::::::::::::::::N::
rrnAC1261       :::::::::::::::::::::::D:::::::K:APM:
NP4050A         ::K::::::::::::::::::::::::::::G:GPW: