[R] (GloB) COG0491 Zn-dependent hydrolases, including glyoxylases 5 genomes BUD1757 5 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1340 rrnAC1263 HVO_1368 - - - hla0572 NP3970A -

Pairwise sequence scores
Consensus score	2124	rrnAC1263	HVO_1368	hla0572	VNG1340	NP3970A
1408	rrnAC1263	2376	1265	999	1063	1007
1500	HVO_1368	1265	2135	1136	1021	1138
1386	hla0572	999	1136	2163	955	1163
1375	VNG1340	1063	1021	955	2380	1102
1560	NP3970A	1007	1138	1163	1102	2127

303 symbols
consensus       --------------------------------MVDADVHLIDRGRIRADRNYMIDGHSMA
#oth            12221222222222222222222222212222132331132...2242.32223123231
rrnAC1263       MKPHSTAKCGWCTEPAHCARHRLYFVTGRRHC:D:LT:TF:::::VQ::::FVV::::V:
HVO_1368        :::::::::::::::::::::::::::::::::G:IS:::V::::VH::TG:VL::Y::G
hla0572         ::::::::::::::::::::::::::::::::::N:E::V::::GLYC:M:::MEANTIG
VNG1340         MVVASPPPRINLCQRLTTTGRFPRPNFGAATSPPGV:::YL:::T:T:::A::::SST::
NP3970A         :::::::::::::::::::::::::::::::::::::I::L:::T::T:S:HI:E::IT:

consensus       SADNPNPDHELVECPVWNLLIDHPEGTVLWDTGSHPDAGDGYWPDPLYEAFAHADAAEHT
#oth            122312.12123241.1.12112.23.1......112.1..1..22.22..414..2113
rrnAC1263       T:SHRD:E::YETYV::::I:ET::L::::::::::E:::::::T::::::::T:::::A
HVO_1368        ::S:::::::MS:FV:::AVV:G:DR::::::::N:A:A::::::::::::S:V:::D::
hla0572         :H:E::::T:YD:I:::::V:::::A:I:::::::H::A::H::EG:VQ::YPH::SD:R
VNG1340         TVAD:D:E:A::::::Y:::::::K:::::::::::::::::::T::F:::H:E::D:::
NP3970A         :::::H::VA::DG::Y::::::::::I::::::::E::::H:::E::A::E::::D:RD

consensus       LDADLEAAGYSIDDIDAVVQSHLHLDHAGGLRRFAGTDVPIYVHEEELKYAYYSAKTDEG
#oth            .221.221.13321..1.12...........34..1..1.11..12..21..1..2.13.
rrnAC1263       :P::::D::::::E:::::M::::::::::::N:::::::::::R:::P::::::N::D:
HVO_1368        :ED::G:V::DPA::::::M:::::::::::VE::::::::::::::::F:::::::T::
hla0572         ::D::::::::L::::::F::::::::::::EF:::::T:V::::::::F::::::::::
VNG1340         :P:A:AD::TA:S::::::A::::::::::::H:::::T::::::R::G:::R::A::T:
NP3970A         ::TA:GEV::TV::::Y::::::::::::::Y:::D::::VF:::A::::::::::::A:

consensus       SIAYLADDFDHDLNWEV--VHRDRETLFDGIELLHLPGHTPGLLGAHIDLDD-EGRVLVA
#oth            .2..222...12...311111113332231221111......12.241232112242222
rrnAC1263       ::::::S:::R:::::I::::G:SYH:T:::::::::::::::M::F::RP::-QSL::V
HVO_1368        ::::::S::::::::H:::::G:EH:::::FR:V::::::::V:::::ETP::-:D::::
hla0572         :A::VL:::::::::Q:::L:::::ER:TDL:FVRF:::::::T:SV:H::S:::T:VFT
VNG1340         ::::HSP:::RA:::R:VA:D:G:RQ:YP:LD:::::::::::::LYLEPE:GAAPAI::
NP3970A         :T:::::::::N::::I::::::G::H:ED::F::::::::::::LS:::::::::::I:

consensus       GDEAYVRENYEDGQPLGTGLLWSKRDWAESLRRIRELQRRTDADVLCGHDLADFEALADG
#oth            ..13.323.12212.1132.112332.41.23222112.11222122...2432143333
rrnAC1263       ::::::EA::A-:::MA:S:::NNGA:K:::E:C:DR::A:G:E::L::::GV::DV:GA
HVO_1368        :::C::EG::T:EV:::P:::::E:::F:::QTVK::E:::GG:::F:::::R::SFG::
hla0572         ::QV:MD::::E:T:::GP:V:G:TE::::MN:::::E::H::EIVF:::PEQ:::IQP:
VNG1340         :::::Q:::::::V:MA:S::S:LA::R::R::V:D:A:::T:::F::::TR:AAR::AR
NP3970A         :::F:T:T:F::E::::A:::::::::YD:::K:Q:R:::H:VR:F::::PV:VAT:R:E

consensus       FA-
#oth            241
rrnAC1263       TD:
HVO_1368        WNV
hla0572         WGV
VNG1340         :-:
NP3970A         :::