[L] (RFA1) COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins 5 genomes BUD1819 8 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG5194 VNG6403 pNG6120 HVO_A0019 HVO_A0374 HVO_A0409 - - Hut2396 - - HQ3584A

Pairwise sequence scores
Consensus score	2256	pNG6120	Hut2396	HQ3584A	HVO_A0409	VNG6403	HVO_A0374	HVO_A0019	VNG5194
1267	pNG6120	2327	1410	1292	1034	1189	1158	1195	1166
1233	Hut2396	1410	2153	1236	991	1155	1106	1148	1094
1424	HQ3584A	1292	1236	2414	1108	1239	1248	1405	1317
1719	HVO_A0409	1034	991	1108	2155	1570	1603	1660	1607
1906	VNG6403	1189	1155	1239	1570	2256	1907	1778	1855
1992	HVO_A0374	1158	1106	1248	1603	1907	2271	1924	1996
2066	HVO_A0019	1195	1148	1405	1660	1778	1924	2261	1972
2054	VNG5194	1166	1094	1317	1607	1855	1996	1972	2480

333 symbols
consensus       ------------------------------PMSSNNASGNVVSVDEQAFEKA-DEAAVDE
#oth            1211111122212333333233333333431112224243212.11..1142123332..
pNG6120         ML:::::::::::GASRWRRTSAFSGIWRI::::::S:RK::T:::::::RT:ED:G:::
Hut2396         ::::::::::::::::::::::::::::::-::GKQL:T:E::::A::L:PTRERSGS::
HQ3584A         MVLSVVVVEEIRDVGASRCRARERLQVWLR:::::::TS::::::::::::H::::E:::
HVO_A0409       ::::::::::::::::::::::::::::::-------------:A:::::Q::::TT:::
VNG6403         ::::::::::::::::::::::::::::::-:::::VTTD::::::::::N::GGQ::::
HVO_A0374       ::::::::::::::::::::::::::::VI:::::::::K::T::::::D:::GGQ::::
HVO_A0019       :::::::::::::::::::::::::::MVR:::::::TS:::::::::::::::::::::
VNG5194         MVLSVVVVGKPRCRSIAVAARERLHRYGEY:::::::::K::::::::::N::G:Q:A::

consensus       DGFEVVDETPEFRATVQQETQAKVDANHPDGIVDTSDDRIHGVTLEQEERIRAREAELER
#oth            1.12..111.2.213.21.3.....1....12222242234131.1...1.1......11
pNG6120         :::K:::DK::::::::::K:::::S:::::::QD----FSHLP:A:::K::::::::DH
Hut2396         V:-:::ED:::::PS::::::::::S:::::M:QD----VSHL:::::::::::::::DH
HQ3584A         ::::::::::::::::DM:V:::::S::::AR:EEGP:YLF:K::::::::E:::::::H
HVO_A0409       ::::::::::T:Q::::::I::::::::::::A::::E::D::::A::::::::::::::
VNG6403         :::P::::::A:E:E:E:::::::::::::::A:::E:::::::::::::::::::::::
HVO_A0374       :::P::::::::E:A:E:::::::::::::::G:::K:::::::::::::::::::::::
HVO_A0019       :::::::::::::::::M:V:::::::::::M:::::E::Y:A:::::::::::::::::
VNG5194         :::P::::::::E:A:E:::::::::::::::A:::E:::::::::::::::::::::::

consensus       ISAQAELGTQDGREQRTREVAAERSAERRREFQ-RAASVDPMADPERDDPRAELTQEQLA
#oth            ..11...22.1..13.1.4112232533123113111113222332.4...32.1131.1
pNG6120         :::::::::::::AK:::K:VT::RQRK:A:--:--------RT:D:T:::ER:SRME::
Hut2396         :::::::TS::::AR:::::VV:DRR:L:::--:----------RR:L:::ER:S::E::
HQ3584A         ::T::::SQ:E::AK:::::VV:QCGR------:-----:EP:PA::T:::KK:::DE::
HVO_A0409       :::R::::S:E:::A:S:VI::::::G:::Q::K:::::N:::::D:A:::T::::A::G
VNG6403         ::::::::::::::::::A::::G:T:::::::Q:::::E::::::::::::::S:DE::
HVO_A0374       ::::::::::::::::::A:::QG:K::::K::Q:::::::::::::G::::::::::::
HVO_A0019       ::::::::::E:::K::::I::K::::::A:::K:::::N::::L::G::::::::::::
VNG5194         ::::::::::::::::::DI::K:::V::A:::T::::::::::::::::::::::::::

consensus       AVNKQAMRLAEKLD-GWSRAAIGRRLAEAVVGGKDLTSAVVGVFEELQTAPGTIVPIGKL
#oth            4..5112.2142222.21..11213.212143.2.312.12413111222.1432..321
pNG6120         K::QE:D:M:QR:RT:H::::VS:A::KR:AK:Q:I:K::FDTMDA:KA:::A:C::EDV
Hut2396         S::RE:D:I:KRF:G:PR::::A:V:::R::R:Q:::E::FETID:WKAE::V:C::ADV
HQ3584A         E::E::::ISDEVQG:::::VVAKQ:::K:QR:Q:V:K::LETL:::KAV::A::::ADV
HVO_A0409       :::S::T:::::::::::::::S:::S:::L::::MM::T:S:::::EG::::M::::::
VNG6403         T::TE:D:::TR::::::::::S::::::I:D:R:::::::R::::::::::GT:::DA:
HVO_A0374       :::::S::::K:::::::::::::::G:::I:::::M::T:::::::::::RQV::::::
HVO_A0019       :::::S::::::::::::::::::::G:::::::::M::::::::::::::::V::::::
VNG5194         :::::S::::::::::::::::::::G::::::::V:::::::::::::::::VI:::::

consensus       EDVNRKEVSIEGTVTQLWEPSSPAIQQVGLIEDESGKTKFTSWKASDQPWIEEGERVRIH
#oth            111434..31..32331.221132.2.1..21.21122.1.1.31.233312..22..22
pNG6120         P::QTD::::::E:V:::DA::RK:A::::VA:DT::I:::::RK:EPAFVQ::DT::MR
Hut2396         P::QSN::D:::KIQT:::::N:::::::::A:GTD:I::::::K::PKIVQ:::T::MY
HQ3584A         P::PVG::TV:::IET::::::SS:::::::A:::::I:::C:EK:G:TVVR::QT::FR
HVO_A0409       :G:S:R::CV:::L:TV::SE::::::A::L:::::QV:L:::::::V:::R::::::::
VNG6403         ::ID:::::V::R::::::::::S:A::::::::::R::L:::::::A::::::::::::
HVO_A0374       ::ID:::::::::::V::::::A::S:::::::D:::::::::::::A::::::::::::
HVO_A0019       ::::::::::::R:::::::::S::S:::::::D:::::::::V::::::::::::::::
VNG5194         :::::::::::::::R::K:::A::S:::::::::::::::::V::E::::::::H::::

consensus       GAAKNWYNGRVSVALTGWSTIHFPERGR-WWEE
#oth            1111...2..1.2.1.121323....121..12
pNG6120         AVK::::E::C:L:V:YD:M:V::::D:R::::
Hut2396         :VK::::D::C:L:V:YH:R:E:::::C::::-
HQ3584A         A::::::E::C:I::::::D:::::::::::::
HVO_A0409       :::R:::D::::::::::T:VM::::DA:::DA
VNG6403         ::::::::::::::V:::::L::::::::::D:
HVO_A0374       ::::::::::::::V:::::L:::::::::::-
HVO_A0019       ::::::::::::::::::::V:::::::::::-
VNG5194         ::::::::::::::::::::V:::::::::::A