6 genomes BUD1422 7 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi - rrnAC1195 HVO_2655 HVO_B0161 Hbo3766 Hmu1388 Hut0704 hla1916 - -

Pairwise sequence scores
Consensus score	1711	HVO_2655	hla1916	Hut0704	HVO_B0161	Hbo3766	rrnAC1195	Hmu1388
696	HVO_2655	1655	586	597	635	644	530	627
1210	hla1916	586	1837	1013	1057	1090	1055	1053
1248	Hut0704	597	1013	1644	1073	1129	1045	1150
1385	HVO_B0161	635	1057	1073	1686	1361	1080	1220
1347	Hbo3766	644	1090	1129	1361	1703	1083	1143
1284	rrnAC1195	530	1055	1045	1080	1083	1708	1270
1432	Hmu1388	627	1053	1150	1220	1143	1270	1670

248 symbols
consensus       -MLDY-PKPDDD---------DDEQCDDCPDD----G-GAVQPSIF----SDDRAELQRR
#oth            1453513544221111111113425444122311123344551222111151311315..
HVO_2655        ::SKR:TTNT:T:::::::::ETDTDT:A::I::::-:--------::::PQSDD::T::
hla1916         MGD:A:TD:RQTRAGTDTHLG:R:L::A::EN:::DDGL::D:::YRPFWK:A::::K::
Hut0704         :----:------:::::::::---VS:E::C:HDGEAS:P:R::L:::::D:::::::::
HVO_B0161       MR::N:QHAS:::::::::::C::H:A::G::::::-:SNH::::::::::::::S:A::
Hbo3766         MT:GSG:SDS:T:::::::::CEDC:SS:::::::::::GFH::::::::::N::AVE::
rrnAC1195       ::I:::::::::::::::::::E::G:::SC::::::ATGTS:TLY::::G:A::::R::
Hmu1388         :-M:::::::::::::::::G::::---::CA::::::S:S:::::::::T::::Q::::

consensus       DYAKLLATVGGLTAVASLAAPLA-GLTRVFERGYTGPVYSDGIPLVDGDGERITE-DALS
#oth            13..2..23..21121.13112.111221121314112.31114...22.1123213112
HVO_2655        NM:::::GI::AA:IG:FGVDY:A::PGSLDT:-NETL:VE:TR:::R::NPL:AA::::
hla1916         ::::V::::::I:::G::V::V::::::::DTK:R::::E:::::::DA::::A:::RIA
Hut0704         :I::::::A::::GL:::::::::::QQ::Q:T::::I:GES::::::E:N:::P::R:E
HVO_B0161       :::::::S::::::::::::::::::::::::S::::::::::Y:::::::::G::N:::
Hbo3766         :::::::::::::::G::T:::::::::::::S::::::::::Y::::E:::VS::S::A
rrnAC1195       :F::F:::::::::::::T:::::ST:Q::::::K::::::::H::::E:::::::GR::
Hmu1388         :F::V:::T::::::::::::::::::Q::::::S::I:::::N::::::N:V:::S:::

consensus       EGE--QMTVFPEPRPG----IEDAPTLLVRFAEDAYGGDTNLEYTVDGYAAYSKVCTHAG
#oth            31.11211....111.1111122.1...1.23132.23424422.15..1.1..1...1.
HVO_2655        TD:FDK:D::::KEG:GALVTKR:T:::L::P::E:EAP::I:G:AK::V::::::::E:
hla1916         P:::::L::::::::::::::::::::::::E:S:::DEVRD::::G::::F::::::::
Hut0704         ::::::L::::::::::::::G:::::::::P:TE:::G:E:A:::::::::::I:::::
HVO_B0161       :::::K::::::::::::::::K:::::::H:::::::A:::::::S:::::::::::::
Hbo3766         :::::K::::::::::::::::R:::::::H:KE::S:G:K:::::A:::::::::::::
rrnAC1195       :::::H::::::::::::::::::::::::Y::SD::S:ISEGF::N::::F::::::::
Hmu1388         A::::::::::::::::::::::::::::::S::D::::::MAF::::::::::::::::

consensus       CMVSNREGDTLVCPCHFGKFDPTAGAAVTGGPPPRALPQLPITLSSE---GYLIATGDFE
#oth            .2.122214411....31211125.13.21..12.2.....11222111115.2...1.3
HVO_2655        :L:AGDQ:SE:R::::GSLY:::K::S:::::AS:S:::::LGIADDEDGTL:L:::P::
hla1916         :::AD:D::V::::::S:R:::VT:GQ:V:::A::::::::::::GD::::::V:::::Q
Hut0704         :T::D:::E:::::::Y::::::N:::::::::::P::::::::A::::::H:::::::D
HVO_B0161       :::::ED:A:::::::::::::::::K:V::::S:::::::::::::::::N:::::::N
Hbo3766         :::::E::E:::::::::::::::::K:V::::::P::::::::::::::::::::::::
rrnAC1195       ::::D::E:LV:::::::::NVLE::::S::::G:P:::::::MT:D::::F:V::::::
Hmu1388         ::::::::NA::::::::::::LS:::::D:::G:::::::::MT::::::E:V::::::

consensus       GPVGPGGE
#oth            .21.2112
HVO_2655        ::I:TEE-
hla1916         ::I:::::
Hut0704         :H::A:::
HVO_B0161       ::::::::
Hbo3766         ::::A:::
rrnAC1195       :::::::G
Hmu1388         :T::::::