4 genomes BUD2147 4 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi - pNG7324 HVO_B0260 - - - hla2273 NP3588A -

Pairwise sequence scores
Consensus score	3998	pNG7324	NP3588A	HVO_B0260	hla2273
2314	pNG7324	4849	1503	1727	1635
2478	NP3588A	1503	3941	1886	1744
3088	HVO_B0260	1727	1886	4084	2508
2875	hla2273	1635	1744	2508	4238

685 symbols
consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
pNG7324         MLASDGVDRLASRCGIVIYVFDTEYRRMATSDASGISEIVGRLLVPLCAASGALVLAGFF
NP3588A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HVO_B0260       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla2273         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       -------------------------------------ASAPSSSN-----------RAIR
#oth            111111111111111111111111111111111111232212123111111111113223
pNG7324         FPTLVGEAVTGPAWLTIALVFFSSGLCYIALLPYSED:T::AAADVLLRVRRTKVR:::K
NP3588A         ::::::::::::::::::::::::::::::::::::MSQR:::VS:::::::::::ESL:
HVO_B0260       :::::::::::::::::::::::::::::::::::::V::V:::::::::::::::G:VS
hla2273         :::::::::::::::::::::::::::::::::::::M:D:G::-:::::::::::-M:D

consensus       EFLNEIDPVIFAFGALITVGFVGAFAANPAAVQAGI----DWALATF----NWLFLAAML
#oth            1.23121.2211111222221222233312223321222222221122222212212211
pNG7324         :::TQHE:A:L::PV:VFAA:F:LQI:F::RTTGAV:::::A:A::VLRDGGP:::::VF
NP3588A         S:I::L:::P:LV::V:S::::IYT:YDV::::::::::::::FG:LGERLA::Y::G::
HVO_B0260       :::D::E::::::::A::LL:::::SL::EGSYEFVLGIRR:I::::::::::F::I:::
hla2273         ::RE::::IV::::::L:::VIA::FIS:S::EN::SSLNNQL:GA:::::::AMMLIVF

consensus       LIVLFLLFLIVGPWGNIKLG--DEPPEYSFLSYFAMLFSAGLAAGIVFWGPAEALFHYNT
#oth            23122221122111.3211.11122.1.21121111311..21..2..1..1...11.32
pNG7324         :S:CYC:::LL::::E::::GP:TE:S:TYPT::TLV:T::I:::L:::::T::::::DQ
NP3588A         ALIVLAAY:M:SSY:SVT::::TG:::::YPA:V::F:::::S:::::F::::::G::Q:
HVO_B0260       GF::::G:V:F:::::L:::::::D:::G:::::::MY::::::::::::::::::::S:
hla2273         :::::::::::::::G::F:::::::::::::F::::Y:::F:::V:::::T::::Y::N

consensus       PPPLF-GA-EAGSAGAMNGAVQYTIFHWGLSAWSAFTVIGLAIAYFAYNYD-APLRVSTA
#oth            11.121122222132.233.12111..121211231221.2111..1121111.1...21
pNG7324         :::YI::::A:::P::V:::LV::L::::V:::::YA:::VP:::::FTRG::::::::V
NP3588A         :::::E:SVGPA:E::IVP::A:::::Y:::::GGYLA:::PV:::::K:::::F:::::
HVO_B0260       V:::Y::::::Q:SA::PL::::S::::S:TQ::C:::M::::G::V:::::::::::AV
hla2273         :S::::SNI:G:T:E::TI:::Q:L:::A:PQLAV::IM:I::G:::::::NV:::::S:

consensus       LTPILGADNLDGAAAKAVDILAVFATIGGIATSLGFIGSQFLTGINFQWGIQAGDVGTIL
#oth            .2.2..2121.123123..1...1..1..1..1111122.121.121111223112122.
pNG7324         :A:L::V:E::S:W:TL::T:::::::::::::VALVSE:::A:::Y::DVA::E::PV:
NP3588A         :Y:V::TER:::VV:R:::T:::V::::::::G::::AT:L::::T:ET:R:FS:AE:::
HVO_B0260       :::::::::V:::IG:T:::::::::L::V:::::::::::I::L:::::::L:::::::
hla2273         ::::::::::::P:::V::::::::::::V:::::::::::V::LDY::::NM::L:IL:

consensus       VITGMTLIFTISLVLGVDRGIRRLSNFNIVLFGLLMLATLIVGPTLFILNLGTQALGGYV
#oth            21112112.13.222.121....2121.12111112122222..1121132.11.2.221
pNG7324         FVG:L::::VV:SAT:IH:::::IAGL:::::::FA:LIAA:::R::::QR::::::T::
NP3588A         A:::I:VF::L::IA::S:::::V:Q:::G:MV::L:VA:VA::::AL::T:VA:::S:G
HVO_B0260       :::::VV:::::::::::K:::::::::M:V::::::::::F:::FR::E:::::T::F:
hla2273         :V:M:::L::T:M:::::K:::::::::MI::VV::F::F:::::::LVL:::::F::M:

consensus       ADFFQMSLFTGAD--GAAD-----WVAAWTVFYWSWWLAWAPFAGLFIARISRGRTVREV
#oth            22.121..1111322223311111.21....11.2.221.1..1...1.11.1..21.1.
pNG7324         VE:VPL::H::GQ::----::::::::::::WN::::FS::::::::::AL::::R::T:
NP3588A         :N:::::::L::::::G:E::::::A:::::::::::I:::::V:::L::::::::I:T:
HVO_B0260       G:::::::::Q:TATS:SK:::::::N:::::::L:P:::S::::::::::::::S::::
hla2273         :::VS:::::::GPM::G:GSATG:IN:::::::A:A:S:S:::::::::::K:::::::

consensus       AFTGIVATSAATAPWFTIVGGTSVWAQHTGAADILAPIA-EAG-EAVAGFVLFGSL----
#oth            11122111131132..231..22123112.311311212223.12211.12..2211111
pNG7324         V::SV:::::::MV::LLL::::LFI:Q::Q:::::A::QRG:S::::::P::A::::::
NP3588A         VG:AF:TMTVTS:I:::V:::S:::LH:L:VV:L:G:VG::F::NGI::::::::F::::
HVO_B0260       ::A::G:::L::V:::A::::AG:IM::::::NV:G:VS::Y:::::S:Y::::N:::::
hla2273         :::::::::G::I::::F::::A:::::N:I::FS:V::GN:::PE:S::I::EA:NFTL

consensus       ---------PI-GALLQFAFLVLVTTFFVTSADSSTLAVSMLTTGGKAAPSAANRIFWGV
#oth            111111111121.311321.22.111.11....1...111111.11232..23112..11
pNG7324         ::::::::::L::Q::M:L::A:IIV:MA::::T:::V::V:A:RRGM::::THIV:::I
NP3588A         :::::::::TG:::VW:LL:F:::::::::::::::::LG::::::ER:::K:::A::::
HVO_B0260       :::::::::::A:P::L::::::::::::::::::::::::M:::::EE:::L:::::A:
hla2273         NLGGASMTI::::SV:IY::MI:::::::::::::::::::M::::::K::NI:::::::

consensus       LQGAVASILMVLGG---ANALQSAAIITGAPFAVICLVALLGLIRTFQRDY---L-QNET
#oth            21.32.221221..111121.122112..2...21122.321123223322222121321
pNG7324         F::S::VSVLL:::::::ET::AL:VL::G:::::S:::VG::TV:WY::E:::-::GH:
NP3588A         :::VI::V:V:V::::::T::R:SV:V:::::::V:::::A:FV-------:::-:----
HVO_B0260       :::::::::::V:::::V:::::::::::::::I::VI:T::::::::Q::GSL:L:D::
hla2273         VL:LT:A:::I:::SGS::T::Q::::::T:::FV:FL:M:S::KD:GEN:DQV:F::::

consensus       RLWGRADRADPDAQAVNDASHDDD-
#oth            3112323333233232332232111
pNG7324         S:FR::V:KL::I:THH:VDPPEKK
NP3588A         -Y:LW::TPE:ST:GASG::VS:::
HVO_B0260       ::::KSESTGGQ:P:::VS::::::
hla2273         V:::SGKD::SPSSS:ES:GS::::