[K] (-) COG1695 Predicted transcriptional regulators 5 genomes BUD1731 8 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG5028 VNG6027 VNG6239 rrnAC2270 - Hbo3073 Hmu0099 - - NP3776A NP4444A -

Pairwise sequence scores
Consensus score	1325	VNG6239	VNG5028	VNG6027	Hbo3073	rrnAC2270	Hmu0099	NP3776A	NP4444A
740	VNG6239	1453	704	704	590	234	254	232	246
1049	VNG5028	704	1431	1431	772	296	321	268	274
1049	VNG6027	704	1431	1431	772	296	321	268	274
758	Hbo3073	590	772	772	1419	200	239	231	229
483	rrnAC2270	234	296	296	200	1226	690	333	434
513	Hmu0099	254	321	321	239	690	1237	416	438
435	NP3776A	232	268	268	231	333	416	1210	474
477	NP4444A	246	274	274	229	434	438	474	1203

198 symbols
consensus       --MDDLLEELTADID----NAEADFAVTDLELGAESDGTSDHADQPP-------Y--TPL
#oth            123342353333443211153453343343435433133434433334433333122344
VNG6239         :::::::A::KSEM:AAGVD:DVE:SLPT:::T:AL:A:I:DTS:LYTDDPPHH:TD:::
VNG5028         :::::::::::::::A:::::AIS:::::::SVI::::A::::::::DEGATQR:TD:::
VNG6027         :::::::::::::::A:::::AIS:::::::SVI::::A::::::::DEGATQR:TD:::
Hbo3073         :::ER:AK::HEE:RM:::ET:LS:T:SAVRSLLA:EYEPK:GS:FGESSSSPQ:ME:Q:
rrnAC2270       MSG:N:RRVT:GKMQ::::GRN::ER::P:-----G:TERPESHD::SR:::::-::DAI
Hmu0099         MTE:E:RHVP:G:AG::::H:S::ERL:P:VG:RDTETS::RSSR--:::::::-::DGV
NP3776A         :::TEM--DP::QLG::::S::S:QSI:VSQ:R::L:::GQSEAP--:::::::-::GTA
NP4444A         ::--------MSSQG:::::V:PTLERLVT:::-DG:A:R:D::P--:::::::-::AAR

consensus       TDDAVATMDGWLDDGQLHTVDDGIVTQSLDEILLLLIAVRDGACHGKELLQDLRRLFGAD
#oth            234314434331333433423143133312.2..31122234311.1211211324.123
VNG6239         :G:DLPLLEA::::A:::G:G:D:IAEYI::V::V::T::G:::-:::::::V:::::::
VNG5028         :::::::::::::ND::::IS:A:::EHI::::::::T::::::-:::::::::::::::
VNG6027         :::::::::::::ND::::IS:A:::EHI::::::::T::::::-:::::::::::::::
Hbo3073         :::::::::::::EAY::::S:KD:IAQ::::::::::::GE::-:::::::::::::V:
rrnAC2270       :ESLLDPVIDDVV::ET-A::::L:::::E::::AM:::A::GT::TG:MEE:EAQ:::E
Hmu0099         PETLLSSVGET:A::DA-AI:E:L::::::::::A:::SSTDQT::T::MDE:E:C:D:Q
NP3776A         ISEV:DEVEAS:FGTDGFSFEETH:KS::::L::S:V:L:SSDT:::Q::D::AQE:DTI
NP4444A         :EAV:TEASET:FE:GTLH::::LIK:::P:L::::VGL:STDT:::GIME::S:F:::Q

consensus       LSPGTVYPHLHDLADEGLLEMRELVKRKVYRIADAEAAFERIDHAVDQHLAFGLVLKAAL
#oth            1....1..2.22.33213.2241.211.3.322.34224551363251112222214242
VNG6239         V::::M::::KQ:::A:::::S::T::::::V:::Q::I:HV:SV:L:L:T:AVG:QTIM
VNG5028         ::::::::::N:::V::V::VQK:S::::::LS:P:G::T::::M:::L:L:S:::::VM
VNG6027         ::::::::::N:::V::V::VQK:S::::::LS:P:G::T::::M:::L:L:S:::::VM
Hbo3073         ::::::::::N::::::M:D:T::T:::I::::::::T:NSVEP::NRLIT:S:::::LI
rrnAC2270       ::::::::R::E:EAD:T:Q:H:::QT:Q:G:::DA::K:Q:ATSAY::::L::F:H:S:
Hmu0099         ::::::::R::E:DS::::::H:::QT:Q:S:S:DP::RD::ER::Y::::I:MF:H:S:
NP3776A         ::::::::R::::C::DV::Q:::::T:E:TLD::TE:QSD:AE:AR::::L:M::R:::
NP4444A         ::::::::M::::EADD::::::::QT:E:T:D:T::VRGE:QA:MQ::::L:::FSR::

consensus       DDCKARQSQS--------
#oth            424344333223322321
VNG6239         A::IVN::ADPQPQDE::
VNG5028         T:::::::::QGRETND:
VNG6027         T:::::::::QGRETND:
Hbo3073         I:::T:HV::QRSETDER
rrnAC2270       :AL-------::::::::
Hmu0099         ::A-------::::::::
NP3776A         EEGDFE----::::::::
NP4444A         :EIDVDEMDD::::::::