[V] (CcmA) COG1131 ABC-type multidrug transport system, ATPase component 5 genomes BUD1647 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0470 VNG1893 VNG6326 rrnAC2073 HVO_B0134 - Hmu3183 Hut0808 Hut1599 Hut2330 - - -

Pairwise sequence scores
Consensus score	1891	HVO_B0134	Hmu3183	Hut2330	Hut0808	Hut1599	VNG0470	VNG6326	VNG1893	rrnAC2073
1270	HVO_B0134	1914	995	1091	1041	967	988	1074	1124	1045
1290	Hmu3183	995	1878	1323	1004	1048	980	1017	1073	1115
1253	Hut2330	1091	1323	1901	1038	901	942	1017	1072	1045
1374	Hut0808	1041	1004	1038	1997	1026	1124	1113	1198	1077
1280	Hut1599	967	1048	901	1026	1843	1048	1071	1111	1156
1371	VNG0470	988	980	942	1124	1048	1878	1095	1225	1153
1370	VNG6326	1074	1017	1017	1113	1071	1095	1967	1214	1193
1469	VNG1893	1124	1073	1072	1198	1111	1225	1214	1853	1212
1347	rrnAC2073	1045	1115	1045	1077	1156	1153	1193	1212	1837

271 symbols
consensus       --------MMDDPAIEADDLTKRYGDTVAVDDLDLAVPSGSVYGFLGPNGAGKTTTMRML
#oth            1111122336545.1413412.311433.25333.3125.4.1.......1...1.1.2.
HVO_B0134       :::::MPSTNA:A:V::T::R:A::SE::L:GVS:SI:::T:::::::::::::::::I:
Hmu3183         :::::::::TVS:::AT:G:S::::S:T::A::::T::::V:::::::::::::::::::
Hut2330         :::::::MTG:TS::T:REI:::::N:::::G:N:D::T:V:::::::::::::::::I:
Hut0808         MGGTEVNETDSTF::::T::::HF::V:::Q:::::IEP:T:::::::::S:::::::::
Hut1599         :::::::::S:T:::AT:S:R:E::TA:::R::::T:SH:E:F:::::::::::S:I:::
VNG0470         ::::::::-:T:L::R::G:::::::EA::::::::::A:::::::::::::::::::L:
VNG6326         :::::::::T:HL::TT:::::E::::T::SGFT::IEA:H:::::::::::::::I:::
VNG1893         ::::::::-:T:R::::RA::::::::T:IERI:::::::::::::::::::::::::::
rrnAC2073       :::::::MCPPA:::VTEG:::::SGVS:IES:::T::R:::F:::::::::::S:I:I:

consensus       TTLTEPTSGTARVAGVPITDRAALVPHIGYLPEEPPLYDELTGREQLRYVAGLRDIPDEE
#oth            .3.44.12.42412.43442.5623221.2..13..224.1112.2.42313.1244664
HVO_B0134       :G:SQ::::SV:IC:LDAS::GK:A::V:::::T::::::FSA::::D:::D::::SS:T
Hmu3183         :G:V::SE:::T:::::SD::RQ::DR::L::::::::E::::::::EFA:D::RV:F:Q
Hut2330         :G:I:::::DGF:D:IDCS::GD::D:::L::::::::R::::::::HFA:D::GV:W:R
Hut0808         ::::R::::E::I::I:::::NGVIE:V:::::::::F::::AG:Y::H::A:H:::GD:
Hut1599         :::Q:::::::T:::ES:QR:ERVT:R:::::::::V:P::::::N:Q::::::GVA---
VNG0470         :S::D::A:::E:::::V::::::T:R:::::AD::VF:::::W::::H::R:HGLD:G:
VNG6326         :A:::::::AGH:::H:::N:Q:II::::::::L::I:::::A::::E:HG::::MDPV:
VNG1893         :::V:::::::T::::EV::::SV::N::::::::::HA:::A::::::I::::::::PR
rrnAC2073       ::::N::::::::::ESVA::::V:E:::F:::::::::::::::::E::::::GHE:W-

consensus       AEDRIEDLLDRFDLAEDADRRISGYSKGMKQKTGLVQAMLHDPDVLFLDEPTSGLDPRAA
#oth            334.244221212.6311121142..1..21.21312133.1.3.12.....1.......
HVO_B0134       ::A::D::::Q:::VG::NK::GT:::::::::AFI:SV:::::::::::::::::::::
Hmu3183         IA::ALG:C::LG:G::L:::VD::::::R:::AF:::VQ:::S:V::::::::::::::
Hut2330         V:::AL:IA:SL::QA:L::::D::::::::::AFI::VQ:::G:V::::::::::::::
Hut0808         :DE::A:Y::::::::A:::::::::T::R::::::G:I::E:S::L:::::::::::::
Hut1599         :D::::T::E::G:::A:N:AVA:::::::::L::IG::V:E:E::::::::A:::::::
VNG0470         :DT:::S::E::::LA::::::ES::T::TK:V:V:A:::::::::::::::::::::::
VNG6326         I:::::E:::::::TG:::D:::T::::::::::::::LM:E:::VI:::::::::::::
VNG1893         ::Q::T:::E::S:GD:::::::T::::::::::II::::::::::::::::::::::::
rrnAC2073       --::V:S:::::::DG:::::VET::::::::L:::::L:::::::::::::::::::::

consensus       RTVRDTIAELAAGDTTVFLSTHILPVVEELADRVGVLYDGRLVAEGPPEELKSRAEEGGE
#oth            112122141123423.11....1.1..2221131.114..51.21.4.341444344254
HVO_B0134       :QI:TS:GDV:DSGA:::::::::::::AV::E::::F:::V::::T:D:V::::QT:::
Hmu3183         K:L:EL:V::::D::::::::::::::::I:::::::H::::::::::G::IGSV:TE:G
Hut2330         K:L:EL:V:::S:::::::::::::::::I:::::::::::::S::S:GG:AAA:D:D::
Hut0808         :::K:L:::::::E::I:::::::S:::::::V::::H::::::::S:AA::QQ::::TG
Hut1599         :::K::::DVSERGV:::::::::::::::G::::::Q::Q::::::::D:G::L--:ED
VNG0470         ::::::V:D:S:::A::L::::V::::D::::TI::ID::V:::D:D::N:::T:R::SA
VNG6326         :::::::T::::::R::::::::::::A:::TE::I::::E:::::A:::::D:M:A:::
VNG1893         ::::::::D:T:::A::::::::::::DD:::T:::::::S::T::::DA::Q:::A:D:
rrnAC2073       :::::::S:V::A:::::::::::::::::::T:::::::D:::::S::::TGSV:S:--

consensus       ADLEDVFLAVT---------AEADAAAAGE-
#oth            42..11.141.21222122344347485444
HVO_B0134       GS:::A:::::::::::::SD:PQLSG:TDE
Hmu3183         :::::A:::L::::::::::GD:SE:Y:T::
Hut2330         :::::A::EL::::::::::::PER:WQ--:
Hut0808         DT:::::::::ADHTEEYAS::PE:::D:A:
Hut1599         ::::::::N::::::::::RSR:SVGTV::Q
VNG0470         ::::T::ME::::::::::::D:::PLPDS:
VNG6326         ST::::::E::TDEAYEADESPS:TGVSRSA
VNG1893         RT::::::T:::::::::::----GGID:AA
rrnAC2073       ST::::::D:::::::::::----SEHP::R