4 genomes BUD2216 4 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi - - HVO_B0189 Hbo2918 Hmu3287 - - - HQ2245A

Pairwise sequence scores
Consensus score	2140	HQ2245A	Hmu3287	Hbo2918	HVO_B0189
1508	HQ2245A	2512	1180	1168	1245
1512	Hmu3287	1180	2013	1209	1243
1624	Hbo2918	1168	1209	2178	1377
1649	HVO_B0189	1245	1243	1377	2067

339 symbols
consensus       -------------------------NRGRRLSAILGRAAVTLVIFLTLAFLIAPIVVTFV
#oth            11111111111111111111222223333232233123312123221121.13.122.1.
HQ2245A         MSTPDSDSNSNNTQAITGTVPEREPGQLG:::::Y::KLI:VL::V:VG:::G:VLI:::
Hmu3287         :::::::::::::::::::::::::MTTL:TPQS::K::::::TG:V::V:VV::A::::
Hbo2918         ::::::::::::::::::::MSSRM::::SV::LV::PI:R::FA:::L:::F:::::::
HVO_B0189       :::::::::::::::::::::::::--------------:A:TL:A:V::::::::L:V:

consensus       ASFAQSWTGVLPSGFVTAENWRQALGL-ADSIGAQRGAGG-------S-LF-LRLGG---
#oth            1..1221..11.1.11.321.221..111231.211231311111112211213122222
HQ2245A         :::F:N:::I::::GF:VQ::A::::VG:E:::::::L::FWTFVAPDI::I:Q:P:IAD
Hmu3287         S:::::A:::V:T::::::H::T:::::T:V-::R::I:S:::::::G:--:-----:::
Hbo2918         ::::RE:::::::::::LAH:E:V:::::---:Y:DA:NY:::::::::--:::::DVLK
HVO_B0189       ::::A::::::::::::F::::AV::::::T::S::SM:W::::::::P::R:P::::::

consensus       ----DPIDALIPAP----LAFSVLLALGGVVINLVVGVPIAYAVARYEFRGREWLNALAV
#oth            222232333232321111.31.11..11.121..1........11..2.1..112.121.
HQ2245A         ITVSF:F:IR::T:IPVA:G:::::::L::::::L:::::::::T::D:P::RLM:TF::
Hmu3287         ::::----------:::::W::::::T::M:V:::::::::::LT:::::::::::T:::
Hbo2918         TAQH:::G::SAS::::::FR:::::::::A::::::::::::::::R::::::::::::
HVO_B0189       ::::ETLTV:V::E::::::::IG::::::L::::::::::::::::::P::::V::VS:

consensus       LPLVPGIILGIAFLRAYPDLSGTAFGLIVGYSLLKAPFMVLAVQSSFESMDLRQLEESAR
#oth            ..11..1...1...11..21221311.12..1...2.1..11...2.11.1..11.....
HQ2245A         ::I:::::::::::KT::G:PSV-IA:VL::::::I:Y:::::::::::::::SM:::::
Hmu3287         :::::::::::::::T:::NA::::::V:::A:::S:Y:::T:::A:Q::::::::::::
Hbo2918         :::A::::::V:::::::E::::D::::I:::::::::::::::::::A:P:::::::::
HVO_B0189       ::::::V:::V::::::::::A:S::::::::::::::::M::::E::::P:::::::::

consensus       SLGASWPRTFLTVIVPNARRGIVSGAIICWALAAAEFNFSYVVYSRGPRPLALFLQENIS
#oth            ......22..12..1.1.13..21.1..1.1........1.2.222.21.11...321..
HQ2245A         ::::::TT:::R::I:G:KQ::I::S::::T::::::::::::::S::::FS:::F::::
Hmu3287         ::::::::::V::::::::G::LA:S::T:T::::::::T:M::T:::::FS:::Y::::
Hbo2918         ::::::LE:::F::::::K::::::::::::::::::::::::F:::A:::::::KA:::
HVO_B0189       :::::::::::::::::::S:::::::::::::::::::::I:WAN:TQ:::::::RH::

consensus       NSPFLRAAAAISMFFCIVAAVTLLLQRVGRRGFTTRG--
#oth            121.1321..1.21.311111112.13..22..222221
HQ2245A         :N::::::::::IY:V::::::A::NY::EN::SVG:VR
Hmu3287         RA:::QS::::::Y::L:V:AI:V::T:::H::::T-::
Hbo2918         ::S::TTS::V:V::LL::G:::A::L::T::::::Q::
HVO_B0189       ::S:TK::::V::::F:IV::::::::::::::DI::S: