[C] (EutG) COG1454 Alcohol dehydrogenase, class IV 4 genomes BUD2004 4 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG2171 rrnAC1300 - Hbo4038 - - hla2336 - -

Pairwise sequence scores
Consensus score	2944	hla2336	VNG2171	rrnAC1300	Hbo4038
1602	hla2336	3023	1104	1215	737
2148	VNG2171	1104	2956	1654	831
2213	rrnAC1300	1215	1654	3058	922
1132	Hbo4038	737	831	922	1599

417 symbols
consensus       M-DLPAA------FRFDYDGAALRYGPDAVRDLGAALDERDADRALVVCGSTVGATPAVM
#oth            123313121111212221333321222231231233112333231111212211322221
hla2336         -:M::I:D::::S:EH::Q:CEI:::RGR:AE::D:::::ELGD:::::::N:::NEDL:
VNG2171         :SQS::::::::::::::ESP:::F:::S::::D:S::AH:::T::::T:::::T:::::
rrnAC1300       :A:T:V:GDLEAP:::E::P:T:::A:::::S::TE:::QGY::::::::T:::E:::::
Hbo4038         -:-----::::::-----------------------------------------------

consensus       DPVRDGLGDRLAGVFAETTPAKRLETAFDALERRAEADADALVAVGGGSSLDVARQAAAL
#oth            112121111111111221123112311213221322321122111111112121332331
hla2336         ::I:E::::::::::DG:::D::V:::::L:D::::VG::::::::::::::I::::TL:
VNG2171         :::::::::::::::::::GE:::T:::::A::V:AT::::I::::::::I:::TV::::
rrnAC1300       ::::::::::::::::::::::::G::Y:G:::FR:::::C:::::::::::::KIISI:
Hbo4038         ------------------------------------------------------------

consensus       AATDRD----RAAVARAAADLGTIAIPDAALPPIVVVPTTLAGADISQGAGIAA-APDAC
#oth            332322111122223333323223232332221222211121111313222332132123
hla2336         DVDG::LADL::DAEVG:DA::DL:PRTDPAL:V::I:::F::::V:T:GSLEVLDA::S
VNG2171         TG:TQS::::::::::TVR:TA:VP:::G::::::::::::::::::::::::::H:::G
rrnAC1300       ::::::::::PT::GT:F::S::::V:E::::::IA:::::::::L:IV::VT:::::T:
Hbo4038         ------::::--------------------------------------------:-----

consensus       PVDDPAS--VSDRRLMPAAACADPVLFATTPRSVLAASAMNGFNKGIETLYAANATPITD
#oth            222323222222332..12331..2.21...211..1.....11.....2..12.1.11.
hla2336         :TGQ:MT::::GGGA:::IDL:::A::E:::Q::::G::::::::::::P:::D:S:VS:
VNG2171         V:::TH:AVAD:::::::SVV:::::A:::::::::G:::::L::::::::::T::::::
rrnAC1300       :::E:::GG:::PE:::::::Y::E:I::::::::::::::::D::::::::::::::::
Hbo4038         -------::------::R:TFY:::::::::KQI:::::::::D:::::I::R:::::::

consensus       ATASHGLGLLAAGLRAL-GNADDDPAALAPVAQGLLLVQYGISRPNATTLSLIHAFGHAL
#oth            ...11.221.331.2221133222132332232.11..11.111233111.21..1..11
hla2336         :::V::TR::RDA:PHVA:DRP:::::TDRAVV:A::::L:------RKI:V::::::GF
VNG2171         ::::::V:T::::::::::T::PT:ETM::ILR:::::E::::::D::::::T:::::::
rrnAC1300       ::::::::::TE::L:F:::G::::WVYQS:T:::M::::::::A:G::::::::L::G:
Hbo4038         :::VR::K::EG:::Q::NEQSVSEK::E::::::::::::::::GE::::I::::::::

consensus       TRASDVQQGAAHAIIAPHVLAYLFDNVDGRRRLLAAALGVG----DDAAPAEAVVDAVAA
#oth            2.3221...22.1111..1.11..131111.32..31.2121111.23221211123.32
hla2336         A:RY:::::TV::VV::::::::::E::AS::A::NG:::ATAGR::::I::D::SE:::
VNG2171         S:::PI:::V:::VVT:::::H:::ST::::DR:::::D::::::::PD::S::I:::T:
rrnAC1300       ::TD::::::::G:::::A:S:::EQ:::::S:::D::::::::::ADN:GT::::R:SE
Hbo4038         ::S:A:::::M:G:::::::S:::E::A:::E:::E::-CS:::::VS:S::DI:AS:EW

consensus       VRDALGLPSRLRDVDGPDRAEFPAVAEAVLADPFMANAPSGLDPTREDIAGVLRAAW
#oth            .112.21.21..1211112221121.22222.211311.21122.2221321.23.1
hla2336         :::S:PV:::::EL:PV:EDD:::I::YIAD:WS:EQ::AD::A:P:A:E::::E::
VNG2171         ::::::::A::::T:::A:S:LQ:::A:AV::::VD:::D:VPL::A:ATEI:D:::
rrnAC1300       :VTT::::TQ::::A::::::::E::D:::E:A::M:V::::E:::D::V:::ES::
Hbo4038         :::::S::::::::::::P:A::D:::S:::::::::::::::::S:E::D:::D:Y