4 genomes BUD2254 4 proteins a Hsa Halobacterium sp. NRC-1 b Hma Haloarcula marismortui f Hvo Haloferax volcanii g Hbo Halogeometricum borinquense h Hmu Halomicrobium mukohataei i Hut Halorhabdus utahensis j Hla Halorubrum lacusprofundi q Nph Natronomonas pharaonis x Hwa Haloquadratum walsbyi - - HVO_2501 Hbo2181 - - hla1658 - HQ2769A

Pairwise sequence scores
Consensus score	2471	HQ2769A	HVO_2501	Hbo2181	hla1658
1666	HQ2769A	2517	1252	1435	1210
1776	HVO_2501	1252	2529	1309	1346
1784	Hbo2181	1435	1309	2439	1370
1739	hla1658	1210	1346	1370	2567

341 symbols
consensus       MSDADSAIDRG-----------------VGPDDIQLN---VRGTSRRVDVGDVTLHVVEA
#oth            1233322333.111111111111111111312223231112222.23111.2.2..2.2.
HQ2769A         -MHI:AQ::V:::::::::::::::::::::S::G::NHNA:V::KL:::::::::C:L:
HVO_2501        -----M:KQS::::::::::::::::::LSW::VE:S::::EA::::I:A:E::::A:::
Hbo2181         ::SLG::VEG:::::::::::::::::::T:EVL:--:::I::E:QF:E::N:E::::T:
hla1658         ::::S:ETS::EEPAGARFLGVEALDET:P::E:PEE::::P:K::V::::::R::::::

consensus       GPEDGELVVLLHGFPEFWYAWHEYIRPLAAAGYRVVVPDQRGYNLSDRPDAVSAYHIDAL
#oth            ..2..2211.......1..2.112131.131....111.....11.11.31122.22.1.
HQ2769A         ::S::DV:L::::::::::E:::::L:::::::::::::::::HR:E::::I::::L:::
HVO_2501        ::::::::::::::::C::::AD:L:::SE::::::AL:::::::::::PG:EW:S::E:
Hbo2181         ::K:::P::::::::::::::::FLG:::DE::::I:::::::H:::K:E::D:::P:E:
hla1658         :::::K:L:::::::::::G:::T:VS::N::::::::::::::::EK:S:::D:R::::

consensus       ARDVVGLLDALDAETAHVVGHDWGAAVAWWVALHHPDRLRTLSAINVPHPTAFARALRRD
#oth            .3.12.22..213221121.....11.2..21..111.1121213.1....11322.222
HQ2769A         :T:IC:I:::IG:KKT:I:::::::F:S::::::::A::::::V:::::::::KQT:W:N
HVO_2501        :G::::VA:::GH:::::::::::G:::::T:::::::V:S:T:M:L::::VL::H::::
Hbo2181         :D::L:::::::LSD::L:::::::F:::::G::A::::::::VL::::::::RH::SN:
hla1658         :::::::I::Y:R:::A:A::::::::G::L::::A::VSEFV:V::::::V:E::::TS

consensus       PDQRLRSWYVLFFQLPKLPEALAQVGNWALLCRAMRRSSRPGTFSAADFDRYRAAWSRPG
#oth            13.2.1....11....12..11.32.21132323122.131...232.121..2..222.
HQ2769A         :K:V::::::G:::::RV:::::::::::SVTAM:Q::::D:::DST::E:::T::GLD:
HVO_2501        :G:Q::::::::::::::::LV:P::D::V:E:::TG:AL::::::::L::::::::V::
Hbo2181         WE:::K:::::::::::I:::::KM:EYRT::DL:::::Q::::NE::::C:::::::::
hla1658         W::::K:::::A:::::::::V:SA:::R:AV:GL:E::D:::::GE::R:::R::N:E:

consensus       AYEAMVNWYRAIVRARPRPATETVDVPTLVLWGAKDRFLTRSLARESVAYCENGHLVILD
#oth            .121.11....11.31.2.3212131..112..11.2..2221.32.232.211212311
HQ2769A         :::::I:::::V::SN:Q:VQTQIST::ML::::Q:T:::::::EK:AQ::T:SEV:MFE
HVO_2501        ::GS::D::::V::E::::RA:::::::::V::S:::::RPKM::::L:F::D:::KTFE
Hbo2181         ::RS::::::::A::N:::K::R:G:::::::::::A:::::::LQ::E::::S:::V::
hla1658         :F::::::::::::D::T::::::E:::::I::::::::STR::G:::DR:AD:R:L:::

consensus       DATHWIQHEEPVRVARALADHFD-A-------PDQPGHR--
#oth            3....13...122.122231.22212221111232222121
HQ2769A         Q:::::T:::QTQ:QNR:L:::NS:HKI::::TH:KR:-::
HVO_2501        E::::VH:::::A::::VVE:L:D:WRTPNNT::EA:::PV
Hbo2181         ::::::::::::::Q:E:T:::G:-:::::::MY::---::
hla1658         T::::VV::::H:::K:I:::A::-::::::::LP::A:E: