4 genomes BUD2141 7 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi VNG1064 VNG6341 pNG1041 pNG5063 - - - - hla0524 hla1020 NP6002A -

Pairwise sequence scores
Consensus score	3388	hla0524	hla1020	NP6002A	pNG1041	VNG1064	VNG6341	pNG5063
3086	hla0524	3370	3362	2916	361	3041	3045	2959
3078	hla1020	3362	3373	2908	361	3033	3037	2951
3136	NP6002A	2916	2908	3411	374	3116	3120	3033
390	pNG1041	361	361	374	406	388	388	377
3343	VNG1064	3041	3033	3116	388	3402	3397	3237
3347	VNG6341	3045	3037	3120	388	3397	3401	3236
3246	pNG5063	2959	2951	3033	377	3237	3236	3391

446 symbols
consensus       MHATIDVRLTVSIDDDKTIPLATLAEFITDQNVESVLLEGLVESLDAARVEALCGEKHAH
#oth            111111112221111211211111113211113121111211111112211111111122
hla0524         ::::::::FEL:::::::L:::::::AV::::L:A::::S::::::::S:::::::::::
hla1020         ::::::::FEL:::::::L:::::::AV::::L:A::::S::::::::S:::::::::::
NP6002A         :::::::::::::::H::::::::::S:::::I:::::::::::::::::::::::::T:
pNG1041         ------------------------------------------------------------
VNG1064         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG6341         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
pNG5063         :::::::::::::::::::::::::::::::::::::::::::::::S:::::::::::N

consensus       GNGDQRFQRAGTDTRTAVTTAGEHEFDLHYVEDTAADHDESSYFRPVEDVLSFDGQNRYQ
#oth            111321111111111111121111122111121121221121111111111311111111
hla0524         ::::::::::::::::::::::::::S:::::::::SP:::::::::::::D::::::::
hla1020         ::::::::::::::::::::::::::S:::::::::SP:::::::::::::D::::::::
NP6002A         :::EN::::::::::::::::::::L:::::K:::::::::::::::::::G::::::::
pNG1041         ------------------------------------------------------------
VNG1064         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG6341         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
pNG5063         :::Q:::::::::::::::A::::::S:::::::D:::::T:::::::::::::::::::

consensus       QDIAAKSVDLATSLSYRDAADHGDGILS-MPSPTTINRRAREYGSKLKQFLPDCVADTDA
#oth            111111111111111111212111223231111111112222113111111111112121
hla0524         ::::::::::::::::::::N:::SFV:::::::::::::KK::H:::::::::::G:::
hla1020         ::::::::::::::::::::N:::SFV:::::::::::H:KK::H:::::::::::G:::
NP6002A         ::::::::::::::::::::::::::FER::::::::::TK:::T:::::::::::::::
pNG1041         ----------------------------:-------------------------------
VNG1064         ::::::::::::::::::::::::::::K:::::::::::::::::::::::::::::::
VNG6341         ::::::::::::::::::::::::::::K:::::::::::::::::::::::::::::::
pNG5063         ::::::::::::::::::T:::::::::E:::::::::::::::::::::::::::::E:

consensus       DAVIPDGTKCHSQDDDRSYHSVQATLGEDTAEESRSLLDLSVNADWDETAADLDDIGAVT
#oth            111211112111112112211111111121111111111112112113111212112111
hla0524         ::::::::::::::::::S::::::::::::::::::::::::::::::::E::::::::
hla1020         ::::::::::::::::::S::::::::::::::::::::::::::::::::E::::::::
NP6002A         ::::::::Q:::::E:::::::::::::N::::::::::::::::::::::E:E::::::
pNG1041         ------------------------------------------------------------
VNG1064         :::::::::::::::::T:::::::::::::::::::::::::::::Q::::::::D:::
VNG6341         :::::::::::::::::T::::::::::::::::::::::::::::::::::::::D:::
pNG5063         :::T:::::::::::::::::::::::::::::::::::::A::E::K::::::::::::

consensus       DDATVVSDADDGIVTAFTDENSDHQLDLVHVGRTLDYNLWDDGVFSLDRRNEIVSEVIDE
#oth            111111112121112111113211111111111112121111111111212211111122
hla0524         ::::::::::S::::::::::R:::::::::::::G:T::::::::::::K:::::::::
hla1020         ::::::::::S::::::::::R:::::::::::::G:T::::::::::::K:::::::::
NP6002A         ::::::::G:S:::::::::H::::::::::::::::::::::::::::::Q::::::ED
pNG1041         ------------------------------------------------------------
VNG1064         ::::::::::::::::::::Y:::::::::::::::::::::::::::::::::::::::
VNG6341         ::::::::::::::::::::Y:::::::::::::::::::::::::::::::::::::::
pNG5063         ::::::::::::::A:::::H:::::::::::::::::::::::::::Q:::::::::::

consensus       VFHLKNSVAKHRPAEEFAAIRERIARTTERIEKTAWQLDQYGSEKAAGYLRRWLPSIVTF
#oth            121111112111141111111211211211211111113121121112111111111121
hla0524         :::::::::::::::::::::S:::::R::L:::::::E:F::A::::::::::::::::
hla1020         :::::::::::::::::::::S:::::R::L:::::::E:F::A::::::::::::::::
NP6002A         ::::::::I::::E::::::::::T:::::::::::::N::::::::R::::::::::R:
pNG1041         ------------------------------------------------------------
VNG1064         :::::::::::::N::::::::::::::::::::::::::::::::::::::::::::::
VNG6341         :::::::::::::N::::::::::::::::::::::::::::::::::::::::::::::
pNG5063         :L:::::::::::D::::::::::::::::::::::::::::::::::::::::::::::

consensus       AEQAVEGFEVPWTSNPVERLMGEVSKRCKNQWMRWTTEGLEAILQLRLVKYADPEYYQSF
#oth            12213111111111111111111111111111....2.1...............11..2.
hla0524         ::H:::::::::::::::::::::::::::::::::A:::::::::::::::::::::A:
hla1020         ::H:::::::::::::::::::::::::::::::::A:::::::::::::::::::::A:
NP6002A         :K::I:::::::::::::::::::::::::::::::K:::::::::::::::::S:::W:
pNG1041         --------------------------------::::K::::::::::::::::::H::::
VNG1064         ::::A:::::::::::::::::::::::::::::::::::::::::::::::::::::::
VNG6341         ::::A:::::::::::::::::::::::::::::::::::::::::::::::::::::::
pNG5063         ::::::::::::::::::::::::::::::::::::::R:::::::::::::::::::::

consensus       LDELLQRSTKTAMSCDLSIESTRGKL
#oth            .......1....11....1...1..1
hla0524         ::::::::::::IN::::::::S::V
hla1020         ::::::::::::IN::::::::S::V
NP6002A         :::::::P::::::::::::::::::
pNG1041         ::::::::::::::::::::::::::
VNG1064         ::::::::::::::::::V:::::::
VNG6341         ::::::::::::::::::V:::::::
pNG5063         ::::::::::::::::::V:::::::