[E] (MetC) COG0626 Cystathionine beta-lyases/cystathionine gamma-synthases 4 genomes BUD1917 4 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG0796 rrnAC2414 HVO_2946 Hbo1591 - - - - -

Pairwise sequence scores
Consensus score	2990	HVO_2946	Hbo1591	VNG0796	rrnAC2414
2456	HVO_2946	2988	2323	1869	1775
2453	Hbo1591	2323	2992	1952	1732
2286	VNG0796	1869	1952	3051	1960
2149	rrnAC2414	1775	1732	1960	3053

418 symbols
consensus       ----------MNDSDPRRETLAVTHGERQRAPAAGVEDVVVPIHLASTYAVPEIDPDASL
#oth            11111111112212232111.1121112323213.11..22.1..1..121221.1.11.
HVO_2946        :::::::::::::::V::::::::::::GQ:::P::::::::V::S:::S::S:::::D:
Hbo1591         :::::::::::::::YQF::::::::::::-::E:::::A::V:::::F:::::::::::
VNG0796         ::::::::::-M:DT:AF:::::S:::SP:ETRH:--:::S::::::::::Q:L:T:L::
rrnAC2414       MIAKVLAPASRRERMT::PH:DTIAVDTETTS:::--::TL::::S:::ELAGL:T:L::

consensus       EDLDPDAGEFLYSRLSNPTRNALEHRLAALEGGDHALAFASGTAAIATAALAAVEPGDHI
#oth            .321.11.11.....1....11..211...1.11112..3.....11113312.2....1
HVO_2946        :T:::::::Y::::::::::::::::::::::A::::::V:::::::ATMT:V:R:::::
Hbo1591         :S:::::::Y::::::::::::::::I:::C:::::::::::::::V::IS:::Q:::::
VNG0796         :GV:::D:Q::::::N::::H:::R::::::::::GF::G::::::::::F::::::::V
rrnAC2414       ::IN:GD:::::::::::::HG::QE:::::::ER:Y::S:::::V:::V:SL::::::V

consensus       VAFDDLYAGTRRMLETLFEDRLNVDVSFVDATDPDAVAAAMREETALVWMETPTNPRIKL
#oth            ...1...1..12.122..212.1.2.11...1.212..1.1111.21..1......122.
HVO_2946        :::E:::G::KT::TR::A:::::::::::::::EN::::::::::::::::::::LMH:
Hbo1591         :::::::G::KS::SD::::::::S::L:::R:T:T:::::::::S::::::::::LLR:
VNG0796         :::::::::::::::::::GN:G:A:::::::::::::D:I:P:::F:::::::::::::
rrnAC2414       :::::::::::::F::::R:Q:G:::E::::::A:::::::TPA:E:::V::::::::::

consensus       CDIEAIAAIADDYDATFGVDNTFLSPYFQQPLSLGADVVVHSTTKYLNGHSDAIGGALVT
#oth            ...2...1111121121......21.2..2..2....1.1............11...12.
HVO_2946        :::::::::::EG::V::::::::::Q::T::::::::::::::::::::::S::::V::
Hbo1591         :::::::::::E:G:::::::::VG:H::R::E:::::::::::::::::::S:::::A:
VNG0796         :::A:::D:T::AGVL::::::::::::::::A::::::A:::::::::::::V::::::
rrnAC2414       :::D::::V:A:::::V::::::A:::::::::::::L:::::::::::::::V::::I:

consensus       NDEAVAEEVEFLQRVGLGNMLAPFDAYLTLRGIKTLPLRMRRHEANAMAIAEFLADHEAV
#oth            1222211221.1.1111.1..1...1..21..1...22..23.13..212.11.11.22.
HVO_2946        DR:D:L::LT::::::M:S::S:::S:::::::::::::::Q::T:::E:::::DS::::
Hbo1591         ::::Y:::MT::::::M:::::::::::::::L:::::::EK:AS::Q:V:::::::P::
VNG0796         :ND:L:DS:::::Q::::::::::::::V:::::::AP:::D:::::L::::Y::::DR:
rrnAC2414       D:PE:::R:::R:QIA:::::::::S::IS::::::GV::T:::N::::L:QY:D:::H:

consensus       EAVHYPGLESHPQHDLAARQQSGFGGVLSFELDGDLADAARFLAALEEFPLAVSLGGVES
#oth            12.1....1........32.11.1..1..1..11.111212.13..2212....1.....
HVO_2946        TR:L:::::::::::::::::::::::::::::T::DGT:E::G::R:::::::::::::
Hbo1591         :::::::::::::::::S::M::Y:::::I:::T::DGV:::V::::H::::::::::::
VNG0796         T:::::::D::::::::DA::::Y::I::::::::::::K:::D::D::N::::V:::::
rrnAC2414       :T:::::::::::::::RE:MQ::::::::::A::M:::KQ::E:::TVT::::::::::

consensus       LIEHPAAMTHEPLSQAERDALGISDSLIRLSVGIEHVEDLRADLARALAAL-S-----
#oth            .2.1..3...1.11232.121..1.1.1.1...1.222..21..32113122111111
HVO_2946        ::::::T:::S::::T:::::::::::L:::::V:::D:::S:::S::SV::-:::::
Hbo1591         ::::::S:::S::::E:::M:::T:::L:::::V::EA::LS::SD::DVI:-:::::
VNG0796         :V:L::G:::::IPKPD:E:M::T:::::V:::::AI:::I:::D:GFE:VR:TTPTA
rrnAC2414       :A:L::::::::::P:A::E:::::T:::::::::D::::::::E:GF:::E::::::