4 genomes BUD2199 4 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi - pNG7365 HVO_2225 Hbo1931 - - - - HQ1758A

Pairwise sequence scores
Consensus score	2471	HVO_2225	Hbo1931	pNG7365	HQ1758A
1709	HVO_2225	2601	1725	1007	863
1788	Hbo1931	1725	2478	1029	926
1562	pNG7365	1007	1029	2774	1272
1445	HQ1758A	863	926	1272	2882

431 symbols
consensus       -----------------------------C-------P--F--------M-----MHTAT
#oth            11111111111111111111122222222111111111221222222221222222.112
HVO_2225        :::::::::::::::::::::::::::::-:::::::-::-::::::::-:::::::::E
Hbo1931         :::::::::::::::::::::::::::::-:::::::-::-::::::::-:::::::::K
pNG7365         MTSTRCVHTIDGPVSGSASVSKEYHSTAP:GTAVLLL:AF:ICATLDID:DYTAVT::T:
HQ1758A         :::::::::::::::::::::MSLLQSDC:::::::::EV:VATGIEVG:GVEPTQ:KT:

consensus       TRTLGRLPSGRDVSTTVHRYR---GGDGPTVYVQAAQHGREINGPAALRRLHNRLDDAAL
#oth            122.211.1121121...1.3111112...1.1......1.1..1111..1.31.32231
HVO_2225        :V::T:::::VP:Q::::T:EPAD:T::::L:::::::::::::TEV:::::GH:ER:E:
Hbo1931         :L::A:::::MP:E::::T:G:::D:T:::::::::::::::::TEVI::I:E:::SDD:
pNG7365         D:R:::::::::::V:::::V:::::P:::::I::::::I:L::::::::::D::T:::I
HQ1758A         ::Q::QT:A-::I:V::::::::::::::::::::::::I:L:::::::::::::C:TK:

consensus       AGTVVVVPVANPLAFDRRSYATPEELDAVNPNMNRVWPGDEDGSLQQRMAAALWELAADA
#oth            1.1122...211.1..21..3..221.2221.2......122..112121.3..11232.
HVO_2225        S:R::A::::D::T:::V::V:::V::S::S:::::::::P::::H:::::T:::YIS::
Hbo1931         S::L:T::::D::T:::V::T:::S::::HS::::::::::E:::HE::::::::Y:GE:
pNG7365         ::::L::::V:Q::::H:::M::G:Y:VM:::L::::::::C::::KQF::R::::VQ::
HQ1758A         ::::I::::M::::::A::::::D:Y::QY::V::::::AD:::F::QIV:E::S:::S:

consensus       DAAVDLHTGSPDMLEHTRYLAGDDAARRLAEAFGTNYRLA-------------EAAGDRA
#oth            .111.....112..1.112231.33222..2...1321.211111111111112221122
HVO_2225        ::I:::::::::::T::V::R::EES:D::R:::VDIL::::::::::::::::::::E:
Hbo1931         :YI::::::::E::T::V::D:::DC:::::::::ELL::::::::::::::::::::D:
pNG7365         :::::::::TA:::::V:CR:::P::E::::::::S:::T:::::::::::::----::P
HQ1758A         :::I:::::T:S::::V:VVED:HK:TA::T::::::::IGDGPVSSQSPSEVSYT:N:D

consensus       DDEWADRSF--------------AGKLRVAATRAGIPSITPELANNRQLVEPAIEAGVRG
#oth            112231112111111111111113111.2.212.1..2..2..2111222221222.13.
HVO_2225        ::::TE:::::::::::::::::D::::::::N:::::::::::H:K:::::::V:::E:
Hbo1931         :T::SE:N:::::::::::::::G::::::::::::::::::::H:K::::::::T::::
pNG7365         E:NGG:G:-::::::::::::::S:TF:A:TAE::::V::A::S:S:RIAQD:VA:::D:
HQ1758A         ETSN::G:VRKTQDGEDNRYTQP:ETF:I:M:::Q::T::V::G:S:TVDRSVA:R:AI:

consensus       VCNVLRARGMLSGA-------PEPPAAQTTLRNDLGRVQAAASGLFEPRPDAELGRQVRA
#oth            13111.3222.22311111111.1213122211122213121....22221321123.33
HVO_2225        :L::C:DM:I:::::::::::V::W-DGR:Y::H::::::::::::VA:E:V::A:E::P
Hbo1931         :F::::EVE::::D:::::::::I::E:::A::H::::S::E::::H:G:::::::::EE
pNG7365         IQ:L::::AV:PSE::::::::::Q::::V::::AEP:T:SE:::::C:::IAV:DT:D:
HQ1758A         ::R:::Q::::TESGMLTDQL::::-T:HQ:KD:IPVSITP:::::::AANCTV:SK:TD

consensus       GDHLGRVYDPTTFEVLQEVTADRAGVIYSLAREATVTAGERLAGIAIPADD-E-D-----
#oth            .12..3..2.111.222222.322.111.221121.21.111111.3.321212121111
HVO_2225        :::::W::::::Y::::::E:E:::LV::I::::::::::T:V:::L:L::G:G:GEEDD
Hbo1931         ::::::::H:::Y:::::A::::::::::VC::::::::QT:V:V:M::::E:P:H::::
pNG7365         :ER::T::E:AS::KQEV:::TER:::F:::::SV:VK::::::::::R--:-:-:::::
HQ1758A         :ET::V::::::::EHATIV:PGS::::::SHGG::F::::V:S::T:IG::-:-:::::

consensus       -----------
#oth            11111111111
HVO_2225        PFDEADGDLDI
Hbo1931         :::::::::::
pNG7365         :::::::::::
HQ1758A         :::::::::::