[L] (-) COG3316 Transposase and inactivated derivatives 4 genomes BUD2140 9 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG6430 pNG5042 rrnAC0369 rrnAC0544 rrnAC3387 - - - - hla1755 hla1772 hla2405 NP4638A -

Pairwise sequence scores
Consensus score	1608	hla1755	hla1772	hla2405	VNG6430	pNG5042	rrnAC0369	rrnAC0544	NP4638A	rrnAC3387
959	hla1755	1656	1656	1205	665	743	743	743	863	840
959	hla1772	1656	1656	1205	665	743	743	743	863	840
787	hla2405	1205	1205	1408	543	606	606	606	674	654
1163	VNG6430	665	665	543	1401	1142	1142	1142	842	874
1381	pNG5042	743	743	606	1142	1619	1619	1619	937	918
1381	rrnAC0369	743	743	606	1142	1619	1619	1619	937	918
1381	rrnAC0544	743	743	606	1142	1619	1619	1619	937	918
1082	NP4638A	863	863	674	842	937	937	937	1610	1167
1101	rrnAC3387	840	840	654	874	918	918	918	1167	1611

212 symbols
consensus       MAENARLSGGIDWIDLDFVERERTPRLAMKLGIQLHLAGLSLSNTVSVLEIFGVQRSRSA
#oth            13233213343221213211122114521211.12.1..1..211235..42.13.1121
hla1755         :::FD:::E::A::::S::::D::::W:IEV::RC::::M::REVSKH::R:::D::HV:
hla1772         :::FD:::E::A::::S::::D::::W:IEV::RC::::M::REVSKH::R:::D::HV:
hla2405         :S:FD::ND::A::::S::::D:::LC:IEV::RC::::M::CEVSKF::EY:ID::HV:
VNG6430         ----------------------------:::S:::::::::::::::I::::::E:A::T
pNG5042         :PK::G:G:S::Q:::::::::A::::L:::S::::::::::::::::::::::::A::T
rrnAC0369       :PK::G:G:S::Q:::::::::A::::L:::S::::::::::::::::::::::::A::T
rrnAC0544       :PK::G:G:S::Q:::::::::A::::L:::S::::::::::::::::::::::::A::T
NP4638A         :::I:::::RS:::E::V:::::::SEL:::::R:::::::::::IRE::K:::N:::K:
rrnAC3387       :::IT::::CR:::::G::::::::EP::A::::S:V:::::::::EL::DL::::::K:

consensus       VHNWVHKADLQPISGQSPDHVAVDETVIRLNGQQFWLYAAVDPQTNELLHTKLRPTTTKV
#oth            111..1...1..4124.2112.1..11.1112111...1.11.31.111.32.32.2.23
hla1755         I:::::::::::::TV:A:QL::::KM:::H:::::::G::::Y:::I::VS:Y:::::Q
hla1772         I:::::::::::::TV:A:QL::::KM:::H:::::::G::::Y:::I::VS:Y:::::Q
hla2405         I::::::::R::::TV:V:QL:::::M:::H:::::::G::::Y:::IF:VS:Y::A::Q
VNG6430         ::::::::::::E::R:::::::::::::::NE:Y::::::N:E:::::::::E::R:N:
pNG5042         :Y::::::::::KD::::::::::::::Q:::ERY:::::::::::K:::::::::::::
rrnAC0369       :Y::::::::::KD::::::::::::::Q:::ERY:::::::::::K:::::::::::::
rrnAC0544       :Y::::::::::KD::::::::::::::Q:::ERY:::::::::::K:::::::::::::
NP4638A         ::D::Q::::::ADDA::::I:L::::::I:::::::::::::D::::::LR:FT:::TA
rrnAC3387       ::D::Q::::::D::K::NQI:L::::::I:D::::::::A:::S:::::IR:FA:::TT

consensus       LARAFLTELHQKHDVDDAVFLVDGARSLQAVLQRHGLRFRYERHGNRNAVERVFREIKRR
#oth            2134.122.3211212112....2333.3311212.31.1432.....11..1.111111
hla1755         TT:W:::D:::RYRLN:VE::::D:DY:GP::AED:Y:::VI:::::::I::::W::E::
hla1772         TT:W:::D:::RYRLN:VE::::D:DY:GP::AED:Y:::VI:::::::I::::W::E::
hla2405         T::W::::::RRYQL::VK::::DVDY:GP::AED:C::QIIQ::::::I::::W::E--
VNG6430         I::S:FAK:RE:::::T::::::::PT:KDAC:::::::Q::K:::::T:::::::::::
pNG5042         ::H::::::SE:::::::::::::S::::::C::::FD::::K:::::::::::::::::
rrnAC0369       ::H::::::SE:::::::::::::S::::::C::::FD::::K:::::::::::::::::
rrnAC0544       ::H::::::SE:::::::::::::S::::::C::::FD::::K:::::::::::::::::
NP4638A         :TQT::R::Q:::::E:::::::YTQH:ATA:R:A::::QTV:::::::::::::D::::
rrnAC3387       :TEI::R::R:::::ET::::::::QH::TA:::A::::QMS::::::::::I:::L:::

consensus       TSSFSNCFSNAEAETADDWLRSFAFAWNQLI-
#oth            13212121122333113312421233213331
hla1755         ::::A:S:::VAL:::QN::EA::VYH:SRQT
hla1772         ::::A:S:::VAL:::QN::EA::VYH:SRQT
hla2405         -------------------------------:
VNG6430         :::::::::::A:D:::::::::S::::::::
pNG5042         :VC::::::::::::::::I:::S::::::::
rrnAC0369       :VC::::::::::::::::I:::S::::::::
rrnAC0544       :VC::::::::::::::::I:::S::::::::
NP4638A         :P::::S::HVQPT::EI::QA::VW::S:N:
rrnAC3387       :::::::::HV:P:::EN::L:::RWH:ATN: