4 genomes BUD2145 6 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi - pNG5007 pNG5076 rrnAC1577 HVO_C0068 - - - hla2142 NP6250A -

Pairwise sequence scores
Consensus score	2121	pNG5076	pNG5007	NP6250A	rrnAC1577	HVO_C0068	hla2142
1074	pNG5076	1654	928	914	1029	1020	1026
1819	pNG5007	928	2134	1958	1666	1699	1734
1884	NP6250A	914	1958	2130	1752	1770	1759
1920	rrnAC1577	1029	1666	1752	2115	1819	1832
1969	HVO_C0068	1020	1699	1770	1819	2140	1952
1981	hla2142	1026	1734	1759	1832	1952	2131

276 symbols
consensus       --MEVDLLDFVEQCRRLVKQALGKHAGEPASGGFARWKHVVLHCFRLEEGHSYRETPNRL
#oth            111122211111111312111111111111122111121111112121231111111111
pNG5076         ::----------------------------------------------------------
pNG5007         :::::N:::::::::Q:::::::::::::::D::::::::::::::V:D:::::::::::
NP6250A         :::::::::::::::H:::::::::::::::::::::::::::::::::D::::::::::
rrnAC1577       ::::I:I:::::::::::::::::::::::::A::::V::::::::V::E::::::::::
HVO_C0068       LP::I::::::::::H:A:::::::::::::::::::V::::::::::::::::::::::
hla2142         ::::::::::::::::::::::::::::::::::::::::::::L:::D:::::::::::

consensus       EYMAEIRDALGLDRDDLPDYSTIYKSFDRLKMWVWRALLRVSAQQHPQSGHAALDSTFFD
#oth            31121211311.13.2...21.2.1.1..12.11...........1...1.1......11
pNG5076         --:P::C:R:::HS:T:::PT:F:H:L::YA:YI:::::::::::L:::::V::::::IE
pNG5007         Q::TD:C::::::P:::::FT:V:::::::E:::::::::::::::::::::::::::::
NP6250A         ::::::::V:D:::::::::::::::::::::::::::::::::::::::::::::::::
rrnAC1577       :::::L:EIFD::Q:E::::T::::::::::::::::::::::::::::::V::::::::
HVO_C0068       K:I::V:::::::::E::::::::::::::::::::::::::::::::::::::::::::
hla2142         K::::::::::::P:::::::::::::::::::::::::::::::::::E::::::::::

consensus       RRRASSYYRQRSGSNVQTLKVTTLTDVESLAVLDVHISARWKHDTKTGPQVVRRNADDLL
#oth            .131.1111..2.2311.1.1.....2.........131112....1.11.11..1...2
pNG5076         :QQ::QH:L::C:RR:K:I:A:::::T:::::::::CCIERE::::A::R::H::V:::R
pNG5007         ::S:::::::::::::::::::::::R:::::::::::::::::::::T:::::::::::
NP6250A         ::S:::::::::::::::::::::::R:::::::::::::::::::::::::::::::::
rrnAC1577       ::IS:::::::::NS::::::::::::::::::::::::::Q:::::::::G::::::::
HVO_C0068       :::::::F::::::T::::::::::::::::::::::T:::::::::::::::::::::Q
hla2142         :::::::F:::A:RTI:::::::::::::::::::::A:::::::::::::::::::::Q

consensus       SVAADNGFQDWNTEYEIAALDVEYLVHYRGSSPNAAANNALIRAKGYSQRWMAETSYSTT
#oth            ..1..11.12.211.121.22111.111...1331323.1.1.211.2.......11.13
pNG5076         ::V:::::::::R::QV:::N:::::::::::MM:T:::::::::::T:::::::TC:SV
pNG5007         :::::KA:HS:I:K::FY::G::P:ILQ:::R:LTLGH:::::T::::::::::::::::
NP6250A         :::::KA:HN:I:K::FY::G::P:ILQ:::R:LTVGY:::::T:::A::::::::::::
rrnAC1577       :::::::::::::::::::::ID:::::::::L::T:::T:::S:V:::::::::::::I
HVO_C0068       :::::::::::H:::::::Y:::::::::::::K::L::::N::N::::::::::::::A
hla2142         :::::::::::H:::::::H:ID:::::::::A::::K:::N::::::::::::::::::

consensus       KRSLGDAVRALGWYRQFREIVLMFAISNIEPLCEPL
#oth            ..111111.111..........1..23..12.111.
pNG5076         ::TQAA:L:SRF::::::::::L::LN::KK:ART:
pNG5007         ::::::T:::::::::::::::::::::::::::::
NP6250A         :::::::::::::::::::::::::T::::::::::
rrnAC1577       ::::::::::::::::::::::::::::::::::::
HVO_C0068       ::::::::::::::::::::::::::I:::S:::::
hla2142         ::::::::::::::::::::::::::T:::::::::