6 genomes BUD1437 6 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi - rrnAC1206 HVO_B0169 Hbo3565 Hmu1396 Hut0712 hla2044 - -

Pairwise sequence scores
Consensus score	2062	Hut0712	hla2044	rrnAC1206	Hmu1396	HVO_B0169	Hbo3565
901	Hut0712	2009	706	712	727	753	796
1358	hla2044	706	4657	1110	1100	1134	1096
1638	rrnAC1206	712	1110	2132	1740	1181	1190
1595	Hmu1396	727	1100	1740	2157	1196	1193
1484	HVO_B0169	753	1134	1181	1196	2056	1529
1508	Hbo3565	796	1096	1190	1193	1529	2066

614 symbols
consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
Hut0712         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla2044         VIASTRSLTVRTETGPTEVVCREFADETRDCASDLTAVPRSLRRSRGLGRPARRRRRRGR
rrnAC1206       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu1396         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_B0169       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo3565         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       -----------------------CRDD---------------------------------
#oth            111111111111111111112323212111111111111111111111111111111111
Hut0712         :::::::::::::::::::::MPE::G:::::::::::::::::::::::::::::::::
hla2044         DRDPRAVQRAVRAGRVPAPTGPG:::GRGARVRGRARGRRALDGASRRSRRTPVRRGVRR
rrnAC1206       ::::::::::::::::::::MTG:H:::::::::::::::::::::::::::::::::::
Hmu1396         :::::::::::::::::::::::-MT::::::::::::::::::::::::::::::::::
HVO_B0169       :::::::::::::::::::::::V::E:::::::::::::::::::::::::::::::::
Hbo3565         :::::::::::::::::::::::V::E:::::::::::::::::::::::::::::::::

consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
Hut0712         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla2044         ARDGLRCGDGRCGRRDSGRRGARVRPRNGAARNLLRASTGRHRADVRARRRALARRDGRT
rrnAC1206       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu1396         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_B0169       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo3565         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
Hut0712         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla2044         RWVPLPSGRIRRVPRGGDPPRGSGRGRPGRPRCRRTRVRGGRRRERRRAVRYRERAARRI
rrnAC1206       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu1396         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_B0169       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo3565         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
Hut0712         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla2044         RRRREPAPARRDRRVRRGRCRRFRVPRRRRAARDRRGPPASRGRPRDAGGRDRRLSRRGA
rrnAC1206       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hmu1396         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_B0169       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
Hbo3565         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       ---------------------------DE---ATDGPPDPQLDPERSPGLGADIDGLEDI
#oth            111111111111111111111111111222222222321.12111411113323421211
Hut0712         ::::::::::::::::::::::::::::H:::-----RS::A:-----D:AEREGNHPEV
hla2044         RGARRGRVLREGGRAGRTERYRGEYPMRDPDE:::::T::RVH::E:::F:EEP::::::
rrnAC1206       :::::::::::::::::::::::::::::FEKHLEED:::::::::::::HT::EA::::
Hmu1396         :::::::::::::::::::::::::::::FEKHLEEE:::::::::::::H::::A::::
HVO_B0169       :::::::::::::::::::::::::::E::::::::::::::H::Q:::F:V:PV:::::
Hbo3565         ::::::::::::::::::::::::::::::::::::::::::H::N:::FD::TS::A::

consensus       EVSR-DVTIGEASPAELAASDTEPVEDDAVADLLADLAADAAVERRRAALALAERAPTEA
#oth            111.2...1.2.122112.2..2.12233323112214313421.1....1.32134224
Hut0712         TT::A:::L:Q::E:DF::A::D::A:ESECA::DR:D::::T::Q:::::::G:D:G::
hla2044         ::::::::::D:::R::Q:T::A:LRGTDA:EKI:::VDGDP::::::::::G:GR::::
rrnAC1206       ::::E:::::::T:E::::::::::A:::::S::S:IEHG:KTD::::::E:KD::S:DE
Hmu1396         ::::A:::::::T::::::A::::::G:DPSE::::::::SEID::::::::KD::T::T
HVO_B0169       ::D:::::::::TL:D:G:::::::::HP:S::::S::G:G::::::::::::::EGDRV
Hbo3565         ::D:::::::D::L::::::::::::S:::::::SS:SG:DV::::::::::S::ER:DP

consensus       IVAALARAATTDDDADVRQFAVEALAAHG---------GERAAEAAVALLDDPDPWVRAE
#oth            3231.242223.3122.......1.22111111111111241212123132.11....1.
Hut0712         AID:::DRTRD:PE:T:::::::::GELA:::::::::-:SMP::VRSATE:::::::::
hla2044         SLD::IEYGLA::::::::::::::GEL::::::::::::::G:::::AC::::::::::
rrnAC1206       ::::::::::::::S::::::::::T:::::::::::::::::AV::E::G::N::::::
Hmu1396         :::G::Y:::N:P:D::::::::::T:::TDAGSGTET::A::AV::E::::::::::S:
HVO_B0169       V:E::S::::::E::E::::::::::K::::::::::::DL:::T:R::T::::::::::
Hbo3565         ::QG::H:::::A::::::::::S::KL:::::::::::PV:::T:SV:V::E:::::::

consensus       AVVALDRLDREAHADRIEAALDDDHHAVRRNAAISLFKLRGEAAADELLELSDDDSERVR
#oth            .1.2..221.22.133123.1..2...11...31..1.2...23223.1322212.1.1.
Hut0712         :I::::H::::G:::::VD::::E::::::::V:::W:G:::DVLP:::G:V::E:D:::
hla2044         :::::::IG:SE::PT::T:::::::::V:::MV:::::::::LCSV:::::HA::::L:
rrnAC1206       :::T::NV:::::E:D:A::I::::::::::::::::::::::M::L:::Q:H:::::::
Hmu1396         ::::::N::::::ESDL:T::::::::::::::::::::::::M::L:::Q:R:::::::
HVO_B0169       ::::::::::GE:EAV:::::::E:::A::::LV::::::::G:C:A:VAAA::P:::::
Hbo3565         :::S::::::G:::::::G::::A:::A::::::::::H:::D:LP:::D:A::P:::::

consensus       EWAAHLLGGVDDDRARERLRRLA-DDEAS-VVRQTAVRALDVDPGRFRRQFGGALENDDR
#oth            ..1111.1113321.422.431231123211.13..2112221313111113.2122232
Hut0712         ::V:E:::RIGHPD:EDA:TQ:RA:::S-:I:AK::AN::--:G:DSIPGPP:GTAP:GT
hla2044         :::V:::A::::E::TS::DAV:N:ETQ:K:::S:::::::A:::K:::::S:GT:::SA
rrnAC1206       :::::M:::::E::::::::E:T:::P:T:::::::E:S:::::::::::::::::::A:
Hmu1396         :::::M:::::E::::D:::E:T:::P:T:::::::E:::E:E:R:::::::::::::S:
HVO_B0169       ::::::::::ET:::A:A:S:::::::Q:::::E:::::QE::S:S:::::T:V:DET::
Hbo3565         :::::::::IA::::H:T:E:::EE::R:::::E:::::R:::A:S:::::S:::DES::

consensus       DLPGEDRLNRMPDL
#oth            211.12211.3.2.
Hut0712         :PS:--TRD:S:Q:
hla2044         :::::ST:::R:::
rrnAC1206       L:::::::::::::
Hmu1396         L:::::::::::::
HVO_B0169       T:::::D:::T:N:
Hbo3565         T:::::D:::T:::