[J] (GCD14) COG2519 tRNA(1-methyladenosine) methyltransferase and related methyltransferases 7 genomes BUD1340 7 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0425 - HVO_1383 Hbo0168 Hmu0678 - hla1867 NP0356A HQ2398A

Pairwise sequence scores
Consensus score	1819	NP0356A	Hmu0678	HQ2398A	hla1867	VNG0425	HVO_1383	Hbo0168
1430	NP0356A	1870	1232	1258	1284	1281	1278	1305
1421	Hmu0678	1232	1824	1234	1293	1260	1260	1319
1430	HQ2398A	1258	1234	1862	1316	1206	1255	1347
1470	hla1867	1284	1293	1316	3302	1280	1308	1317
1431	VNG0425	1281	1260	1206	1280	1792	1325	1314
1538	HVO_1383	1278	1260	1255	1308	1325	1812	1465
1595	Hbo0168	1305	1319	1347	1317	1314	1465	1821

436 symbols
consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
NP0356A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu0678         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HQ2398A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla1867         MKPALSVAFAGSGSRVCRGEYSRATPIATSSARVATLFVSSRRIRAYVRRRRHEPAKDET
VNG0425         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_1383        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo0168         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
NP0356A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu0678         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HQ2398A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla1867         DDETDGDRRRGARRRAGRHRDGRRRRPRLRRRPGDQDGRSGSGDLPDRRVARNRRRRRCR
VNG0425         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_1383        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo0168         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
NP0356A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu0678         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HQ2398A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla1867         REPLGGRGRGRVGRRDGTRRGRDRRHPRRGCGARRRARWGPEVDGPRGLGGRRRRPRGRD
VNG0425         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_1383        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo0168         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       --------VYLLVHE--DREYLRAPGEELQTDLGVLEVPEDVEPGDTVETHLGEEFTVRE
#oth            1123322453.1122221..1.211.2123....1113.2.312.312...1124.3..1
NP0356A         ::MTRADRRV:V:RG::N::F:LE::ATQE:::::::L:::I:::T::::::D:S:E::R
Hmu0678         :::::::VT:::I::GE:::::L:A::T:E:::::::::D:P:::QI:::::D:P:::::
HQ2398A         :::MTASSS::::NDEH::::::::::::::::::::M:T::::::II::::DVA::::R
hla1867         RGSGVTDAA:::::::::::::LE::::FG:::::::::::::G:::::::::TV:E:::
VNG0425         ::::::::-M:::RG:::::F:V::::::H:::::I:A:D:PT::E::::::::P:::::
HVO_1383        :::::::::I::::G:::::::::::D::H::::M:T::::::A:Q:L:::I::::L:::
Hbo0168         ::::::::::::::::::::::::::D:::::::::T::::A::::::::::::::V::R

consensus       LRGPDLFNHLERTGAPMMPRDIGLVVGHTGVAAGDRVLDAGTGTGVLAAYLGRLGADVTT
#oth            1......1.1.......1.1.1.122.1..22311.1......1.1.1...1.2112..1
NP0356A         :::::::D::::::::::::::::::::::::::::A::::::::::::::::::VE:::
Hmu0678         :::::::::::::::::::::::I:::K::LQS::::::::::::::::::A:M:VT:::
HQ2398A         :::::::::F:::::::I::::::MI::::::R:::::::::::::::::::::::T::S
hla1867         :::::::::::::::::::::V:::M::::ASG::::::::::S:I:::::::A:::::S
VNG0425         :::::::::F:::::::::K:::::M:::::SGA:::::::::::::::::::A::::::
HVO_1383        P::::::::F::::::::::::::I:::::::::E::::::::::::S:::::::V::::
Hbo0168         ::::::::::::::::::::::::I:::::A::::::::::::::::S:::::MH:E:::

consensus       YERDPEFADVARENMRLAGVEDRVDVRTGDVTEELDALADEGPFDVLTLDTGDAPEVVAH
#oth            1.2.21..2...1..42...323.3.12..21333.3112412..22....21.121122
NP0356A         ::::::::E::::::ET:::A:N:T:E:::IAATI:D:--K::::LI::::::::::::Q
Hmu0678         :::::::::::::::AM::::::::::S:::::AV::::ETD-:::V:::::::AA::ER
HQ2398A         ::I::::::::::::S::::T:A:E:::::L:VAF:TV:::::::::::::::::AIIEQ
hla1867         ::I:S:::E:::G::VT:::A:::E:::::L::::::::::D::::::::::::::::ER
VNG0425         ::Q:AD::A::::::S::::S:A:S::A::::AD::::---:T::::::::Q:::D::::
HVO_1383        F:::A::::::::::::::::Q::::::::I:D:::D:::S:-::A:::::EN:::::R:
Hbo0168         :::::D:::::::::::::::EY::::A::::::::SV:E:::::L::::::::AD::::

consensus       ADDLLASGGYVAVYSPFVENARAAVEAAREAGLRDVETLETIQREMDFDDRGSRPSTAGV
#oth            .22..22..22.1.1..1.42.23321..1..2632213.....31.141..1....1..
NP0356A         :::::::::FI:T::::::T:::CA::::::::D::::::::::::::::::::::::::
Hmu0678         :PE::VP::FL::::::::Q::E:IQT::D:::::A::::::::AL:VS:::T::::R::
HQ2398A         :QT:::::::I:::V::I:HT:DV::::::::VGAIK:Y:::::::::GE::::::::::
hla1867         ::::::P:::L::::::::GT:E:AL::::::FEG:::::::::::::S:::::::::::
VNG0425         :::::V:::Q:::::::::::::TTQ:::D:::V:IDAM:::::R:::::::::::::::
HVO_1383        :P:::VT::::::::::::GT::::::::::::S::::F:::::Q:::N:::::::::::
Hbo0168         :PE::R::::::::::::::S::::::::::::NE:::F:::::R:::EE::::::::::

consensus       GHTGYLTFARNE----
#oth            ......211.421111
NP0356A         ::::::::::FLPSLE
Hmu0678         :::::::::::P::::
HQ2398A         :::::::IG:I:::::
hla1867         ::::::V:G:AP::::
VNG0425         ::::::L::::P::::
HVO_1383        ::::::V:::::::::
Hbo0168         ::::::V:::Y:::::