[C] (-) COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases 4 genomes BUD2098 5 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1342 rrnAC0239 - - Hmu1091 - - NP1902A NP4374A -

Pairwise sequence scores
Consensus score	2564	NP4374A	VNG1342	NP1902A	rrnAC0239	Hmu1091
1392	NP4374A	2505	859	1130	1176	1196
1354	VNG1342	859	1902	1085	1114	1205
2065	NP1902A	1130	1085	2596	1787	1863
2053	rrnAC0239	1176	1114	1787	2853	2002
2209	Hmu1091	1196	1205	1863	2002	2557

375 symbols
consensus       --------------------------------------MARDVFLPVAAQPSVDTLVEMA
#oth            111111111111111111111111111111111111113411231112222221321332
NP4374A         :::::::::::::::::::::::::::::::::::::MVD::IV::-SGLD:L:DV:AV:
VNG1342         ::::::::::::::::::::::::::::::::::::::----------------------
NP1902A         :::::::::::::::::::::::::::::::::::::::P::::::::::::::A:::Q:
rrnAC0239       MWLYLPCGRTASHVSDTYVPVANRSLPGHRTTRGGRQMT::::Y:::::::::::::G:S
Hmu1091         :::::::::::::::::::::::::::::::::::::::N:::::::::::G:::::::S

consensus       QRAESLGYDRVWLPETWGRDAVTTLTCIAARTDRIGIGTSIMNVYSRSPALIGQTAATLQ
#oth            132132111232111221112112123214413422223223322211112211222121
NP4374A         ::::::::::LS:::VT:::G::L:ATL::::::::LSNDVFSPWG::::ML:::GV:V:
VNG1342         ------------------------------------------------------------
NP1902A         :LG:Q::::TA::::::::::::::::::QG::D:D::::::P:::::::::::S:::::
rrnAC0239       :Q::DR::::::::::::::::::::S::EH:STV:L:S::L:::::::::L::::::::
Hmu1091         :::::::::::::::::::::::::::::RE:ESV:::::::::::::::::::::::::

consensus       EVSDGRFRAGLGPSGPAVIEGWHGVDFERPLRRTRETIDIVKQVLAGEEVDYDGDIFDLS
#oth            12131131412.1.1.41111..133112..111..11.1212.12.1211...131223
NP4374A         :A:G::Y:M:::T:S:NLT::::LAAY::::::L::::::IR::T::::L:::::H::GG
VNG1342         ----------M::::::::Q::::QS::::::::::Y::V:RA::T:DP::::::LIQTQ
NP1902A         ::::::::L:::::::V:::N::::::GN::::::::V:V::::::::::T:::EY:::E
rrnAC0239       ::::::::::V:::::I:::::::RE::S::KY::::V::M::::S::T::::::::S::
Hmu1091         :::N::L:I:::::::M:::::::::::::::Y:::::::::S:::::T::::::::Q::

consensus       GFRLRCDPPEPAPPVDAAGLGPKAVELAGRFADGWHALLFTADGLRDRLEDFRRGADLGD
#oth            .1...222.212.31.1211...1.......1...11112.321111..1.121.321..
NP4374A         :L:::GVE:RSV:-::V:A::::::::::::::::VPQ:::VAA:E:::::L::::A:::
VNG1342         :::::Q:A:D:::AI:VT:M::::::::::::::::::::::::I:E::A:L:::M::::
NP1902A         :::::::::::T:::::::M:::::::::::::::::::::R::I:::::::D::SEM::
rrnAC0239       ::::::E::::::::::G:::::S::::::::::::::ML::::::::::::EH::::::
Hmu1091         ::::::E::::V:GI::G:::::S:::::::G::::::MT:KE:::::::::E::G::::

consensus       RDRDDQRVTLSLPCCALDDAAEARRLARQHLAFYVGGMGTFYRDSLARQGYEATAHEIAD
#oth            .1222211112121.122.223.14121113..11.11.21..111....2.22131123
NP4374A         :ST::L::AVTVRS:::E::SR::TA::KQ:::M::AY:PY::Q:I::::F::ATDD:HG
VNG1342         ::A:AVQT::VV::::QP:::A::D:T::::::::::::E:::::::::::::P:TDVY:
NP1902A         ::::::::::::T::V::::E::KS:VK::T:::I:::::::::::::::H:E:::::Y:
rrnAC0239       :::A::::::::T:::M::REQ::E:::::V:::I:::::::::A:::::::D::Y:::E
Hmu1091         :::SE::::::::::::::G::::::T:::I:::::::::::::A:::::::D::::::Q

consensus       AWQDGDHEAAMDAIDDDLLDAIAAAGTPEDCRDRFARFADIDGVDAVSVSFPRAADADQI
#oth            3.32.1331.231221111122111..12321123231121...1123111112114231
NP4374A         ::T:::RQR:IE:VTEEMV:SLV::::::AV:ETVR:YEAV::::::RIGYFGDM:::ER
VNG1342         ::::::::R:VGLVT::::::F:::::QA:V:::L:A::G:::::::A::::::::NAV:
NP1902A         H:::::QA:::::L:::::EE::VW:::DTAP:H:E::::::::ESA::::::G::L:::
rrnAC0239       Q:GS:NKG::V:::S:E:::S::V::::::::::I:Q:E:::::::INI::::::ER:T:
Hmu1091         E:AG:::::::A:::::::::L:::::::Q::E:::S:::::::::::::::::::PE::

consensus       DATLAALAPA-----
#oth            24.3411..422111
NP4374A         RQ:TN::::SDG:::
VNG1342         :D::::V:::PAHTP
NP1902A         ES:MR::::E:::::
rrnAC0239       :T:IDV:::-:::::
Hmu1091         ::::S::::D:::::