4 genomes BUD2253 4 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi - - HVO_1601 Hbo3003 - - hla1116 - HQ2632A

Pairwise sequence scores
Consensus score	1983	Hbo3003	hla1116	HVO_1601	HQ2632A
1395	Hbo3003	2073	1125	1240	1181
1553	hla1116	1125	3855	1291	1280
1677	HVO_1601	1240	1291	2012	1373
1512	HQ2632A	1181	1280	1373	1799

506 symbols
consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
Hbo3003         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla1116         VAPDIAHAGGVRVAVAGGGRGRVRRGVRLRDDDDRAVVEHPPLDTRNRRRHRARRRRRGR
HVO_1601        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HQ2632A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
Hbo3003         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla1116         LLVERPPRRRDRPARPDAPTGAAARADRVRYRVVRYQPRRRGLYHRRRRVLDQLLRVVRR
HVO_1601        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HQ2632A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       ------------------------------------------------------------
#oth            111111111111111111111111111111111111111111111111111111111111
Hbo3003         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
hla1116         RRRGLRGLTRRGPDARRARRPRHGPIDRPPGVDAGDHDRDPHRARTLLDARRRLRDIRRA
HVO_1601        ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
HQ2632A         ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::

consensus       -------------------------------------------VRVADANADAGAAEDTS
#oth            111111111111111111111111111111111111111111213223313332233222
Hbo3003         ::::::::::::::::::::::::::::::::::::::::::V::::SL:GSD:RN:TG:
hla1116         RRRPRDPAREQQPPRRQGDRVHPRVEPDVPPRRRGVPRGPTEG:S::GV:DGSM:ET::D
HVO_1601        :::::::::::::::::::::::::::::::::::::::::::-MSD:::::::::G:::
HQ2632A         :::::::::::::::::::::::::::::::::::::::::::-----------------

consensus       GTAA---E---VAVDRVGKTYE--SDRQTVRALDDVSFAVEDGEFVCLVGPSGCGKTTLF
#oth            222322212222312322.2121122121.2..21.111.21.....1............
Hbo3003         ::PV:::-:::IE:SG:S:R:D::-N::::D::R:::LT:::::::::::::::::::::
hla1116         :D:ERAV:ESG:::::I:::::GNG:GNP:::::::::::DE::::::::::::::::::
HVO_1601        A:::DSD:AAT:S::SL::::A:::::R::E::S::E::::::::::I::::::::::::
HQ2632A         ----:::-:::----M:T:VF::::E::::::::E:::T:S:::::::::::::::::::

consensus       RIIAGLEDATSGEVRLAGSPVTGPGTDRGMVFQEYGLFPWRTVEENVAFGLEEQGADEPA
#oth            .11...131.2.2.212.21....11.1.1.....2....1..21..2....22233113
Hbo3003         ::V::::PP:::D:FVT::::::::I:::::::::N::::::::G::R::::QPAC:C:D
hla1116         ::::::AE::D:::::::T:::::T::M:V:::::H::::L::::::G::::RSDRS:AE
HVO_1601        ::::::::::::A:T:D::::::::::::::::::::::::::S:::::::::::VE:::
HQ2632A         :V:::::MP:N:::::::NT:::::::::::::::::::::::Q::::::::::::V::N

consensus       RSERVDEMLDLVGLTEFADAYPKELSGGMKQRVAIARALAVDPEILLMDEPFGAVDAQTR
#oth            222..2.111....11.3111..1.........11..1......11.2.....11.....
Hbo3003         CTA::E:LI::::::G:E::::::::::::::::V::::::::::::L:::::SI:::::
hla1116         QA:::::::::::::::R:SH::S:::::::::::::S::::::L:::::::::::::::
HVO_1601        :::::T:::E::::DG:::::::::::::::::G::::::::::LF::::::::::::::
HQ2632A         ::R::::::E:::::::KN::::::::::::::G:::::::::::::A:::::S::::::

consensus       DMLQRELLDIWAETGKTVLFVTHDVEEAVTLADRIVVMAANPGRVAEIVDIDVDRPRERT
#oth            11.12...11.32.2..1.....111........1..1122.111312.11.12...2.1
Hbo3003         :H:::::::::Q::E::I:::::EI::::::::::::LGS::DDSITT:::::E:::D::
hla1116         E::::::::V:GS::::::::::::A::::::::::::::E::::::L::V::P:::::G
HVO_1601        :::HG:::::::::D:::::::::::::::::::V::::::::::R:::SV:I:::::::
HQ2632A         E::HD:::S::TT:::::::::::::::::::::V::::PS::::N:::::::::::Q::

consensus       DPEFGEYVERIRELIGE---------
#oth            222.2221121.2..12221111111
Hbo3003         A:::VSLI:EV::::EQRGRSAEQSH
hla1116         ::A:::H:A:V:::::AGP:::::::
HVO_1601        ES::AA::::::G:::::::::::::
HQ2632A         :VT::::::Q::S:::::::::::::